2024
Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia
Suthaharan P, Thompson S, Rossi-Goldthorpe R, Rudebeck P, Walton M, Chakraborty S, Noonan M, Costa V, Murray E, Mathys C, Groman S, Mitchell A, Taylor J, Corlett P, Chang S. Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia. Cell Reports 2024, 43: 114355. PMID: 38870010, PMCID: PMC11231991, DOI: 10.1016/j.celrep.2024.114355.Peer-Reviewed Original ResearchOrbitofrontal cortexMediodorsal thalamusReward learning rateAssociated with paranoiaExcitotoxic lesionsBrain regionsUnoperated monkeysAction selectionAdaptive behaviorParanoiaBelief updatingMDmcMeaningful changeCortexThalamusBeliefsLearning rateRobust to variabilityCompare performanceRewardBehaviorBrainMonkeysAction policiesPerceptionImagination, Agency, and Predictive Processing
Corlett P. Imagination, Agency, and Predictive Processing. 2024, 60-78. DOI: 10.1093/oso/9780198872221.003.0004.Peer-Reviewed Original ResearchPredictive processing theoryTheories of delusionsPredictive coding theorySensory inputDelusion formationSource monitoringProcess theoryDelusionsMediated learningHallucinationsConscious experienceImaginative processesReality perceptionPrediction processNeurocomputer architectureBeliefsPerceptionDysfunction
2023
The association between evening social media use and delayed sleep may be causal: Suggestive evidence from 120 million Reddit timestamps
Meyerson W, Fineberg S, Andrade F, Corlett P, Gerstein M, Hoyle R. The association between evening social media use and delayed sleep may be causal: Suggestive evidence from 120 million Reddit timestamps. Sleep Medicine 2023, 107: 212-218. PMID: 37235891, DOI: 10.1016/j.sleep.2023.04.021.Peer-Reviewed Original ResearchConceptsSocial media useDelayed sleep onsetSelf-reported sleep patternsMedia useIndividual differencesDelayed sleepInsufficient sleepSleep onsetSleep patternsReddit usersSleepSocial media usageBedtimeSocial media usersAdditional supportOnset of sleepSocial mediaCausal effectMedia usageCausal relationshipPublic health officialsMedia usersPerceptionSuggestive evidenceReddit
2010
Toward a neurobiology of delusions
Corlett PR, Taylor JR, Wang X, Fletcher PC, Krystal JH. Toward a neurobiology of delusions. Progress In Neurobiology 2010, 92: 345-369. PMID: 20558235, PMCID: PMC3676875, DOI: 10.1016/j.pneurobio.2010.06.007.Peer-Reviewed Original ResearchConceptsFundamental brain mechanismsFronto-striatal circuitsTerms of cognitionPsychological processesBrain mechanismsComputational mechanismsCortical hierarchyPrediction errorSocial learningParietal cortexExternal worldBrain circuitsNeurobiological abnormalitiesNeurobiology of delusionsBrain functionHierarchical predictionBodily agencyDelusionsMemoryReinforcement learningPerceptionMental illnessTranslational understandingLearningCognition
2009
From drugs to deprivation: a Bayesian framework for understanding models of psychosis
Corlett PR, Frith CD, Fletcher PC. From drugs to deprivation: a Bayesian framework for understanding models of psychosis. Psychopharmacology 2009, 206: 515-530. PMID: 19475401, PMCID: PMC2755113, DOI: 10.1007/s00213-009-1561-0.Peer-Reviewed Original ResearchConceptsSymptoms of psychosisImportance of perceptionsProcessing of informationCognitive modelPrior expectanciesPerceptual AberrationModel of psychosisNeural circuitryInformation processingDifferent manipulationsPositive symptomsExperimental manipulationSerotonergic hallucinogensPerceptionPsychosisNew predictionsPsychotomimetic drugsUseful settingProcessingDistinctive effectsSymptomsInferenceNMDA receptor antagonistDistinct symptomsLearning