2016
Konsenskonferenz 2014 der ISUP zur Gleason-Graduierung des Prostatakarzinoms
Kristiansen G, Egevad L, Amin M, Delahunt B, Srigley J, Humphrey P, Epstein J, Graduierungskommittee. Konsenskonferenz 2014 der ISUP zur Gleason-Graduierung des Prostatakarzinoms. Die Pathologie 2016, 37: 17-26. PMID: 26809207, DOI: 10.1007/s00292-015-0136-6.Peer-Reviewed Original Research
2015
NFATc1 promotes prostate tumorigenesis and overcomes PTEN loss-induced senescence
Manda K, Tripathi P, Hsi A, Ning J, Ruzinova M, Liapis H, Bailey M, Zhang H, Maher C, Humphrey P, Andriole G, Ding L, You Z, Chen F. NFATc1 promotes prostate tumorigenesis and overcomes PTEN loss-induced senescence. Oncogene 2015, 35: 3282-3292. PMID: 26477312, PMCID: PMC5012433, DOI: 10.1038/onc.2015.389.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCell LineCell Line, TumorCell ProliferationCell Transformation, NeoplasticCellular SenescenceCytokinesGene Expression Regulation, NeoplasticHumansImmunohistochemistryMaleMice, KnockoutMice, NudeMice, TransgenicNFATC Transcription FactorsProstateProstatic NeoplasmsPTEN PhosphohydrolaseReverse Transcriptase Polymerase Chain ReactionTransplantation, HomologousTumor Cells, CulturedTumor MicroenvironmentConceptsProstate tumorigenesisHuman PCaNFATc1 activationNon-tumorigenic prostate cellsActivated T cells c1Cultured PCa cellsT cells c1Cellular senescenceRole of NFATc1Number of cytokinesActivation of NFATc1Proinflammatory cytokinesPCa cellsProstate cancerProstatic adenocarcinomaLuminal epitheliumMouse prostateCells c1Normal prostateOncogenic roleOncogene c-mycProstate tissueProstate cellsSoluble factorsNuclear factor
2009
Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis
Song H, Zhang B, Watson M, Humphrey P, Lim H, Milbrandt J. Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis. Oncogene 2009, 28: 3307-3319. PMID: 19597465, PMCID: PMC2746257, DOI: 10.1038/onc.2009.181.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtrophyClusterinDisease Models, AnimalDisease ProgressionDown-RegulationGene DeletionGene Expression ProfilingGene Expression Regulation, NeoplasticHomeodomain ProteinsHumansLasersMaleMiceMicrodissectionOxidoreductases Acting on Sulfur Group DonorsProstateProstatic NeoplasmsProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-mycPTEN PhosphohydrolaseSignal TransductionThioredoxinsTranscription FactorsTranscription, GeneticTranscriptional ActivationConceptsNKX3.1 lossMolecular consequencesGene expressionProstate tumorigenesisPTEN-AKTCancer initiationProstate cancer initiationCohort of genesNumber of genesC-Myc signaling pathwayDownstream target genesHuman prostate tumorigenesisLoss of NKX3.1NKX3.1 expressionTumor suppressor geneGene expression data setsExpression data setsQuiescin Q6Transcriptional regulatorsIndependent lossesExpression of NKX3.1Laser capture microdissectionTarget genesCancer gene expression data setsSignaling pathways
2004
EFFECT OF THE DUAL 5α-REDUCTASE INHIBITOR DUTASTERIDE ON MARKERS OF TUMOR REGRESSION IN PROSTATE CANCER
ANDRIOLE G, HUMPHREY P, RAY P, GLEAVE M, TRACHTENBERG J, THOMAS L, LAZIER C, RITTMASTER R. EFFECT OF THE DUAL 5α-REDUCTASE INHIBITOR DUTASTERIDE ON MARKERS OF TUMOR REGRESSION IN PROSTATE CANCER. Journal Of Urology 2004, 172: 915-919. PMID: 15310997, DOI: 10.1097/01.ju.0000136430.37245.b9.Peer-Reviewed Original ResearchConceptsProstate cancerMicrovessel densityDutasteride treatmentIntraprostatic dihydrotestosteroneTumor regressionDual 5α-Reductase Inhibitor DutasterideShort-term pilot studyDays of placeboEffect of dutasterideIntraprostatic androgen levelsT2 prostate cancerDegree of atrophyProstate cancer treatmentShort-term treatmentProstate cancer tissuesIndex of apoptosisRadical prostatectomyEarly treatmentAndrogen levelsDutasterideCancer tissuesResected tissuesDHT formationDihydrotestosteroneType 1
