2024
Absence of Anti-Babesia microti antibody in commercial intravenous immunoglobulin (IVIG)
Kostka J, Maharjan A, Kumar S, Hackenyos D, Krause P, Dieckhaus K. Absence of Anti-Babesia microti antibody in commercial intravenous immunoglobulin (IVIG). PLOS Neglected Tropical Diseases 2024, 18: e0012035. PMID: 38484010, PMCID: PMC10965045, DOI: 10.1371/journal.pntd.0012035.Peer-Reviewed Original ResearchConceptsIntravenous immunoglobulinB. microti antibodiesBabesiosis patientsSpectrum of disease severityCommercial intravenous immunoglobulinEffective treatment strategiesSevere organ damageHost antibody responseImmunocompromised patientsAdjunctive therapyOrgan damageTreatment strategiesAcute andClinical trialsMicroti antibodiesAsymptomatic infectionAntibody responseTherapeutic benefitTherapeutic effectPatientsDisease severityAntibodiesImmunofluorescence assayProtozoan infectionsCommercial samples
2023
Immune Control in Repeated Babesia microti Infection in a Patient With B-Cell Deficiency
Little J, Oakley M, Thorner A, Johnston D, Majam V, Liakos A, Novack L, Zheng H, Meredith S, Chou C, Newton B, Soiffer R, Krause P, Baden L, Kumar S. Immune Control in Repeated Babesia microti Infection in a Patient With B-Cell Deficiency. Open Forum Infectious Diseases 2023, 11: ofad568. PMID: 38213635, PMCID: PMC10783156, DOI: 10.1093/ofid/ofad568.Peer-Reviewed Original ResearchB-cell deficiencyParasite burdenHuman babesiosisBabesia microti infectionHigher antibody levelsMild clinical symptomsSevere B cell deficiencyB cell populationsT memory stem cellsMemory stem cellsPeak parasite burdenClinical immunityImmune controlImmunologic findingsNK cellsAntibody levelsClinical symptomsMicroti infectionB cellsPatientsSpecific antibodiesStem cellsBabesiosisImmunologyDeficiencyNeurologic Complications of Babesiosis, United States, 2011–2021 - Volume 29, Number 6—June 2023 - Emerging Infectious Diseases journal - CDC
Locke S, O’Bryan J, Zubair A, Rethana M, Moffarah A, Krause P, Farhadian S. Neurologic Complications of Babesiosis, United States, 2011–2021 - Volume 29, Number 6—June 2023 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2023, 29: 1127-1135. PMID: 37209667, PMCID: PMC10202888, DOI: 10.3201/eid2906.221890.Peer-Reviewed Original ResearchConceptsNeurologic complicationsNeurologic symptomsRisk factorsYale-New Haven HospitalInfectious Diseases journal - CDCHigh-grade parasitemiaNeurologic risk factorsRange of symptomsAdult patientsRenal failureDiabetes mellitusFrequent symptomsHospital admissionImpaired consciousnessMedical recordsEndemic areasParasitic infectionsPatientsSymptomsIntraerythrocytic protozoaComplicationsBabesiosisNew HavenDeliriumMellitus
2022
Borrelia miyamotoi Meningoencephalitis in an Immunocompetent Patient
Gandhi S, Narasimhan S, Workineh A, Mamula M, Yoon J, Krause PJ, Farhadian SF. Borrelia miyamotoi Meningoencephalitis in an Immunocompetent Patient. Open Forum Infectious Diseases 2022, 9: ofac295. PMID: 35873293, PMCID: PMC9301576, DOI: 10.1093/ofid/ofac295.Peer-Reviewed Original ResearchEpidemiology of Hospitalized Patients with Babesiosis, United States, 2010–2016 - Volume 28, Number 2—February 2022 - Emerging Infectious Diseases journal - CDC
