2023
Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements
Sherman B, Harris B, Turk-Browne N, Sinha R, Goldfarb E. Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements. Journal Of Neuroscience 2023, 43: 7198-7212. PMID: 37813570, PMCID: PMC10601369, DOI: 10.1523/jneurosci.0916-23.2023.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMemory enhancementEpisodic memoryAssociative memoryEpisodic memory encodingBrain regionsHigh-resolution functional magnetic resonance imagingHuman hippocampusHigh-resolution fMRIStress-related hormone cortisolHormone cortisolMemory benefitsEmotional memoryMemory encodingEmotional eventsEmotional associationsHippocampal representationsHippocampal signaturesFunctional neuroimagingHippocampal mechanismsStressful eventsFunctional connectivityHippocampal functionMemory formationSalient information
2020
1994-P: Task-Oriented Connectivity Analysis of Disease-Dependent Effects of Diet
WATT C, STANLEY T, LACADIE C, LAM K, SAVOYE M, SINHA R, CONSTABLE T, SEO D, HWANG J, BELFORT-DEAGUIAR R. 1994-P: Task-Oriented Connectivity Analysis of Disease-Dependent Effects of Diet. Diabetes 2020, 69 DOI: 10.2337/db20-1994-p.Peer-Reviewed Original ResearchMedial hippocampusFunctional MRIFunctional connectivityFood cue taskLow-calorie dietNational InstituteBrain functional connectivityLevel-dependent responsesModulation of emotionSignificant diet effectAnterior amygdalaInferior ponsObese subjectsKidney diseaseGlucose metabolismNeuronal controlMetabolic diseasesNeuronal adaptionBrain regionsBrain connectivityWeight lossDisease statesDiet effectsDietHippocampus
2019
How Spirituality May Mitigate Against Stress and Related Mental Disorders: a Review and Preliminary Neurobiological Evidence
McClintock C, Worhunsky P, Balodis I, Sinha R, Miller L, Potenza M. How Spirituality May Mitigate Against Stress and Related Mental Disorders: a Review and Preliminary Neurobiological Evidence. Current Behavioral Neuroscience Reports 2019, 6: 253-262. DOI: 10.1007/s40473-019-00195-0.Peer-Reviewed Original ResearchBrain mechanismsStress processingSelf-referential processingFunctional magnetic resonance imaging (fMRI) dataPotential brain mechanismsSpecific brain mechanismsImportant resilience factorMental disordersPreliminary fMRI dataStress-related psychopathologyMechanisms of psychopathologyDefault mode networkStress-related mental disordersCognitive processingNeurobiological evidenceNeural mechanismsNeural responsesNeuroscientific researchResilience factorsMagnetic resonance imaging dataNeural circuitryFMRI dataStress responsivityBrain regionsAcute stress
2018
Stress and Addiction
Sinha R. Stress and Addiction. 2018, 299-311. DOI: 10.4324/9781315689197-25.Peer-Reviewed Original ResearchExecutive control functionsNegative emotional statesChronic stressEarly life stressCortical brain regionsEmotional statesAddiction vulnerabilityStressful situationsMesolimbic dopamine pathwayLife stressAddiction severityBrain regionsType of adaptationDrug useDopamine pathwayAlters activityRelapse riskEmotionsIndividualsDistressControl functionsAddictionAbuseBehaviorStress
2016
Neural stress reactivity relates to smoking outcomes and differentiates between mindfulness and cognitive-behavioral treatments
Kober H, Brewer JA, Height KL, Sinha R. Neural stress reactivity relates to smoking outcomes and differentiates between mindfulness and cognitive-behavioral treatments. NeuroImage 2016, 151: 4-13. PMID: 27693614, PMCID: PMC5373945, DOI: 10.1016/j.neuroimage.2016.09.042.Peer-Reviewed Original ResearchConceptsCognitive-behavioral treatmentFunctional magnetic resonance imagingStress reactivityMindfulness-based treatmentsAmerican Lung Association's FreedomUnderstanding of stressPsychological mechanismsMindfulness trainingNegative affectConjunction analysisMid insulaCBT groupStress provocationSmoking outcomesBrain regionsCessation treatmentEfficacy of MTCurrent studyEntire sampleDrug useSmoking cessationImportant implicationsMagnetic resonance imagingMindfulnessInsula
2011
Circulating glucose levels modulate neural control of desire for high-calorie foods in humans
Page KA, Seo D, Belfort-DeAguiar R, Lacadie C, Dzuira J, Naik S, Amarnath S, Constable RT, Sherwin RS, Sinha R. Circulating glucose levels modulate neural control of desire for high-calorie foods in humans. Journal Of Clinical Investigation 2011, 121: 4161-4169. PMID: 21926468, PMCID: PMC3195474, DOI: 10.1172/jci57873.Peer-Reviewed Original ResearchConceptsHigh-calorie foodsGlucose levelsHyperinsulinemic euglycemic-hypoglycemic clampsBrain regionsFunctional MRIMedial prefrontal cortexMedial prefrontal cortex activationRisk of overeatingLevels of glucosePostprandial reductionPrefrontal cortex activationObese subjectsNonobese individualsMild hypoglycemiaWorldwide epidemicCortex activationPrefrontal cortexFood cuesFood motivationFood stimuliNeural controlObesityInhibitory controlBehavioral measuresVisual cues
2009
Decreased Activity in Brain Regions of Emotion Regulation Predicted Alcohol Cravings during Stress and Alcohol-cue Exposures in Individuals with Alcohol Dependence
Seo D, Lacadie C, Bergquist K, Sinha R. Decreased Activity in Brain Regions of Emotion Regulation Predicted Alcohol Cravings during Stress and Alcohol-cue Exposures in Individuals with Alcohol Dependence. NeuroImage 2009, 47: s138. DOI: 10.1016/s1053-8119(09)71362-x.Peer-Reviewed Original Research
2006
Imaging Response Inhibition in a Stop-Signal Task: Neural Correlates Independent of Signal Monitoring and Post-Response Processing
Li CS, Huang C, Constable RT, Sinha R. Imaging Response Inhibition in a Stop-Signal Task: Neural Correlates Independent of Signal Monitoring and Post-Response Processing. Journal Of Neuroscience 2006, 26: 186-192. PMID: 16399686, PMCID: PMC6674298, DOI: 10.1523/jneurosci.3741-05.2006.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeStop-signal taskResponse inhibitionPre-potent response tendenciesReaction timeShorter stop-signal reaction timesEfficient response inhibitionFunctional magnetic resonanceLonger stop-signal reaction timesGroups of subjectsHigher cortical functionsError monitoringNeural correlatesTask demandsHabitual responsesBrain activationNeural substrataResponse tendenciesGreater activationInhibitory controlAffective functionsMotor areaBrain regionsFrontal cortexCortical function