2017
Negative Multiparametric Magnetic Resonance Imaging of the Prostate Predicts Absence of Clinically Significant Prostate Cancer on 12-Core Template Prostate Biopsy
Lu AJ, Syed JS, Nguyen KA, Nawaf CB, Rosoff J, Spektor M, Levi A, Humphrey PA, Weinreb JC, Schulam PG, Sprenkle PC. Negative Multiparametric Magnetic Resonance Imaging of the Prostate Predicts Absence of Clinically Significant Prostate Cancer on 12-Core Template Prostate Biopsy. Urology 2017, 105: 118-122. PMID: 28322902, DOI: 10.1016/j.urology.2017.01.048.Peer-Reviewed Original ResearchConceptsMultiparametric magnetic resonance imagingSignificant prostate cancerProstate cancerNegative predictive valueMagnetic resonance imagingSystematic TRUSNegative mpMRIProstate biopsyNegative multiparametric magnetic resonance imagingPredictive valueResonance imagingClinically Significant Prostate CancerDynamic contrast enhancement sequencesTemplate mapping biopsyPrior negative biopsySystematic prostate biopsyOverall cancer detectionProstate-specific antigenTemplate prostate biopsyProstate cancer detectionDiffusion-weighted imagingCancer detectionBiopsy naïveMapping biopsyProstate volume
2008
Prognostic value of various morphometric measurements of tumour extent in prostate needle core tissue
Brimo F, Vollmer R, Corcos J, Kotar K, Bégin L, Humphrey P, Bismar T. Prognostic value of various morphometric measurements of tumour extent in prostate needle core tissue. Histopathology 2008, 53: 177-183. PMID: 18752501, DOI: 10.1111/j.1365-2559.2008.03087.x.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiopsy, NeedleHumansMaleMiddle AgedPredictive Value of TestsPrognosisProstatectomyProstate-Specific AntigenProstatic NeoplasmsConceptsPathological stageTumor lengthPrognostic valueTumor extentFinal pathological stageHigher stage diseaseNeedle biopsy specimenCancer patient outcomesPrognostic significanceBiochemical recurrenceBiopsy specimenRadical prostatectomyPatient outcomesBiopsy reportingFailure statusCancer lengthPositive coresPathological outcomesLarger studyMorphometric measurementsDiscontinuous fociCancerCore tissuePatientsOutcomes
2001
The Relative Importance of Anatomic and PSA Factors to Outcomes After Radical Prostatectomy for Prostate Cancer
Vollmer R, Humphrey P. The Relative Importance of Anatomic and PSA Factors to Outcomes After Radical Prostatectomy for Prostate Cancer. American Journal Of Clinical Pathology 2001, 116: 864-870. PMID: 11764075, DOI: 10.1309/7mq7-mwar-4w8a-r75f.Peer-Reviewed Original ResearchConceptsElevated PSA levelsEarly deathPSA levelsRadical prostatectomyProstate cancerPathology observationsGleason grade 5Overall good prognosisTime of prostatectomyPostoperative levelsPSA failureStudy patientsBetter prognosisProgressive tumorsPrognostic categoriesPercentage carcinomaProstatectomySubsequent outcomesLower hazardDeathSurgeryHigher hazardCancerMenPSALatent Prostate Carcinoma in a Screened Population
Kibel A, Humphrey P. Latent Prostate Carcinoma in a Screened Population. European Urology 2001, 39: 35-36. PMID: 11340287, DOI: 10.1159/000052583.Peer-Reviewed Original ResearchBiopsy, NeedleHumansMaleMass ScreeningNeoplasm StagingPreoperative CareProstate-Specific AntigenProstatic NeoplasmsSCATTER FACTOR-HEPATOCYTE GROWTH FACTOR ELEVATION IN THE SERUM OF PATIENTS WITH PROSTATE CANCER