Bloch EM, Day JR, Krause PJ, Kjemtrup A, O’Brien S, Tobian AAR, Goel R. Epidemiology of Hospitalized Patients with Babesiosis, United States, 2010–2016 - Volume 28, Number 2—February 2022 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2022, 28: 354-362. PMID: 35076004, PMCID: PMC8798708, DOI: 10.3201/eid2802.210213.Peer-Reviewed Original ResearchConceptsNational Inpatient Sample databaseInfectious Diseases journal - CDCAnalysis of hospitalizationsHospitalized patientsAdvanced ageMortality rateHospitalizationSample databaseObservation periodEpidemiologyHigher severityPatientsBabesiosisDiagnosisUnited StatesReporting dataBabesiaAdmissionIllnessIncidenceDiseaseSeverity
2018
BmGPAC, an Antigen Capture Assay for Detection of Active Babesia microti Infection
Thekkiniath J, Mootien S, Lawres L, Perrin BA, Gewirtz M, Krause PJ, Williams S, Doggett J, Ledizet M, Mamoun C. BmGPAC, an Antigen Capture Assay for Detection of Active Babesia microti Infection. Journal Of Clinical Microbiology 2018, 56: 10.1128/jcm.00067-18. PMID: 30093394, PMCID: PMC6156295, DOI: 10.1128/jcm.00067-18.Peer-Reviewed Original ResearchConceptsHuman babesiosisBabesia microti infectionCapture enzyme-linked immunosorbent assayAntigen capture enzyme-linked immunosorbent assayAntigen capture assayEnzyme-linked immunosorbent assayZoonotic infectious diseaseAcute infectionBlood transfusionAsymptomatic infectionMicroti infectionReal-time PCRBlood supplyAnimal reservoir hostsDonor bloodEpidemiological surveyHuman patientsImmune systemSerological assaysImmunodominant antigensInfectionInfectious diseasesIntraerythrocytic protozoan parasitePatientsImmunosorbent assayHuman Babesiosis Caused by a Babesia crassa–Like Pathogen: A Case Series
Jia N, Zheng YC, Jiang JF, Jiang RR, Jiang BG, Wei R, Liu HB, Huo QB, Sun Y, Chu YL, Fan H, Chang QC, Yao NN, Zhang WH, Wang H, Guo DH, Fu X, Wang YW, Krause PJ, Song JL, Cao WC. Human Babesiosis Caused by a Babesia crassa–Like Pathogen: A Case Series. Clinical Infectious Diseases 2018, 67: 1110-1119. PMID: 29538646, DOI: 10.1093/cid/ciy212.Peer-Reviewed Original ResearchConceptsPolymerase chain reactionAsymptomatic infectionTick biteHuman babesiosisInfection 9 monthsRecent tick biteViral-like illnessCommon clinical manifestationsHaemaphysalis concinna ticksCase seriesInitial diagnosisClinical manifestationsOvarian tumorsModerate symptomsUS CentersBlood supplySevere diseaseHealthy residentsHealth problemsDisease controlInfectionChain reactionGenetic sequencingPatientsFurther investigation
2017
Case report of the patient source of the Babesia microti R1 reference strain and implications for travelers
Stahl P, Poinsignon Y, Pouedras P, Ciubotaru V, Berry L, Emu B, Krause PJ, Mamoun C, Cornillot E. Case report of the patient source of the Babesia microti R1 reference strain and implications for travelers. Journal Of Travel Medicine 2017, 25: tax073. PMID: 29394381, PMCID: PMC6927858, DOI: 10.1093/jtm/tax073.Peer-Reviewed Original ResearchConceptsIndirect immunofluorescence antibody testingBabesiosis casesB. microti antibodiesB. microtiTreatment of babesiosisImmunofluorescence antibody testingB. microti infectionNon-endemic areasDiagnosis of babesiosisMicroti antibodiesFebrile illnessImmunocompetent patientsRed blood cellsAntibody testingB. microti DNAPhysical examinationCase reportMedical historyMicroti infectionTick biteClinical informationEndemic areasPatient sourcePatientsBlood smears
2015
Apheresis for babesiosis: Therapeutic parasite reduction or removal of harmful toxins or both?
