Attenuation of rodent lung ischemia–reperfusion injury by sphingosine 1-phosphate
Moreno-Vinasco L, Jacobson J, Bonde P, Sammani S, Mirzapoiazova T, Vigneswaran W, Garcia J. Attenuation of rodent lung ischemia–reperfusion injury by sphingosine 1-phosphate. Journal Of Organ Dysfunction 2008, 4: 106-114. DOI: 10.1080/17471060701505289.Peer-Reviewed Original ResearchLung ischemia-reperfusion injuryIschemia-reperfusion injuryIR injuryBronchoalveolar lavage inflammatory cellsPronounced anti-inflammatory effectLung myeloperoxidase activityLung preservation strategiesLung preservation techniquesPulmonary artery ligationAnti-inflammatory effectsLung vascular permeabilityBAL neutrophilsAlveolar damageDonor lungsMyeloperoxidase activityTransplant failureArtery ligationBAL fluidLeukocyte infiltrationSubsequent reperfusionIL-1βIL-6Inflammatory cellsIL-2Rat model