2012
Sat1 is dispensable for active oxalate secretion in mouse duodenum
Ko N, Knauf F, Jiang Z, Markovich D, Aronson PS. Sat1 is dispensable for active oxalate secretion in mouse duodenum. American Journal Of Physiology - Cell Physiology 2012, 303: c52-c57. PMID: 22517357, PMCID: PMC3404526, DOI: 10.1152/ajpcell.00385.2011.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAcetazolamideAnimalsAnion Transport ProteinsAntiportersBiological Transport, ActiveDuodenumMiceMice, KnockoutOxalatesSulfate TransportersConceptsCalcium oxalate stonesMouse duodenumOxalate secretionOxalate stonesIntestinal oxalate secretionIntestinal oxalate transportSecretory fluxSAT1 expressionDisulfonic stilbene DIDSDuodenumTransporter 1SecretionMiceHyperoxalemiaBasolateral solutionHyperoxaluriaBasolateral transportersBicarbonate productionOxalate transportBasolateral membraneSAT1Apical membraneComplete removalMedium concentration
2009
Prestin's Anion Transport and Voltage-Sensing Capabilities Are Independent
Bai JP, Surguchev A, Montoya S, Aronson PS, Santos-Sacchi J, Navaratnam D. Prestin's Anion Transport and Voltage-Sensing Capabilities Are Independent. Biophysical Journal 2009, 96: 3179-3186. PMID: 19383462, PMCID: PMC2718310, DOI: 10.1016/j.bpj.2008.12.3948.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnalysis of VarianceAnimalsAnion Transport ProteinsAntiportersCarbon RadioisotopesChloridesCHO CellsCricetinaeCricetulusElectric CapacitanceFormatesGerbillinaeIon TransportMiceMutation, MissenseOxalatesPatch-Clamp TechniquesSalicylatesSulfate TransportersConceptsClosest phylogenetic relativesTransmembrane regionSLC26 anion transporter familyMammalian outer hair cellsMembrane protein prestinPrestin's motor functionAnion transportPhylogenetic relativesAnion transporter familyTransporter familyProtein prestinChloride-binding siteGating charge movementPrestinCharge movementHair cellsOuter hair cellsResiduesMechanistic conceptsVoltage sensingTransport capabilityCellsVoltage sensorPrevious observationsUptake studies
2006
The life-extending gene Indy encodes an exchanger for Krebs-cycle intermediates
Knauf F, Mohebbi N, Teichert C, Herold D, Rogina B, Helfand S, Gollasch M, Luft FC, Aronson PS. The life-extending gene Indy encodes an exchanger for Krebs-cycle intermediates. Biochemical Journal 2006, 397: 25-29. PMID: 16608441, PMCID: PMC1479758, DOI: 10.1042/bj20060409.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAgingAnimalsAntiportersCarbon RadioisotopesCell MembraneCitric AcidCitric Acid CycleDicarboxylic Acid TransportersDNA, ComplementaryDrosophilaDrosophila ProteinsHydrogen-Ion ConcentrationOocytesSodiumSuccinic AcidSymportersXenopusConceptsExternal citrateKrebs cycle intermediatesXenopus oocytesSodium dicarboxylate cotransporterMammalian genesDrosophila melanogasterIndy mutantsLifespan extensionLongevity genesPlasma membraneSubstrate effluxExternal mediumSpecific transport mechanismsFunctional studiesSuccinate uptakeAddition of succinateEnergy metabolismIndyTransportable substratesGenesOocytesEffluxMelanogasterMutantsSuccinate
2002
Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy
Knauf F, Rogina B, Jiang Z, Aronson PS, Helfand SL. Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 14315-14319. PMID: 12391301, PMCID: PMC137881, DOI: 10.1073/pnas.222531899.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAmino Acid SequenceAnimalsBiological TransportCationsCell MembraneCitratesCitric Acid CycleDicarboxylic Acid TransportersDrosophila ProteinsFurosemideGenes, InsectMolecular Sequence DataMutagenesisPhloretinSuccinic AcidSymportersXenopusConceptsPlasma membraneLife-extending mutationsNew longevity genesIntermediary metabolismAdult fat bodyIndy expressionCitric acid cycleLife-extending effectsMetabolite transportersVariety of speciesLongevity genesFunctional characterizationLife spanMidgut cellsFat bodyAcid cycleFunctional studiesXenopus oocytesTransport functionIndyBasolateral regionSodium-independent mechanismProminent expressionAverage life spanTransporters
2001
Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells
Knauf F, Yang C, Thomson R, Mentone S, Giebisch G, Aronson P. Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 9425-9430. PMID: 11459928, PMCID: PMC55437, DOI: 10.1073/pnas.141241098.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAmino Acid SequenceAnimalsAntiportersBase SequenceCloning, MolecularCOS CellsDNA PrimersDNA, ComplementaryFemaleKidney Tubules, ProximalMiceMice, Inbred C57BLMicroscopy, FluorescenceMicrovilliMolecular Sequence DataSodium-Phosphate Cotransporter Proteins, Type IIaXenopus laevis
1996
Mechanism of H(+)-coupled formate transport in rabbit renal microvillus membranes
Saleh AM, Rudnick H, Aronson PS. Mechanism of H(+)-coupled formate transport in rabbit renal microvillus membranes. American Journal Of Physiology 1996, 271: f401-f407. PMID: 8770172, DOI: 10.1152/ajprenal.1996.271.2.f401.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnimalsBiological TransportFormatesHydrogenHydrogen-Ion ConcentrationKidneyMaleMicrovilliRabbitsConceptsNonionic diffusionPathways for Oxalate Transport in Rabbit Renal Microvillus Membrane Vesicles*