NAUGHTON M, PICUS J, ZHU X, CATALONA W, VOLLMER R, HUMPHREY P. SCATTER FACTOR-HEPATOCYTE GROWTH FACTOR ELEVATION IN THE SERUM OF PATIENTS WITH PROSTATE CANCER. Journal Of Urology 2001, 165: 1325-1328. PMID: 11257710, DOI: 10.1016/s0022-5347(01)69893-8.Peer-Reviewed Original ResearchConceptsMetastatic prostate cancerProstate cancerMetastatic diseaseHepatocyte growth factorPatient ageSerum levelsNegative sextant prostate biopsiesProstate-specific antigen levelHuman prostate cancer cell linesAvailable enzyme-linked immunosorbentSextant prostate biopsySpecific antigen levelsNegative sextant biopsiesProstate cancer cell linesSera of patientsImportant serum markerLogistic regression analysisEnzyme-linked immunosorbentCancer cell linesLocalized cancerRadiographic evidenceSerum markersAntigen levelsSextant biopsyProstate biopsy
1998
Predicting the pathology results of radical prostatectomy from preoperative information
Vollmer R, Keetch D, Humphrey P. Predicting the pathology results of radical prostatectomy from preoperative information. Cancer 1998, 83: 1567-1580. PMID: 9781951, DOI: 10.1002/(sici)1097-0142(19981015)83:8<1567::aid-cncr12>3.0.co;2-e.Peer-Reviewed Original ResearchConceptsRadical prostatectomyPreoperative informationNeedle biopsyTumor volumeStatistical methodsWashington University Medical CenterAdvanced tumor stageProstate-specific antigenUniversity Medical CenterPreoperative variablesSerum PSATumor stagePathology resultsPathology outcomesMedical CenterProstate carcinomaSpecific antigenProstatectomyLogistic regressionBinary outcomesMultivariate modelProbabilityOutcomesBiopsyObserved probabilityTHE EFFECT OF PROSTATE VOLUME, AGE, TOTAL PROSTATE SPECIFIC ANTIGEN LEVEL AND ACUTE INFLAMMATION ON THE PERCENTAGE OF FREE SERUM PROSTATE SPECIFIC ANTIGEN LEVELS IN MEN WITHOUT CLINICALLY DETECTABLE PROSTATE CANCER
ORNSTEIN D, SMITH D, HUMPHREY P, CATALONA W. THE EFFECT OF PROSTATE VOLUME, AGE, TOTAL PROSTATE SPECIFIC ANTIGEN LEVEL AND ACUTE INFLAMMATION ON THE PERCENTAGE OF FREE SERUM PROSTATE SPECIFIC ANTIGEN LEVELS IN MEN WITHOUT CLINICALLY DETECTABLE PROSTATE CANCER. Journal Of Urology 1998, 159: 1234-1237. PMID: 9507843, DOI: 10.1016/s0022-5347(01)63570-5.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedHumansMaleMiddle AgedProstate-Specific AntigenProstatic NeoplasmsProstatitisConceptsProstate-specific antigen levelTotal PSA levelsSpecific antigen levelsDetectable prostate cancerSerum prostate-specific antigen levelFree PSA levelsPercent free PSAPSA levelsProstate volumeAcute inflammationAntigen levelsProstate cancerFree PSAFree Serum Prostate Specific Antigen LevelsTotal serum prostate-specific antigen (PSA) levelsTotal prostate-specific antigen levelsFree serum PSA levelsMean percent free PSAPercent free PSA levelsProstate cancer screening programsFree serum PSASerum PSA levelsLarge prostate glandsCancer screening programsInfluence of agePercentage of Free Serum Prostate-Specific Antigen as a Predictor of Pathologic Features of Prostate Cancer in a Screening Population fn1fn1This study was supported in part by a grant from Hybritech Incorporated, San Diego, California.
