2001
Defective Antigen Processing in GILT-Free Mice
Maric M, Arunachalam B, Phan U, Dong C, Garrett W, Cannon K, Alfonso C, Karlsson L, Flavell R, Cresswell P. Defective Antigen Processing in GILT-Free Mice. Science 2001, 294: 1361-1365. PMID: 11701933, DOI: 10.1126/science.1065500.Peer-Reviewed Original ResearchAmino Acid SequenceAnimalsAntigen PresentationAntigen-Presenting CellsAntigensCell LineDendritic CellsDisulfidesEpitopesHistocompatibility Antigens Class IIHybridomasHydrogen-Ion ConcentrationImmunizationMiceMice, Inbred C57BLMice, KnockoutMolecular Sequence DataMuramidaseOxidoreductasesOxidoreductases Acting on Sulfur Group DonorsProtein ConformationProtein FoldingSpleenT-LymphocytesMaintenance of TCR clonality in T cells expressing genes for two TCR heterodimers
Sant'Angelo D, Cresswell P, Janeway C, Denzin L. Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 6824-6829. PMID: 11381132, PMCID: PMC34437, DOI: 10.1073/pnas.121179998.Peer-Reviewed Original ResearchConceptsAllelic exclusionTCR heterodimerTCR proteinsCell surface expressionTCR lociT cellsCell surfaceFurther recombinationProteinAlpha chainBeta chainHeterodimersSurface expressionTransgenic miceTCR transgenic miceCellsAdditional mechanismExpressionTCR clonalityAssembly processGenesSecond TCRLociRNATCRGlycosylation and the Immune System
Rudd P, Elliott T, Cresswell P, Wilson I, Dwek R. Glycosylation and the Immune System. Science 2001, 291: 2370-2376. PMID: 11269318, DOI: 10.1126/science.291.5512.2370.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAntigen-Antibody ReactionsAntigen-Presenting CellsAntigens, CD1Carrier ProteinsCollectinsComplement System ProteinsEndoplasmic ReticulumEpitopesGlycoproteinsGlycosylationHistocompatibility AntigensHumansImmune SystemImmunoglobulinsPolysaccharidesProtein FoldingT-LymphocytesViral Envelope ProteinsConceptsImmune systemMajor histocompatibility complex antigensAntigen-presenting cellsAdaptive immune responsesCellular immune systemHistocompatibility complex antigensHumoral immune systemT cell receptor complexRheumatoid arthritisMannose-binding lectinAutoimmune diseasesCell receptor complexT cellsImmune responseComplex antigensPeptide antigensComplement componentsImmunoglobulin GAntigenKey moleculesReceptor complexSpecific glycoformsGlycoproteinGlycopeptide antigensArthritis
1999
Human epidermal Langerhans cells lack functional mannose receptors and a fully developed endosomal/lysosomal compartment for loading of HLA class II molecules
Mommaas A, Mulder A, Jordens R, Out C, Tan M, Cresswell P, Kluin P, Koning F. Human epidermal Langerhans cells lack functional mannose receptors and a fully developed endosomal/lysosomal compartment for loading of HLA class II molecules. European Journal Of Immunology 1999, 29: 571-580. PMID: 10064073, DOI: 10.1002/(sici)1521-4141(199902)29:02<571::aid-immu571>3.0.co;2-e.Peer-Reviewed Original ResearchConceptsHuman epidermal Langerhans cellsEpidermal Langerhans cellsLangerhans cellsT cellsAntigen-specific T cellsMannose receptorPeripheral blood mononuclear cellsHLA class II moleculesProtein antigensBlood-derived DCsBlood mononuclear cellsAntigen-presenting cellsNaive T cellsDendritic cell lineageClass II moleculesClass II compartmentsFunctional mannose receptorsLymph nodesAntigen uptakeMononuclear cellsMHC classEndocytic capacitySkin damageReceptor-mediated endocytosis pathwayAntigen
1998
Assembly of MHC class I molecules with biosynthesized endoplasmic reticulum-targeted peptides is inefficient in insect cells and can be enhanced by protease inhibitors.
