Multifunctional Core–Shell Glyconanoparticles for Galectin-3-Targeted, Trigger-Responsive Combination Chemotherapy
Balakrishnan B, Subramanian S, Mallia MB, Repaka K, Kaur S, Chandan R, Bhardwaj P, Dash A, Banerjee R. Multifunctional Core–Shell Glyconanoparticles for Galectin-3-Targeted, Trigger-Responsive Combination Chemotherapy. Biomacromolecules 2020, 21: 2645-2660. PMID: 32484667, DOI: 10.1021/acs.biomac.0c00358.Peer-Reviewed Original ResearchMeSH KeywordsDoxorubicinDrug Delivery SystemsDrug Therapy, CombinationEndothelial CellsGalectin 3Hydrogen-Ion ConcentrationNanoparticlesTissue DistributionConceptsCore-shell nanoparticlesTarget specific drug releaseMultivalent ligand presentationCombination drug deliveryBoronate estersDrug releaseSchiff baseMDA-MB-231 cancer cellsCitrus pectinDrug deliveryNanoparticlesPlacebo nanoparticlesProof of conceptPeriodate oxidationLigand presentationGlyconanoparticlesVivo monitoringEnhanced internalizationTarget specificityGastric tractTriple-negative MDA-MB-231 breast cancer cellsBiodistribution studiesHomotypic cellular aggregationDoxorubicinShell