Arcangeli C, Humphrey P, Smith D, Harmon T, Shepherd D, Keetch D, Catalona W. Percentage of Free Serum Prostate-Specific Antigen as a Predictor of Pathologic Features of Prostate Cancer in a Screening Population fn1fn1This study was supported in part by a grant from Hybritech Incorporated, San Diego, California. Urology 1998, 51: 558-565. PMID: 9586607, DOI: 10.1016/s0090-4295(98)00035-1.Peer-Reviewed Original ResearchMeSH KeywordsAgedHumansMaleMass ScreeningMiddle AgedPredictive Value of TestsProstate-Specific AntigenProstatic NeoplasmsSensitivity and SpecificityConceptsProstate-specific antigenProstate cancerPathologic featuresFree serum prostate-specific antigenSerum prostate-specific antigenFree prostate-specific antigenCancerous surgical marginsProstate cancer screeningPercentage of cancerRadical prostatectomy specimenHarmless cancersPreoperative predictorsWatchful waitingSurgical marginsCapsular penetrationProstatic capsuleGleason scoreCancer screeningRadical prostatectomyProstatectomy specimenTumor volumeFPSAClinical practiceCancerScreening evaluation
1997
The early detection of prostate carcinoma with prostate specific antigen
Smith D, Humphrey P, Catalona W. The early detection of prostate carcinoma with prostate specific antigen. Cancer 1997, 80: 1852-1856. PMID: 9351559, DOI: 10.1002/(sici)1097-0142(19971101)80:9<1852::aid-cncr25>3.0.co;2-3.Peer-Reviewed Original ResearchMeSH KeywordsBiopsyHumansMaleMass ScreeningMiddle AgedPalpationProstate-Specific AntigenProstatic NeoplasmsWashingtonConceptsDigital rectal examinationSubset of menPositive predictive valueSignificant carcinomaPSA levelsRectal examinationProstate carcinomaPredictive valueScreening testDigital rectal examination resultsIntermediate outcomesCarcinoma detection rateEarly prostate carcinomaScreen-detected carcinomasScreen-detected tumorsInitial PSA levelReasonable positive predictive valueMajority of tumorsProstate-specific antigenProportion of menPathologic characteristicsClinicopathologic featuresPathologic featuresProstatic biopsyDisease stageUnusual Histologic Types of High-Grade Prostatic Intraepithelial Neoplasia
Reyes A, Swanson P, Carbone J, Humphrey P. Unusual Histologic Types of High-Grade Prostatic Intraepithelial Neoplasia. The American Journal Of Surgical Pathology 1997, 21: 1215-1222. PMID: 9331295, DOI: 10.1097/00000478-199710000-00013.Peer-Reviewed Original ResearchConceptsHigh-grade prostatic intraepithelial neoplasiaSignet ring cellsSmall cell carcinoma cellsProstatic intraepithelial neoplasiaProstate-specific antigenInvasive carcinomaIntraepithelial neoplasiaPrimary signet-ring cell carcinomaGrade prostatic intraepithelial neoplasiaSignet ring cell carcinomaCases of HGPINCarcinoma cellsNeuron-specific enolaseProstatic cell typesUnusual histologic typeSmall cell neuroendocrineGlandular epithelial cellsArchitectural growth patternIntraepithelial proliferationMucinous distensionCell typesMucinous featuresStrength of associationHistologic typeCell carcinomaThe Significance of Intraluminal Crystalloids in Benign Prostatic Glands on Needle Biopsy
Henneberry J, Kahane H, Humphrey P, Keetch D, Epstein J. The Significance of Intraluminal Crystalloids in Benign Prostatic Glands on Needle Biopsy. The American Journal Of Surgical Pathology 1997, 21: 725-728. PMID: 9199652, DOI: 10.1097/00000478-199706000-00014.Peer-Reviewed Original ResearchConceptsHigh-grade prostatic intraepithelial neoplasiaProstatic intraepithelial neoplasiaRepeat biopsyNeedle biopsyBenign glandsIntraluminal crystalloidsIntraepithelial neoplasiaBiopsy resultsSerum prostatic specific antigen (PSA) levelsSerum prostate-specific antigen valuesProstatic-specific antigen levelProstate-specific antigen valuesConsecutive needle biopsiesSpecific antigen levelsBenign prostatic glandsIncidence of cancerJohns Hopkins HospitalProstate biopsy resultsDianon SystemsConcurrent carcinomaSubsequent biopsyFirst biopsyAntigen levelsCystoprostatectomy specimensAntigen values
1996
Workgroup 4: Exploration of new pathologic factors in terms of potential for prognostic significance and future applications