Deng Y, Gibbs J, Bačík I, Porgador A, Copeman J, Lehner P, Ortmann B, Cresswell P, Bennink J, Yewdell J. Assembly of MHC class I molecules with biosynthesized endoplasmic reticulum-targeted peptides is inefficient in insect cells and can be enhanced by protease inhibitors. The Journal Of Immunology 1998, 161: 1677-85. PMID: 9712031, DOI: 10.4049/jimmunol.161.4.1677.Peer-Reviewed Original ResearchMeSH KeywordsAedesAnimalsAntibodies, MonoclonalAntiportersCell LineEndoplasmic ReticulumH-2 AntigensHeLa CellsHumansImmunoglobulinsLymphocyte ActivationMacromolecular SubstancesMembrane Transport ProteinsMiceOligopeptidesOvalbuminPeptide FragmentsProtease InhibitorsRecombinant ProteinsT-LymphocytesVaccinia virusConceptsInsect cellsEndoplasmic reticulumVertebrate cellsHuman cellsHuman tapasinVaccinia virus-mediated expressionCell surface expressionProtease inhibitorsInefficient assemblyKbMHC class IMouse betaInsectsEfficient assemblyImmediate precursorSurface expressionAntigenic peptidesHeavy chainClass IRecombinant vaccinia virusVirus-mediated expressionAssemblyExpressionCellsVaccinia virus
1997
Negative Regulation by HLA-DO of MHC Class II-Restricted Antigen Processing
Denzin L, Sant'Angelo D, Hammond C, Surman M, Cresswell P. Negative Regulation by HLA-DO of MHC Class II-Restricted Antigen Processing. Science 1997, 278: 106-109. PMID: 9311912, DOI: 10.1126/science.278.5335.106.Peer-Reviewed Original ResearchConceptsHLA-DOII-like moleculeAntigen processingClass IIHLA-DMMajor histocompatibility complex classMHC class IIHistocompatibility complex classClass II moleculesII-CLIP complexesHLA-DM functionT cell linesB cellsChain-derived peptideAntigenic peptidesImportant modulatorCell linesDM functionInvariant chain-derived peptidesComplex classNegative regulationPeptides
1995
HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading
Denzin L, Cresswell P. HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading. Cell 1995, 82: 155-165. PMID: 7606781, DOI: 10.1016/0092-8674(95)90061-6.Peer-Reviewed Original Research
1992
Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules
Arnold D, Driscoll J, Androlewicz M, Hughes E, Cresswell P, Spies T. Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules. Nature 1992, 360: 171-174. PMID: 1436094, DOI: 10.1038/360171a0.Peer-Reviewed Original ResearchAntigen-Antibody ReactionsAntigens, ViralATP Binding Cassette Transporter, Subfamily B, Member 2ATP Binding Cassette Transporter, Subfamily B, Member 3ATP-Binding Cassette TransportersCarrier ProteinsCell LineChromatography, High Pressure LiquidCysteine EndopeptidasesElectrophoresis, Gel, Two-DimensionalHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHLA-A AntigensHLA-B AntigensHumansMembrane ProteinsMultienzyme ComplexesProteasome Endopeptidase ComplexProteinsT-LymphocytesTransfectionViral Matrix Proteins
1990
Isolation and characterization of a galactose-specific carbohydrate binding protein from human lymphoblastic cells
Baum L, Cresswell P. Isolation and characterization of a galactose-specific carbohydrate binding protein from human lymphoblastic cells. Biochemical And Biophysical Research Communications 1990, 173: 1079-1085. PMID: 2268313, DOI: 10.1016/s0006-291x(05)80896-4.Peer-Reviewed Original ResearchThe transport of class I major histocompatibility complex antigens is determined by sequences in the α1 and α2 protein domains
Alexander J, Payne J, Shigekawa B, Frelinger J, Cresswell P. The transport of class I major histocompatibility complex antigens is determined by sequences in the α1 and α2 protein domains. Immunogenetics 1990, 31: 169-178. PMID: 2318516, DOI: 10.1007/bf00211552.Peer-Reviewed Original ResearchAmino Acid SequenceAnimalsAntigens, SurfaceBiological TransportCell LineElectricityElectrophoresis, Gel, Two-DimensionalExonsFlow CytometryGlycosylationHistocompatibility Antigens Class IHLA-B7 AntigenHumansMiceMolecular Sequence DataProtein ConformationProtein Processing, Post-TranslationalRecombinant ProteinsT-LymphocytesTransfectionCo-localization of molecules involved in antigen processing and presentation in an early endocytic compartment
Guagliardi L, Koppelman B, Blum J, Marks M, Cresswell P, Brodsky F. Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment. Nature 1990, 343: 133-139. PMID: 2404209, DOI: 10.1038/343133a0.Peer-Reviewed Original Research
1985
