2024
Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia
Suthaharan P, Thompson S, Rossi-Goldthorpe R, Rudebeck P, Walton M, Chakraborty S, Noonan M, Costa V, Murray E, Mathys C, Groman S, Mitchell A, Taylor J, Corlett P, Chang S. Lesions to the mediodorsal thalamus, but not orbitofrontal cortex, enhance volatility beliefs linked to paranoia. Cell Reports 2024, 43: 114355. PMID: 38870010, PMCID: PMC11231991, DOI: 10.1016/j.celrep.2024.114355.Peer-Reviewed Original ResearchOrbitofrontal cortexMediodorsal thalamusReward learning rateAssociated with paranoiaExcitotoxic lesionsBrain regionsUnoperated monkeysAction selectionAdaptive behaviorParanoiaBelief updatingMDmcMeaningful changeCortexThalamusBeliefsLearning rateRobust to variabilityCompare performanceRewardBehaviorBrainMonkeysAction policiesPerception
2017
2.1 Transcranial Magnetic Stimulation for Voices That Are Distressing
Corlett P. 2.1 Transcranial Magnetic Stimulation for Voices That Are Distressing. Schizophrenia Bulletin 2017, 43: s1-s1. PMCID: PMC5475441, DOI: 10.1093/schbul/sbx021.002.Peer-Reviewed Original ResearchTranscranial magnetic stimulationFunctional magnetic resonance imagingWernicke's areaMagnetic stimulationDaily transcranial magnetic stimulationBilateral transcranial magnetic stimulationBrains of patientsDouble-cone coilMagnetic resonance imagingIntrinsic connectivity analysesAuditory verbal hallucinationsMechanisms of hallucinationsInsula cortexAuditory hallucinationsResonance imagingOrbitofrontal cortexNeural circuitryPatientsInsulaVerbal hallucinationsAberrant activityHallucinationsBrain activityEffective connectivityPrecise treatment