Saifee NH, Krause PJ, Wu Y. Apheresis for babesiosis: Therapeutic parasite reduction or removal of harmful toxins or both? Journal Of Clinical Apheresis 2015, 31: 454-458. PMID: 26481763, DOI: 10.1002/jca.21429.Peer-Reviewed Original ResearchConceptsExchange transfusionHigh-risk populationLife-threatening illnessApparent therapeutic benefitBlood transfusionModerate diseaseClinical presentationAsymptomatic infectionSevere babesiosisSevere diseaseRisk populationsTherapeutic benefitTransfusionMortality rateIntraerythrocytic protozoan parasiteBabesia infectionDiseaseIxodes ticksProtozoan parasiteBabesiosisInfectionGenus BabesiaMost casesPatientsClindamycinBabesiosis
Vannier EG, Diuk-Wasser MA, Mamoun C, Krause PJ. Babesiosis. Infectious Disease Clinics Of North America 2015, 29: 357-370. PMID: 25999229, PMCID: PMC4458703, DOI: 10.1016/j.idc.2015.02.008.Peer-Reviewed Original Research
2012
Preventing transfusion‐transmitted babesiosis: preliminary experience of the first laboratory‐based blood donor screening program
Young C, Chawla A, Berardi V, Padbury J, Skowron G, Krause PJ, Group T. Preventing transfusion‐transmitted babesiosis: preliminary experience of the first laboratory‐based blood donor screening program. Transfusion 2012, 52: 1523-1529. PMID: 22452654, DOI: 10.1111/j.1537-2995.2012.03612.x.Peer-Reviewed Original ResearchConceptsTransfusion-transmitted babesiosisCases of TTBPolymerase chain reactionBlood donorsThalassemia patientsCommon transfusion-transmitted infectionSickle cellsIndeterminate PCR resultsPositive IFA resultsTransfusion-transmitted infectionsInvestigational new drug applicationReal-time polymerase chain reactionUnscreened bloodDonor screeningPatientsIFA resultsDrug AdministrationNew drug applicationsPreliminary experienceIndirect immunofluorescenceBabesia microtiStudy designDrug applicationChain reactionPCR results
2011
Long-Term Lyme Disease Antibiotic Therapy Beliefs Among New England Residents
Macauda MM, Erickson P, Miller J, Mann P, Closter L, Krause PJ. Long-Term Lyme Disease Antibiotic Therapy Beliefs Among New England Residents. Vector-Borne And Zoonotic Diseases 2011, 11: 857-862. PMID: 21417921, DOI: 10.1089/vbz.2010.0116.Peer-Reviewed Original ResearchConceptsLyme diseasePersistent symptomsAntibiotic treatmentEffective doctor-patient communicationAntibiotic therapy regimensInfectious Diseases SocietyLong-term treatmentBorrelia burgdorferi infectionDoctor-patient communicationFederal health agenciesDiseases SocietyAppropriate therapyTherapy regimensAntimicrobial therapyBurgdorferi infectionHealthcare workersMost physiciansStandard diagnosisDisease controlDiseasePatientsHealth agenciesSymptomsPhysiciansMedical societies
2010
Emergence of Resistance to Azithromycin-Atovaquone in Immunocompromised Patients with Babesia microti Infection
Wormser GP, Prasad A, Neuhaus E, Joshi S, Nowakowski J, Nelson J, Mittleman A, Aguero-Rosenfeld M, Topal J, Krause PJ. Emergence of Resistance to Azithromycin-Atovaquone in Immunocompromised Patients with Babesia microti Infection. Clinical Infectious Diseases 2010, 50: 381-386. PMID: 20047477, DOI: 10.1086/649859.Peer-Reviewed Original ResearchConceptsDrug regimenB. microtiLevel of immunosuppressionBabesia microti infectionTreatment of babesiosisDrug-resistant strainsEmergence of resistanceActive babesiosisMicrobiologic relapseLaboratory abnormalitiesDrug regimensImmunocompromised patientsOptimal therapyTreatment failureDrug therapyMicroti infectionPatientsClinical case historiesDrug resistanceBabesia microtiInfectionRegimenMicrotiEventual developmentBabesiosis
2007
Serum Reactivity against Borrelia burgdorferi OspA in Patients with Rheumatoid Arthritis▿
Hsieh YF, Liu HW, Hsu TC, Wei J, Shih CM, Krause PJ, Tsay GJ. Serum Reactivity against Borrelia burgdorferi OspA in Patients with Rheumatoid Arthritis▿. MSphere 2007, 14: 1437-1441. PMID: 17881508, PMCID: PMC2168181, DOI: 10.1128/cvi.00151-07.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntibodies, BacterialAntigens, BacterialAntigens, SurfaceArthritis, RheumatoidAutoimmune DiseasesBacterial Outer Membrane ProteinsBacterial VaccinesBlotting, WesternBorrelia burgdorferiEnzyme-Linked Immunosorbent AssayFemaleHumansLipoproteinsLyme DiseaseMaleMiddle AgedRecombinant Fusion ProteinsConceptsRheumatoid arthritis patientsRheumatoid arthritisOspA antigenArthritis patientsAutoimmune diseasesSerum reactivityLyme diseaseDisease Activity ScoreCommon clinical featuresLyme disease patientsSurface protein AArthritis correlatesSynovial histologyOuter surface protein ALyme arthritisActivity scoreClinical featuresDisease patientsSerum concentrationsSimilar pathogenesisHealthy subjectsPatientsArthritisDisease severityDisease