Evidence for methylation as a regulatory mechanism in HLA-DRx gene expression
Carrington M, Salter R, Cresswell P, Ting J. Evidence for methylation as a regulatory mechanism in HLA-DRx gene expression. Immunogenetics 1985, 22: 219-229. PMID: 2995246, DOI: 10.1007/bf00404481.Peer-Reviewed Original ResearchConceptsGene expressionDNA methylationLymphoblastoid cell linesRegulatory mechanismsDNA hypomethylationParental linesHybrid linesSomatic cell hybridsRestriction enzyme Hpa IIHpa II digestionMsp I siteDifferent regulatory mechanismsCell hybridsGenomic probesGene inductionUnexpressed genesComplete demethylationHpa IIGenesDR genesMethylationT-LCLCell linesI siteHypomethylationGenes regulating HLA class I antigen expression in T-B lymphoblast hybrids
Salter R, Howell D, Cresswell P. Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids. Immunogenetics 1985, 21: 235-246. PMID: 3872841, DOI: 10.1007/bf00375376.Peer-Reviewed Original ResearchMeSH KeywordsB-LymphocytesFlow CytometryGene Expression RegulationHLA AntigensHumansHybrid CellsT-LymphocytesConceptsHLA class IClass II antigen expressionClass II antigensHLA-B antigensClass III antigensAntigen expressionLymphoblastoid cell linesTotal HLA class IHLA class II antigensHLA-A2 antigenHLA-B5 antigenHLA-A antigensB-lymphoblastoid cell linesCell linesHLA-DRHLA-B5HLA-A2B-LCLParental cell lineAntigenEnhanced expressionDecreased amountCEMRChromosome 6
1984
Expression of class I histocompatibility antigens on human T-B lymphoblast hybrids
Howell D, Kostyu D, Ting J, Cresswell P. Expression of class I histocompatibility antigens on human T-B lymphoblast hybrids. Somatic Cell And Molecular Genetics 1984, 10: 217-224. PMID: 6609440, DOI: 10.1007/bf01535244.Peer-Reviewed Original ResearchConceptsClass I histocompatibilityB-LCLLymphoblastoid cell linesB antigensPaucity of HLAHLA class I heavy chainsHLA-B antigensHLA-A antigensB-lymphoblastoid cell linesB antigen expressionClass I heavy chainsAntigen expressionB expressionHLAIndirect immunofluorescenceAntigenLow levelsClass IT-LCLHistocompatibilityCell linesHeavy chain mRNATotal levelsCEMRHeavy chain
1983
Expression of T-lymphoblast-encoded HLA-DR, MT, and SB antigens on human T-B lymphoblast hybrids
Howell D, Hartzman R, Cresswell P. Expression of T-lymphoblast-encoded HLA-DR, MT, and SB antigens on human T-B lymphoblast hybrids. Human Immunology 1983, 8: 167-175. PMID: 6417070, DOI: 10.1016/0198-8859(83)90011-3.Peer-Reviewed Original ResearchExpression of T-lymphoblast-encoded HLA-DR antigens on human T-B lymphoblast hybrids
Howell D, Cresswell P. Expression of T-lymphoblast-encoded HLA-DR antigens on human T-B lymphoblast hybrids. Immunogenetics 1983, 17: 411-425. PMID: 6601057, DOI: 10.1007/bf00372459.Peer-Reviewed Original Research
1982
Human T-B lymphoblast hybrids express HLA-DR specificities not expressed by either parent
Howell D, Berger A, Cresswell P. Human T-B lymphoblast hybrids express HLA-DR specificities not expressed by either parent. Immunogenetics 1982, 15: 199-206. PMID: 6977490, DOI: 10.1007/bf00621951.Peer-Reviewed Original ResearchExpression of cell surface lectins on activated human lymphoid cells
Apgar J, Cresswell P. Expression of cell surface lectins on activated human lymphoid cells. European Journal Of Immunology 1982, 12: 570-576. PMID: 6214410, DOI: 10.1002/eji.1830120708.Peer-Reviewed Original Research
1981
A human leukocyte antigen identified by a monoclonal antibody
Berger A, Davis J, Cresswell P. A human leukocyte antigen identified by a monoclonal antibody. Human Immunology 1981, 3: 231-245. PMID: 6975769, DOI: 10.1016/0198-8859(81)90020-3.Peer-Reviewed Original ResearchConceptsLeukocyte antigenT cell linesB cell linesB lymphocytesCell linesMonoclonal antibodiesHuman leukocyte antigenPeripheral blood cellsBone marrow cellsAllogeneic cellsT cellsB cellsErythroid seriesMore antigensAntigenHuman leukocytesMarrow cellsBlood cellsNegative populationAntibodiesLymphocytesApproximate molecular weightCellsElectrophoretic mobilityMonocytes
1979
Transferrin receptors on human B and T lymphosblastoid cell lines
Larrick J, Cresswell P. Transferrin receptors on human B and T lymphosblastoid cell lines. Biochimica Et Biophysica Acta 1979, 583: 483-490. PMID: 218639, DOI: 10.1016/0304-4165(79)90065-5.Peer-Reviewed Original ResearchMeSH KeywordsB-LymphocytesBinding SitesCell LineHumansPapainReceptors, Cell SurfaceT-LymphocytesTransferrinTrypsin