2001
Interobserver reproducibility of Gleason grading of prostatic carcinoma: Urologic pathologists
Allsbrook W, Mangold K, Johnson M, Lane R, Lane C, Amin M, Bostwick D, Humphrey P, Jones E, Reuter V, Sakr W, Sesterhenn I, Troncoso P, Wheeler T, Epstein J. Interobserver reproducibility of Gleason grading of prostatic carcinoma: Urologic pathologists. Human Pathology 2001, 32: 74-80. PMID: 11172298, DOI: 10.1053/hupa.2001.21134.Peer-Reviewed Original ResearchConceptsUrologic pathologistsProstatic carcinomaInterobserver reproducibilityGleason scoreGleason gradingGleason grade groupLow-grade tumorsCribriform proliferationNeedle biopsyGroup 2Gleason patternGrading systemCarcinomaGrade groupTumorsPathologistsScoresGradingKappa coefficientBiopsyHistologyCoefficient kappa
2000
Overexpression and regulation of expression of scatter factor/hepatocyte growth factor in prostatic carcinoma
Zhu X, Humphrey P. Overexpression and regulation of expression of scatter factor/hepatocyte growth factor in prostatic carcinoma. Urology 2000, 56: 1071-1074. PMID: 11113771, DOI: 10.1016/s0090-4295(00)00795-0.Peer-Reviewed Original ResearchConceptsPlatelet-derived growth factorVascular endothelial growth factorHGF expressionSF/HGF expressionEndothelial growth factorGrowth factorProstatic carcinomaIL-1betaStromal myofibroblastsProstatic tissueSF/HGFCarcinoma tissuesGrowth factors basic fibroblast growth factorCell linesProstatic epithelial cell linesHuman prostatic carcinoma tissueHuman prostatic tissue samplesProstatic tissue samplesProstatic carcinoma tissueBenign prostatic tissueHuman prostatic carcinomaHuman prostatic tissueMalignant human prostatic tissuesMultifunctional polypeptide growth factorsEnzyme-linked immunosorbent
1998
A transgenic mouse model of metastatic prostate cancer originating from neuroendocrine cells
Garabedian E, Humphrey P, Gordon J. A transgenic mouse model of metastatic prostate cancer originating from neuroendocrine cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 15382-15387. PMID: 9860977, PMCID: PMC28051, DOI: 10.1073/pnas.95.26.15382.Peer-Reviewed Original ResearchConceptsMetastatic prostate cancerProstatic intraepithelial neoplasiaTransgenic mouse modelProstate cancerIntraepithelial neoplasiaMouse modelNeuroendocrine cellsHuman prostate cancerNeuroendocrine cell lineagesWeeks of ageNeuroendocrine differentiationSimian virus 40 T antigenLocal invasionMouse prostateCancerNeoplasiaProstateWeeksT antigenCell lineagesTransgene expressionMultiple pedigreesCellsMetastasisAndrogensPseudohyperplastic Prostatic Adenocarcinoma
Humphrey P, Kaleem Z, Swanson P, Vollmer R. Pseudohyperplastic Prostatic Adenocarcinoma. The American Journal Of Surgical Pathology 1998, 22: 1239-1246. PMID: 9777986, DOI: 10.1097/00000478-199810000-00009.Peer-Reviewed Original ResearchConceptsCases of adenocarcinomaProstatic adenocarcinomaHyperplastic featuresNeedle biopsyProstate carcinoma growthUsual epithelial hyperplasiaProstatic needle biopsyLow Gleason scoreLow-grade carcinomaRadical prostatectomy specimensRadical prostatectomy tissueGleason pattern 2Cystic dilatationPathologic stagePrognostic implicationsTumor sizeGleason scoreHistologic gradePapillary infoldingsRadical prostatectomyUsual hyperplasiaHistologic variantsPrognostic informationProstatic carcinomaCarcinomatous fociDiagnostic Effect of Complete Histologic Sampling of Prostate Needle Biopsy Specimens
