2021
Tick hypersensitivity and human tick‐borne diseases
Ng YQ, Gupte TP, Krause PJ. Tick hypersensitivity and human tick‐borne diseases. Parasite Immunology 2021, 43: e12819. PMID: 33428244, DOI: 10.1111/pim.12819.Peer-Reviewed Original ResearchConceptsHypersensitivity reactionsImmune responseBlood mealTick-borne diseasesGeneralized hypersensitivity reactionHuman tick-borne diseasesHost immune responseLocal hypersensitivity reactionsLaboratory animal modelsItch responseCausative pathogenTick exposureSuch vaccinesTick salivary proteinsAnimal modelsAnti-tick vaccinesMost vector-borne diseasesTick salivaHuman investigationsDiseaseTick attachmentFuture preventionBlood coagulationHypersensitivity studiesVaccine
2019
Immunotherapy for Infectious Diseases, Cancer, and Autoimmunity
Krause P, Kavathas P, Ruddle N. Immunotherapy for Infectious Diseases, Cancer, and Autoimmunity. 2019, 265-276. DOI: 10.1007/978-3-030-25553-4_16.ChaptersSubset of patientsMonoclonal antibodiesSide effectsAutoimmune side effectsRespiratory syncytial virusMinimal side effectsInitial unresponsivenessCheckpoint inhibitorsAdverse eventsField of immunologyCheckpoint inhibitionTreatment failureCytokine inhibitorsSyncytial virusAutoimmune diseasesCancer immunotherapyInhibitory receptorsLate toleranceLung cancerImmune cellsPassive transferImmune regulationImmune responseImmunotherapyLatent infectionAdaptive Immunity: Effector Functions, Regulation, and Vaccination
Kavathas P, Krause P, Ruddle N. Adaptive Immunity: Effector Functions, Regulation, and Vaccination. 2019, 75-95. DOI: 10.1007/978-3-030-25553-4_5.ChaptersAntigen-presenting cellsT cellsB cellsImmune responseInnate cellsEffector cellsInnate antigen-presenting cellsCD4 T helper cellsEffector T cellsB memory cellsT helper cellsSecondary lymphoid organsNaive T cellsBalanced immune responsePathogen-infected host cellsCD4 subsetCytokine milieuHelper cellsLymphoid organsEffector TPlasma cellsEffector functionsAdaptive immuneTypes of pathogensMacrophage responseDisorders of the Immune System
Kavathas P, Krause P, Ruddle N. Disorders of the Immune System. 2019, 97-107. DOI: 10.1007/978-3-030-25553-4_6.ChaptersImmune systemImmune dysregulationHypersensitivity reactionsRegulation of autoimmunityMajor health problemHuman immune systemNumber of PIDsAllergic reactionsClinical impactAutoinflammatory diseasesForeign antigensImmune responseImmunodeficiency diseaseImmune functionHealth problemsNongenetic causesAutoimmunityHarmful responsesInborn errorsDiseaseType of disorderGenetic defectsImmunodeficiencyInfectionPredominant featureIntroduction to Immunology, Epidemiology, and Immunoepidemiology
Niccolai L, Ruddle N, Krause P. Introduction to Immunology, Epidemiology, and Immunoepidemiology. 2019, 3-17. DOI: 10.1007/978-3-030-25553-4_1.ChaptersIndividual multicellular organismsImmune responseMulticellular organismsRelevant health problemHealth-related eventsInflammatory diseasesSelect populationCombination of cellsHealth problemsEpidemiologic toolImmunoepidemiologyMicrobial infectionsEpidemiologyGenetic polymorphismsImmunologyEnvironmental factorsPopulationAutoimmunityMalignancyOrganismsInfectionDiversityDiseaseStudyAdaptive Immunity: Antigen Recognition by T and B Lymphocytes
Kavathas P, Krause P, Ruddle N. Adaptive Immunity: Antigen Recognition by T and B Lymphocytes. 2019, 55-74. DOI: 10.1007/978-3-030-25553-4_4.ChaptersB cell receptorCell receptorMajor histocompatibility complexB lymphocytesKiller T cellsEffective immune responseVariety of antigensT cell receptors (TCRs) bindCentral toleranceT cellsImmune responseHLA proteinsAntigen recognitionHistocompatibility complexIntracellular pathogensCell surfaceReceptorsHLALymphocytesCorresponding antibodiesHost cellsAntibodiesIsotypesMHC systemDefense mechanisms
2006
Confirmation of Tick Bite by Detection of Antibody to Ixodes Calreticulin Salivary Protein▿
Alarcon-Chaidez F, Ryan R, Wikel S, Dardick K, Lawler C, Foppa IM, Tomas P, Cushman A, Hsieh A, Spielman A, Bouchard KR, Dias F, Aslanzadeh J, Krause PJ. Confirmation of Tick Bite by Detection of Antibody to Ixodes Calreticulin Salivary Protein▿. MSphere 2006, 13: 1217-1222. PMID: 16928887, PMCID: PMC1656538, DOI: 10.1128/cvi.00201-06.Peer-Reviewed Original ResearchConceptsEnzyme-linked immunosorbent assayImmune responseTick exposureBALB/c miceC3H/HeNTick-borne infectionsHuman granulocytic anaplasmosisDetection of antibodiesLaboratory markersAntibody responseC miceTick biteSalivary proteinsObjective evidenceLyme diseaseImmunosorbent assayGranulocytic anaplasmosisHuman babesiosisSalivary glandsIxodes ticksAntibodiesBlood mealSame assayMiceSerum
2000
Serological Expression Cloning of Novel Immunoreactive Antigens of Babesia microti
Lodes M, Houghton R, Bruinsma E, Mohamath R, Reynolds L, Benson D, Krause P, Reed S, Persing D. Serological Expression Cloning of Novel Immunoreactive Antigens of Babesia microti. Infection And Immunity 2000, 68: 2783-2790. PMID: 10768973, PMCID: PMC97488, DOI: 10.1128/iai.68.5.2783-2790.2000.Peer-Reviewed Original ResearchConceptsRelated antigensBabesia microtiSerological expression cloningB. microtiHumoral immune responseB. microti infectionClass of antigensSporozoite surface antigenPatient serum poolsWestern blot analysisBlood transfusionMicroti infectionImmune responseSurface antigenImmunodominant antigensAntigenHuman babesiosisMolecular testsGenomic expression libraryPlasmodium spCausative agentSerum poolsImmunoreactive antigensBlot analysisMicroti