Ultrasound augments on-demand breast tumor radiosensitization and apoptosis through a tri-responsive combinatorial delivery theranostic platform
Bhardwaj P, Goda JS, Pai V, Chaudhari P, Mohanty B, Pai T, Vishwakarma K, Thorat R, Wadasadawala T, Banerjee R. Ultrasound augments on-demand breast tumor radiosensitization and apoptosis through a tri-responsive combinatorial delivery theranostic platform. Nanoscale 2021, 13: 17077-17092. PMID: 34622906, DOI: 10.1039/d1nr04211d.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisHumansMiceMice, Inbred NODMice, SCIDPositron Emission Tomography Computed TomographyPrecision MedicineTriple Negative Breast NeoplasmsTumor MicroenvironmentConceptsTriple-negative breast cancerBreast cancerAdvanced triple-negative breast cancerPathological response rateCombination of paclitaxelTumor microvessel densityNOD-SCID micePET-CT imagingDose-dependent systemic toxicityCell proliferation markersChemoradiotherapeutic efficacyClinical radiosensitizerNeoadjuvant chemotherapyNeoadjuvant chemoradiotherapyTNBC xenograftsAggressive tumorsCombinatorial regimenConcomitant useMouse survivalMicrovessel densityPathological responseClinical utilitySpatio-temporal deliveryResponse rateSolid tumors