von Eschenbach A, Brawer M, di Sant'Agnese P, Humphrey P, Mahran H, Murphy G, Sebo T, Veltri R. Workgroup 4: Exploration of new pathologic factors in terms of potential for prognostic significance and future applications. Cancer 1996, 78: 372-375. PMID: 8674021, DOI: 10.1002/(sici)1097-0142(19960715)78:2<372::aid-cncr31>3.0.co;2-r.Peer-Reviewed Original ResearchOptimized microvessel density analysis improves prediction of cancer stage from prostate needle biopsies
Bostwick D, Wheeler T, Blute M, Barrett D, MacLennan G, Sebo T, Scardino P, Humphrey P, Hudson M, Fradet Y, Miller G, Crawford E, Blumenstein B, Mahran H, Miles B. Optimized microvessel density analysis improves prediction of cancer stage from prostate needle biopsies. Urology 1996, 48: 47-57. PMID: 8693651, DOI: 10.1016/s0090-4295(96)00149-5.Peer-Reviewed Original ResearchClinical and Pathological Features of Hereditary Prostate Cancer
Keetch D, Humphrey P, Smith D, Stahl D, Catalona W. Clinical and Pathological Features of Hereditary Prostate Cancer. Journal Of Urology 1996, 155: 1841-1843. PMID: 8618269, DOI: 10.1016/s0022-5347(01)66024-5.Peer-Reviewed Original ResearchMeSH KeywordsAge of OnsetHumansMaleMiddle AgedNeoplasm StagingProstateProstate-Specific AntigenProstatectomyProstatic NeoplasmsRetrospective StudiesRisk FactorsConceptsHereditary prostate cancerSporadic prostate cancerProstate cancerPathological featuresGleason scoreSerum prostate-specific antigen (PSA) concentrationProstate-specific antigen concentrationDate of surgeryMean Gleason scoreSpecific antigen concentrationLow Gleason scoreHereditary diseaseRadical prostatectomy specimensFamily historyPathological differencesProstatectomy specimensMedian percentageSporadic carcinomasCancerAntigen concentrationSporadic cancersCarcinomaMenDiseaseScoresProspective characterization of pathological features of Prostatic Carcinomas Detected Via Serum Prostate Specific Antigen Based Screening
Humphrey P, Keetch D, Smith D, Shepherd D, Catalona W. Prospective characterization of pathological features of Prostatic Carcinomas Detected Via Serum Prostate Specific Antigen Based Screening. Journal Of Urology 1996, 155: 816-820. PMID: 8583583, DOI: 10.1016/s0022-5347(01)66316-x.Peer-Reviewed Original ResearchMeSH KeywordsAgedHumansMaleMass ScreeningMiddle AgedProspective StudiesProstate-Specific AntigenProstatic NeoplasmsConceptsProstate-specific antigenSerum prostate-specific antigenPathological featuresProstatic carcinomaSpecific antigenOrgan-confined prostate carcinomaCancerous surgical marginsGleason histological gradeIntraglandular tumor extentMost prostatic cancersMost prostatic carcinomasSurgical margin statusRadical prostatectomy specimensExtracapsular carcinomaAdvanced diseaseMargin statusSurgical marginsGleason scoreHistological gradePathological stageSurgical specimenProspective dataProstatic cancerTumor extentProspective characterization
1995
Morphometric Analysis and Clinical Followup of Isolated Prostatic Intraepithelial Neoplasia in Needle Biopsy of the Prostate
Keetch D, Humphrey P, Stahl D, Smith D, Catalona W. Morphometric Analysis and Clinical Followup of Isolated Prostatic Intraepithelial Neoplasia in Needle Biopsy of the Prostate. Journal Of Urology 1995, 154: 347-351. DOI: 10.1016/s0022-5347(01)67044-7.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiopsy, NeedleFollow-Up StudiesHumansLogistic ModelsMaleMiddle AgedProstate-Specific AntigenProstatic NeoplasmsConceptsProstatic intraepithelial neoplasiaHigh-grade prostatic intraepithelial neoplasiaGrade prostatic intraepithelial neoplasiaSerum PSA concentrationRepeat biopsyIntraepithelial neoplasiaProstate needle biopsyProstate-specific antigenNeedle biopsyInitial biopsyProstate cancerNumber of fociElevated serum PSA concentrationInitial prostate needle biopsyPSA concentrationMen 50 yearsPredictors of cancerDigital rectal examinationInitial biopsy specimenCancer detection rateFinding of cancerSignificance of gradeClinical followupPSA densityPatient ageMorphometric Analysis and Clinical Followup of Isolated Prostatic Intraepithelial Neoplasia in Needle Biopsy of the Prostate
