2007
Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions
Corlett PR, Murray GK, Honey GD, Aitken MR, Shanks DR, Robbins TW, Bullmore ET, Dickinson A, Fletcher PC. Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions. Brain 2007, 130: 2387-2400. PMID: 17690132, PMCID: PMC3838942, DOI: 10.1093/brain/awm173.Peer-Reviewed Original ResearchConceptsDelusion formationDelusional beliefsPrediction error processingPrediction-error signallingPrediction error signalsAttentional allocationAssociative accountMaladaptive beliefsError processingAssociative learningNeurobiological theoriesBrain responsesCortex responsesIndividual's propensityBelief formationDelusionsBeliefsPrediction errorExtent of disruptionProcessingFMRILearningPsychosisExpectancyIndividuals
2005
Functional dysconnectivity in schizophrenia associated with attentional modulation of motor function
Honey G, Pomarol-Clotet E, Corlett P, Honey R, Mckenna P, Bullmore E, Fletcher P. Functional dysconnectivity in schizophrenia associated with attentional modulation of motor function. Brain 2005, 128: 2597-2611. PMID: 16183659, PMCID: PMC3838931, DOI: 10.1093/brain/awh632.Peer-Reviewed Original ResearchConceptsCognitive dysmetria hypothesisPatient groupAnterior cingulateFunctional MRIContinuous performance taskFunctional dysconnectivitySchizophrenia patientsPositive symptomsNegative symptomsMedial superior frontal gyrusThalamo-cortical circuitsDistinct symptom profilesSupplementary motor areaCases of schizophreniaSuperior frontal gyrusFunctional imaging studiesTask-related connectivityGroups of subjectsIllness onsetControl subjectsFunctional deficitsMotor functionHealthy volunteersMotor areaFundamental abnormality