2024
Different learning aberrations relate to delusion-like beliefs with different contents
Rossi-Goldthorpe R, Silverstein S, Gold J, Schiffman J, Waltz J, Williams T, Powers A, Woods S, Zinbarg R, Mittal V, Ellman L, Strauss G, Walker E, Levin J, Castiello S, Kenney J, Corlett P. Different learning aberrations relate to delusion-like beliefs with different contents. Brain 2024, 147: 2854-2866. PMID: 38637303, PMCID: PMC11292907, DOI: 10.1093/brain/awae122.Peer-Reviewed Original ResearchProbabilistic reversal learningDelusion-like beliefsProbabilistic reversal learning taskBlocked cueControl cuesBelief convictionBlock taskClinical high-risk statusKamin blocking taskSymptom-specific effectsPrediction error accountLevels of paranoiaIntact learningAberrant learningKamin blockingParanoid individualsPersecutory delusionsCue presentationReversal learningPredicting psychosisCognitive tasksBehavioral resultsDecreased learningDelusionsParanoia
2006
Frontal Responses During Learning Predict Vulnerability to the Psychotogenic Effects of Ketamine: Linking Cognition, Brain Activity, and Psychosis
Corlett PR, Honey GD, Aitken MR, Dickinson A, Shanks DR, Absalom AR, Lee M, Pomarol-Clotet E, Murray GK, McKenna PJ, Robbins TW, Bullmore ET, Fletcher PC. Frontal Responses During Learning Predict Vulnerability to the Psychotogenic Effects of Ketamine: Linking Cognition, Brain Activity, and Psychosis. JAMA Psychiatry 2006, 63: 611-621. PMID: 16754834, DOI: 10.1001/archpsyc.63.6.611.Peer-Reviewed Original ResearchMeSH KeywordsAdultAssociation LearningBrief Psychiatric Rating ScaleCognition DisordersDelusionsDisease SusceptibilityDose-Response Relationship, DrugFemaleFrontal LobeHumansKetamineMagnetic Resonance ImagingMaleModels, TheoreticalPerceptual DisordersPlacebosProbabilityPsychiatric Status Rating ScalesPsychoses, Substance-InducedPsychotic DisordersConceptsDelusion formationPerceptual AberrationBrain activityError-dependent learningPharmacological functional magnetic resonanceAssociative learning taskFunctional magnetic resonance imagingAssociative learning processesDelusion-like beliefsFrontal cortical functionFunctional magnetic resonanceFull Scale IQUnderstanding of psychosisRight frontal cortexRight-handed volunteersNeurobiological accountsCognitive processesClinical Neuroscience InstituteFrontal activationAssociative learningFrontal responseBrain activationStructured Clinical InterviewLearning taskPsychotogenic effects