Keetch D, Humphrey P, Stahl D, Smith D, Catalona W. Morphometric Analysis and Clinical Followup of Isolated Prostatic Intraepithelial Neoplasia in Needle Biopsy of the Prostate. Journal Of Urology 1995, 154: 347-351.. PMID: 7541850, DOI: 10.1097/00005392-199508000-00003.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiopsy, NeedleFollow-Up StudiesHumansLogistic ModelsMaleMiddle AgedProstate-Specific AntigenProstatic NeoplasmsConceptsProstatic intraepithelial neoplasiaHigh-grade prostatic intraepithelial neoplasiaGrade prostatic intraepithelial neoplasiaSerum PSA concentrationRepeat biopsyIntraepithelial neoplasiaProstate needle biopsyProstate-specific antigenNeedle biopsyInitial biopsyProstate cancerNumber of fociElevated serum PSA concentrationInitial prostate needle biopsyPSA concentrationMen 50 yearsPredictors of cancerDigital rectal examinationInitial biopsy specimenCancer detection rateFinding of cancerSignificance of gradeClinical followupPSA densityPatient ageEffect of Inflammation and Benign Prostatic Hyperplasia on Elevated Serum Prostate Specific Antigen Levels
Nadler R, Humphrey P, Smith D, Catalona W, Ratliff T. Effect of Inflammation and Benign Prostatic Hyperplasia on Elevated Serum Prostate Specific Antigen Levels. Journal Of Urology 1995, 154: 407-413. DOI: 10.1016/s0022-5347(01)67064-2.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overHumansMaleMiddle AgedMultivariate AnalysisProstate-Specific AntigenProstatic HyperplasiaProstatitisUltrasonographyConceptsHigh PSA groupMultiple negative biopsiesSerum PSA concentrationNegative biopsyRectal examinationPSA groupElevated serum prostate-specific antigen concentrationSerum prostate-specific antigen levelSerum prostate-specific antigen (PSA) concentrationElevated serum prostate-specific antigen (PSA) levelPSA concentrationProstate-specific antigen levelProstate-specific antigen concentrationSubclinical prostatic inflammationSuspicious rectal examinationDetectable prostate cancerSpecific antigen levelsDigital rectal examinationSpecific antigen concentrationBenign prostatic hyperplasiaEffects of inflammationProstatic inflammationPSA elevationProstate volumeAntigen levelsEffect of Inflammation and Benign Prostatic Hyperplasia on Elevated Serum Prostate Specific Antigen Levels
Nadler R, Humphrey P, Smith D, Catalona W, Ratliff T. Effect of Inflammation and Benign Prostatic Hyperplasia on Elevated Serum Prostate Specific Antigen Levels. Journal Of Urology 1995, 154: 407-413.. PMID: 7541857, DOI: 10.1097/00005392-199508000-00023.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overHumansMaleMiddle AgedMultivariate AnalysisProstate-Specific AntigenProstatic HyperplasiaProstatitisUltrasonographyConceptsHigh PSA groupMultiple negative biopsiesSerum PSA concentrationNegative biopsyProstate volumeRectal examinationPSA groupElevated serum prostate-specific antigen concentrationSerum prostate-specific antigen levelSerum prostate-specific antigen (PSA) concentrationElevated serum prostate-specific antigen (PSA) levelPSA concentrationProstate-specific antigen levelProstate-specific antigen concentrationSubclinical prostatic inflammationSuspicious rectal examinationDetectable prostate cancerSpecific antigen levelsDigital rectal examinationSpecific antigen concentrationBenign prostatic hyperplasiaEffects of inflammationProstatic inflammationPSA elevationAntigen levels
1993
Stratification of pathologic features in radical prostatectomy specimens that are predictive of elevated initial postoperative serum prostate‐specific antigen levels
Humphrey P, Frazier H, Vollmer R, Paulson D. Stratification of pathologic features in radical prostatectomy specimens that are predictive of elevated initial postoperative serum prostate‐specific antigen levels. Cancer 1993, 71: 1821-1827. PMID: 7680602, DOI: 10.1002/1097-0142(19930301)71:5<1821::aid-cncr2820710517>3.0.co;2-o.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaHumansLogistic ModelsMaleMultivariate AnalysisPredictive Value of TestsProstateProstate-Specific AntigenProstatectomyProstatic NeoplasmsConceptsPostoperative PSA levelPostoperative serum PSA levelsSerum PSA levelsRadical prostatectomy specimensIntraglandular tumor extentPSA levelsPathologic stageMargin positivityProstate-specific antigenHistologic gradeProstatectomy specimensResidual carcinomaPathologic featuresTumor extentSerum prostate-specific antigen levelPercentage carcinomaProstate-specific antigen levelExtension of carcinomaGleason histologic gradeOrgan-confined carcinomaLogistic regression analysisImportant morphologic parametersIntraglandular carcinomaAntigen levelsRadical prostatectomy