2022
Novel pathways of intracellular membrane lipid transport and neurodegenerative diseases
De Camilli P. Novel pathways of intracellular membrane lipid transport and neurodegenerative diseases. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.0i152.ChaptersFamily proteinsLipid transportMembrane lipid transportMembrane contact sitesLipid binding modulesLipid transport proteinsLipid trafficRod-like proteinsBinding modulesHydrophobic grooveTransport proteinsContact sitesMembrane lipidsFunction mutationsLipid transferNovel pathwayNeurodevelopmental diseasesProteinVesicular carriersFamily resultsNeurodegenerative diseasesChorea-AcanthocytosisPotential roleNew mechanismMembrane
2021
Insights into VPS13 properties and function reveal a new mechanism of eukaryotic lipid transport
Leonzino M, Reinisch KM, De Camilli P. Insights into VPS13 properties and function reveal a new mechanism of eukaryotic lipid transport. Biochimica Et Biophysica Acta (BBA) - Molecular And Cell Biology Of Lipids 2021, 1866: 159003. PMID: 34216812, PMCID: PMC8325632, DOI: 10.1016/j.bbalip.2021.159003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutophagosomesAutophagy-Related ProteinsCryoelectron MicroscopyDisease Models, AnimalEukaryotic CellsHeredodegenerative Disorders, Nervous SystemHumansHydrophobic and Hydrophilic InteractionsLipid BilayersLipid MetabolismMitochondrial MembranesMutationProtein DomainsStructure-Activity RelationshipVesicular Transport ProteinsYeastsConceptsLipid transportMembrane contact sitesDomain protein familyOccurrence of proteinsVPS13 proteinsEukaryotic cellsNumerous proteinsProtein familyIntracellular membranesProtein bridgeHydrophobic grooveContact sitesMembrane growthLipid transferBilayer lipidsNovel mechanismVps13New mechanismProteinLipidsAtg2OrganellesAdjacent bilayersDiscoveryMechanism