Association Between Targeted HER-2 Therapy and Breast Reconstruction Outcomes: A Propensity Score-Matched Analysis
Shammas R, Cho E, Glener A, Poveromo L, Mundy L, Greenup R, Blackwell K, Hollenbeck S. Association Between Targeted HER-2 Therapy and Breast Reconstruction Outcomes: A Propensity Score-Matched Analysis. Journal Of The American College Of Surgeons 2017, 225: 731-739.e1. PMID: 28985927, DOI: 10.1016/j.jamcollsurg.2017.08.023.Peer-Reviewed Original ResearchConceptsPostoperative wound breakdownBreast reconstructionReconstructive complicationsWound breakdownReconstructive operationsPropensity score-matched pairsMastectomy skin flap necrosisDuke University Medical CenterAdministration of trastuzumabPrimary study outcomeSkin flap necrosisLarger tumor sizePost-mastectomy reconstructionBreast reconstruction outcomesOccurrence of hematomaUniversity Medical CenterPertuzumab therapyChemotherapy regimenNeoadjuvant chemotherapyOperative interventionFlap thrombosisTrastuzumab therapySurgical outcomesTumor sizeFlap necrosisRole of axillary node dissection after mastectomy with positive sentinel nodes.
Park T, Thomas S, Greenup R, Hwang E. Role of axillary node dissection after mastectomy with positive sentinel nodes. Journal Of Clinical Oncology 2017, 35: 554-554. DOI: 10.1200/jco.2017.35.15_suppl.554.Peer-Reviewed Original ResearchAxillary lymph node dissectionPositive sentinel nodesAdjuvant radiationNode dissectionSentinel nodesTumor sizeRadiation treatmentComparable overall survivalLymph node dissectionMedian tumor sizeNational Cancer DatabaseStage IV diseaseAxillary node dissectionBreast conservation therapyHazard of deathAxillary lymphadenectomyPositive SLNZ11 trialCause mortalityEndocrine therapyNeoadjuvant chemotherapyPositive nodesNegative patientsOverall survivalSentinel lymph