Reyes A, Humphrey P. Diagnostic Effect of Complete Histologic Sampling of Prostate Needle Biopsy Specimens. American Journal Of Clinical Pathology 1998, 109: 416-422. PMID: 9535395, DOI: 10.1093/ajcp/109.4.416.Peer-Reviewed Original ResearchConceptsHigh-grade PINProstate needle biopsy specimensFocal glandular atypiaNeedle biopsy tissueNeedle biopsy specimensBenign prostatic tissueAdditional slidesHistologic abnormalitiesBiopsy specimensGlandular atypiaHistologic samplingNeedle biopsyProstatic tissueBiopsy tissueProstate needle core biopsiesNeedle core biopsyProstate needle biopsyComplete histopathologic examinationDetection of carcinomaDiagnostic effectComplete histologic examinationAdditional histologicProspective studyDefinitive diagnosisHistopathologic examination
1997
The Significance of Intraluminal Crystalloids in Benign Prostatic Glands on Needle Biopsy
Henneberry J, Kahane H, Humphrey P, Keetch D, Epstein J. The Significance of Intraluminal Crystalloids in Benign Prostatic Glands on Needle Biopsy. The American Journal Of Surgical Pathology 1997, 21: 725-728. PMID: 9199652, DOI: 10.1097/00000478-199706000-00014.Peer-Reviewed Original ResearchConceptsHigh-grade prostatic intraepithelial neoplasiaProstatic intraepithelial neoplasiaRepeat biopsyNeedle biopsyBenign glandsIntraluminal crystalloidsIntraepithelial neoplasiaBiopsy resultsSerum prostatic specific antigen (PSA) levelsSerum prostate-specific antigen valuesProstatic-specific antigen levelProstate-specific antigen valuesConsecutive needle biopsiesSpecific antigen levelsBenign prostatic glandsIncidence of cancerJohns Hopkins HospitalProstate biopsy resultsDianon SystemsConcurrent carcinomaSubsequent biopsyFirst biopsyAntigen levelsCystoprostatectomy specimensAntigen values
1996
Clinical and Pathological Features of Hereditary Prostate Cancer
Keetch D, Humphrey P, Smith D, Stahl D, Catalona W. Clinical and Pathological Features of Hereditary Prostate Cancer. Journal Of Urology 1996, 155: 1841-1843. PMID: 8618269, DOI: 10.1016/s0022-5347(01)66024-5.Peer-Reviewed Original ResearchConceptsHereditary prostate cancerSporadic prostate cancerProstate cancerPathological featuresGleason scoreSerum prostate-specific antigen (PSA) concentrationProstate-specific antigen concentrationDate of surgeryMean Gleason scoreSpecific antigen concentrationLow Gleason scoreHereditary diseaseRadical prostatectomy specimensFamily historyPathological differencesProstatectomy specimensMedian percentageSporadic carcinomasCancerAntigen concentrationSporadic cancersCarcinomaMenDiseaseScores
1994
Development of a Mouse Model for Nonbacterial Prostatitis
Keetch D, Humphrey P, Ratliff T. Development of a Mouse Model for Nonbacterial Prostatitis. Journal Of Urology 1994, 152: 247-250. PMID: 8201676, DOI: 10.1016/s0022-5347(17)32871-9.Peer-Reviewed Original ResearchConceptsNonbacterial prostatitisProstatic inflammationC57BL/6-lpr miceLpr miceBALB/c miceAdoptive transfer studiesCommon clinical entityDegree of inflammationBALB/cPeriglandular regionsAutoimmune processAJ miceLymphocytic infiltrationC57BL/6 miceClinical entityProstate antigenC miceImmune parametersSyngeneic miceProstatitisMouse modelProstatic tissueDisease processAnimal modelsInflammation
1993
Atypical adenomatous hyperplasia of the prostate: Morphologic criteria for its distinction from well-differentiated carcinoma
