2001
Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers
Sant'Angelo D, Cresswell P, Janeway C, Denzin L. Maintenance of TCR clonality in T cells expressing genes for two TCR heterodimers. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 6824-6829. PMID: 11381132, PMCID: PMC34437, DOI: 10.1073/pnas.121179998.Peer-Reviewed Original ResearchConceptsAllelic exclusionTCR heterodimerTCR proteinsCell surface expressionTCR lociT cellsCell surfaceFurther recombinationProteinAlpha chainBeta chainHeterodimersSurface expressionTransgenic miceTCR transgenic miceCellsAdditional mechanismExpressionTCR clonalityAssembly processGenesSecond TCRLociRNATCR
1987
Immune recognition of human major histocompatibility antigens: localization by a comprehensive synthetic strategy of the continuous antigenic sites in the first domain of HLA‐DR2 β chain
Ulrich R, Atassi H, Lutz P, Cresswell P, Atassi M. Immune recognition of human major histocompatibility antigens: localization by a comprehensive synthetic strategy of the continuous antigenic sites in the first domain of HLA‐DR2 β chain. European Journal Of Immunology 1987, 17: 497-502. PMID: 2436923, DOI: 10.1002/eji.1830170410.Peer-Reviewed Original ResearchConceptsAntibody-binding activityHuman major histocompatibility antigensBeta chainMajor histocompatibility antigensAntigenic sitesHistocompatibility antigensImmune recognitionChain antiserumIsolated beta chainsMost antiseraAntiserumPeptide 81Continuous antigenic sitesΒ-chainPeptidesFirst domainHLAImmunodominanceAntigenComprehensive synthetic strategy
1984
Analysis of monoclonal antibodies reactive with human class II beta chains by two-dimensional electrophoresis and western blotting
Radka S, Machamer C, Cresswell P. Analysis of monoclonal antibodies reactive with human class II beta chains by two-dimensional electrophoresis and western blotting. Human Immunology 1984, 10: 177-188. PMID: 6611328, DOI: 10.1016/0198-8859(84)90038-7.Peer-Reviewed Original ResearchConceptsMonomorphic monoclonal antibodiesClass II moleculesMonoclonal antibodiesBeta chainClass II beta chainPolymorphic monoclonal antibodiesHLA-DR5HLA-DRMonomorphic determinantsBeta subunitDeterminant absentPolymorphic antibodiesWestern blottingAntibodiesAntigen subunitsTwo-dimensional gel electrophoresisTwo-dimensional electrophoresisDR3HLA-DR7-Specific monoclonal antibodies and a chimpanzee anti-DR7 serum detect different epitopes on the same molecule
Radka S, Bernard Amos D, Quackenbush L, Cresswell P. HLA-DR7-Specific monoclonal antibodies and a chimpanzee anti-DR7 serum detect different epitopes on the same molecule. Immunogenetics 1984, 19: 63-76. PMID: 6198273, DOI: 10.1007/bf00364476.Peer-Reviewed Original ResearchConceptsClass II moleculesChimpanzee antiserumSame class II moleculesDR7 specificitiesSerologic specificityMonoclonal antibodiesBinding-inhibition studiesCell linesSame serologic specificityAllogeneic epitopesNoncytotoxic antibodiesHLA-DR7IgM antibodiesSpecific monoclonal antibodiesDR moleculesDifferent epitopesAntibodiesEpitopesBeta chainCytotoxic activityHomozygous cell linesAntiserumMembrane preparationsCytotoxicitySpecificity