2006
The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America
Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC, Klempner MS, Krause PJ, Bakken JS, Strle F, Stanek G, Bockenstedt L, Fish D, Dumler JS, Nadelman RB. The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America. Clinical Infectious Diseases 2006, 43: 1089-1134. PMID: 17029130, DOI: 10.1086/508667.Peer-Reviewed Original ResearchConceptsInfectious Diseases SocietyHuman granulocytic anaplasmosisDiseases SocietyLyme diseasePost-Lyme disease syndromeGranulocytic anaplasmosisPrevious treatment guidelinesManagement of patientsClinical practice guidelinesEvidence-based guidelinesHealth care providersTickborne infectionTreatment guidelinesClinical manifestationsAntimicrobial therapyClinical assessmentPractice guidelinesCare providersDisease syndromeExpert panelDiseasePreventionPatientsTherapyInfectionAbsence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patient
Clark IA, Budd AC, Hsue G, Haymore BR, Joyce AJ, Thorner R, Krause PJ. Absence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patient. Malaria Journal 2006, 5: 69. PMID: 16887045, PMCID: PMC1552079, DOI: 10.1186/1475-2875-5-69.Peer-Reviewed Original ResearchConceptsMulti-organ failureParasitized erythrocytesSevere multi-organ failureBabesia microti infectionChronic lymphocytic leukemiaCases of babesiosisFalciparum malariaSplenectomized patientsSimilar pathogenesisVascular occlusionMicroti infectionErythrocyte sequestrationLymphocytic leukemiaProtozoal infectionsVascular locationColon cancerHuman patientsResultsNo evidenceVascular lumenHuman casesB. microtiTissue sectionsPatientsPathogenesisInfection
2003
Coevolution of Markers of Innate and Adaptive Immunity in Skin and Peripheral Blood of Patients with Erythema Migrans
Salazar J, Pope C, Sellati T, Feder H, Kiely T, Dardick K, Buckman R, Moore M, Caimano M, Pope J, Krause P, Radolf J. Coevolution of Markers of Innate and Adaptive Immunity in Skin and Peripheral Blood of Patients with Erythema Migrans. The Journal Of Immunology 2003, 171: 4934-4934. DOI: 10.4049/jimmunol.171.9.4934-a.Peer-Reviewed Original Research
2002
Disease-Specific Diagnosis of Coinfecting Tickborne Zoonoses: Babesiosis, Human Granulocytic Ehrlichiosis, and Lyme Disease
Krause PJ, McKay K, Thompson CA, Sikand VK, Lentz R, Lepore T, Closter L, Christianson D, Telford SR, Persing D, Radolf JD, Spielman A, Group A. Disease-Specific Diagnosis of Coinfecting Tickborne Zoonoses: Babesiosis, Human Granulocytic Ehrlichiosis, and Lyme Disease. Clinical Infectious Diseases 2002, 34: 1184-1191. PMID: 11941544, DOI: 10.1086/339813.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisLyme diseaseImmunoglobulin M antibody testGranulocytic ehrlichiosisPolymerase chain reaction testingShort-term complicationsComplete blood countDisease-specific diagnosisFlulike illnessThin blood smearsLaboratory manifestationsAcute manifestationsBlood countBlood samplesAntibody testReaction testingBlood smearsTickborne zoonosesDiseaseHuman babesiosisLaboratory test resultsPatientsStructured questionnaireSymptomsBabesiosis
2001
HIV in primary care: an educational initiative for child health providers
Stille C, Berrien V, Krause P. HIV in primary care: an educational initiative for child health providers. Child Care Health And Development 2001, 7: 37-42. DOI: 10.1046/j.1467-0658.2001.00102.x.Peer-Reviewed Original ResearchChild health providersCare of childrenHIV infectionHealth providersGrand rounds lecturesPrimary care centersUrban children's hospitalCo-ordinated careInfectious disease subspecialistsHealth care needsHIV diseaseInfected childrenChildren's HospitalPrimary careCare centerAnticipatory guidanceDevelopmental monitoringCare needsClinical casesInfectionHealth issuesCareFurther sessionsComplex needsPatients
1999
Southern Extension of the Range of Human Babesiosis in the Eastern United States
Eskow E, Krause P, Spielman A, Freeman K, Aslanzadeh J. Southern Extension of the Range of Human Babesiosis in the Eastern United States. Journal Of Clinical Microbiology 1999, 37: 2051-2052. PMID: 10325378, PMCID: PMC85028, DOI: 10.1128/jcm.37.6.2051-2052.1999.Peer-Reviewed Original ResearchConceptsMicroti infectionBlood samplesB. microti antibodiesSerial blood samplesBabesia microti infectionB. microti infectionCollected blood samplesMicroti antibodiesAcute babesiosisImmunofluorescent antibodyHuman B. microti infectionBabesial antigensHuman babesiosisB. microtiInfectionBabesiosisAntibodiesPCR techniqueUnited StatesLocal acquisitionResidentsPatientsSymptomsAntigenBlood