Bostwick D, Srigley J, Grignon D, Maksem J, Humphrey P, van der Kwast T, Bose D, Harrison J, Young R. Atypical adenomatous hyperplasia of the prostate: Morphologic criteria for its distinction from well-differentiated carcinoma. Human Pathology 1993, 24: 819-832. PMID: 8375853, DOI: 10.1016/0046-8177(93)90131-y.Peer-Reviewed Original ResearchStratification of pathologic features in radical prostatectomy specimens that are predictive of elevated initial postoperative serum prostate‐specific antigen levels
Humphrey P, Frazier H, Vollmer R, Paulson D. Stratification of pathologic features in radical prostatectomy specimens that are predictive of elevated initial postoperative serum prostate‐specific antigen levels. Cancer 1993, 71: 1821-1827. PMID: 7680602, DOI: 10.1002/1097-0142(19930301)71:5<1821::aid-cncr2820710517>3.0.co;2-o.Peer-Reviewed Original ResearchConceptsPostoperative PSA levelPostoperative serum PSA levelsSerum PSA levelsRadical prostatectomy specimensIntraglandular tumor extentPSA levelsPathologic stageMargin positivityProstate-specific antigenHistologic gradeProstatectomy specimensResidual carcinomaPathologic featuresTumor extentSerum prostate-specific antigen levelPercentage carcinomaProstate-specific antigen levelExtension of carcinomaGleason histologic gradeOrgan-confined carcinomaLogistic regression analysisImportant morphologic parametersIntraglandular carcinomaAntigen levelsRadical prostatectomy
1992
Immunoreactive Prostatic Specific Antigen in Male Periurethral Glands
Frazier H, Humphrey P, Burchette J, Paulson D. Immunoreactive Prostatic Specific Antigen in Male Periurethral Glands. Journal Of Urology 1992, 147: 246-248. PMID: 1370330, DOI: 10.1016/s0022-5347(17)37206-3.Peer-Reviewed Original ResearchConceptsProstatic specific antigenProstatic acid phosphatasePeriurethral glandsSpecific antigenUrethral specimensMalignant prostatic tissueMale urethral specimensAutopsy seriesUrethral biopsyProstatic cancerAntigen uniqueAutopsy specimensProstatic tissueStrong immunostainingHeterogenous stainingAntigenAcid phosphataseRecent evidenceGlandTissueBiopsyEvidencePatientsCancerImmunostaining
1991
Histologic Grade, DNA Ploidy, and Intraglandular Tumor Extent as Indicators of Tumor Progression of Clinical Stage B Prostatic Carcinoma
Humphrey P, Walther P, Currin S, Vollmer R. Histologic Grade, DNA Ploidy, and Intraglandular Tumor Extent as Indicators of Tumor Progression of Clinical Stage B Prostatic Carcinoma. The American Journal Of Surgical Pathology 1991, 15: 1165-1170. PMID: 1746683, DOI: 10.1097/00000478-199112000-00007.Peer-Reviewed Original ResearchConceptsHistologic gradeDNA ploidyTumor progressionTumor areaClinical stage B adenocarcinomaIntraglandular tumor extentStage B adenocarcinomaIndependent predictive factorsCox model analysisLikelihood of aneuploidyLogistic regression modelsB adenocarcinomaPredictive factorsTumor extensionProstatic carcinomaTumor extentProstatectomy specimensMultivariate analysisConcurrent useProgressionAdditional predictive abilityProstateImportant predictorRegression models
1988
The ratio of prostate chips with cancer:A new measure of tumor extent and its relationship to grade and prognosis
Humphrey P, Vollmer R. The ratio of prostate chips with cancer:A new measure of tumor extent and its relationship to grade and prognosis. Human Pathology 1988, 19: 411-418. PMID: 3366451, DOI: 10.1016/s0046-8177(88)80490-8.Peer-Reviewed Original ResearchConceptsProstate cancerAdditive prognostic informationStage of tumorGleason histologic scoreChoice of patientsChance of deathCurative surgeryExtensive diseaseLocalized diseaseTransurethral prostatectomyGleason scoreProstate chipsPrognostic informationTumor extentHistologic scoresPatientsCancerLong-term failureDiseaseReliable predictorScoresInitial studyTotal numberPrognosticatorProstatectomy