Kuo S, Aronson P. Pathways for Oxalate Transport in Rabbit Renal Microvillus Membrane Vesicles*. Journal Of Biological Chemistry 1996, 271: 15491-15497. PMID: 8663096, DOI: 10.1074/jbc.271.26.15491.Peer-Reviewed Original Research4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnimalsAnionsBiological TransportChloridesFurosemideHydrogen-Ion ConcentrationKidney CortexKidney Tubules, ProximalMaleMembrane PotentialsMicrovilliOxalatesRabbitsSodiumSulfates
1993
Effects of formate and oxalate on chloride absorption in rat distal tubule
Wang T, Agulian SK, Giebisch G, Aronson PS. Effects of formate and oxalate on chloride absorption in rat distal tubule. American Journal Of Physiology 1993, 264: f730-f736. PMID: 8386473, DOI: 10.1152/ajprenal.1993.264.4.f730.Peer-Reviewed Original Research
1992
Effects of formate and oxalate on volume absorption in rat proximal tubule
Wang T, Giebisch G, Aronson PS. Effects of formate and oxalate on volume absorption in rat proximal tubule. American Journal Of Physiology 1992, 263: f37-f42. PMID: 1636743, DOI: 10.1152/ajprenal.1992.263.1.f37.Peer-Reviewed Original ResearchMeSH Keywords4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAbsorptionAnimalsChloridesFormatesIon ExchangeKidney Tubules, ProximalMaleOrtho-AminobenzoatesOxalatesPerfusionRatsRats, Inbred StrainsSodium ChlorideConceptsLuminal perfusateProximal tubulesCapillary perfusateLate proximal tubuleRat proximal tubuleHCO3- Ringer's solutionPhysiological rangePeritubular capillariesChannel blockersStandard Ringer solutionPerfusateFluid absorptionStimulatory effectNaCl absorptionRinger's solutionTubulesEffect of formateBlockers
1991
Cation specificity and modes of the Na+:CO3(2-):HCO3- cotransporter in renal basolateral membrane vesicles
Soleimani M, Lesoine GA, Bergman JA, Aronson PS. Cation specificity and modes of the Na+:CO3(2-):HCO3- cotransporter in renal basolateral membrane vesicles. Journal Of Biological Chemistry 1991, 266: 8706-8710. PMID: 2026588, DOI: 10.1016/s0021-9258(18)31503-5.Peer-Reviewed Original Research
1990
Rabbit ileal brush-border membrane Cl-HCO3 exchanger is activated by an internal pH-sensitive modifier site
Mugharbil A, Knickelbein RG, Aronson PS, Dobbins JW. Rabbit ileal brush-border membrane Cl-HCO3 exchanger is activated by an internal pH-sensitive modifier site. American Journal Of Physiology 1990, 259: g666-g670. PMID: 2171352, DOI: 10.1152/ajpgi.1990.259.4.g666.Peer-Reviewed Original Research
1989
Ionic mechanism of Na+-HCO3 − cotransport in rabbit renal basolateral membrane vesicles*
Soleimani M, Aronson PS. Ionic mechanism of Na+-HCO3 − cotransport in rabbit renal basolateral membrane vesicles*. Journal Of Biological Chemistry 1989, 264: 18302-18308. PMID: 2509453, DOI: 10.1016/s0021-9258(18)51463-0.Peer-Reviewed Original Research4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnimalsAnionsBicarbonatesBinding, CompetitiveBiological TransportCarbon DioxideCarrier ProteinsCell MembraneHydrogen-Ion ConcentrationKidneyLithiumMaleRabbitsSodiumSodium-Bicarbonate SymportersStilbenesSulfitesEffects of acetazolamide on Na+-HCO-3 cotransport in basolateral membrane vesicles isolated from rabbit renal cortex.
Soleimani M, Aronson PS. Effects of acetazolamide on Na+-HCO-3 cotransport in basolateral membrane vesicles isolated from rabbit renal cortex. Journal Of Clinical Investigation 1989, 83: 945-951. PMID: 2921327, PMCID: PMC303770, DOI: 10.1172/jci113980.Peer-Reviewed Original ResearchMeSH Keywords4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAcetatesAcetazolamideAmmoniaAnimalsBicarbonatesBiological TransportCarrier ProteinsCell MembraneHydrogen-Ion ConcentrationKidney CortexMaleRabbitsSodiumSodium-Bicarbonate Symporters
1988
Oxalate transport via the sulfate/HCO3 exchanger in rabbit renal basolateral membrane vesicles.
Kuo SM, Aronson PS. Oxalate transport via the sulfate/HCO3 exchanger in rabbit renal basolateral membrane vesicles. Journal Of Biological Chemistry 1988, 263: 9710-9717. PMID: 3384817, DOI: 10.1016/s0021-9258(19)81576-4.Peer-Reviewed Original Research4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnimalsAnion Transport ProteinsAntiportersBicarbonatesBiological TransportCarrier ProteinsCell MembraneChloridesElectrochemistryHydrogen-Ion ConcentrationKidney CortexKineticsLactatesLactic AcidMaleMembrane PotentialsOxalatesOxalic AcidPotassiumRabbitsSulfate TransportersSulfatesValinomycin
1987
Anion exchange pathways for Cl- transport in rabbit renal microvillus membranes
Karniski LP, Aronson PS. Anion exchange pathways for Cl- transport in rabbit renal microvillus membranes. American Journal Of Physiology 1987, 253: f513-f521. PMID: 3631282, DOI: 10.1152/ajprenal.1987.253.3.f513.Peer-Reviewed Original Research4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnimalsAnionsBiological TransportCell-Free SystemChloridesFormatesFurosemideKidney CortexMicrovilliOxalatesRabbitsEffect of formate on volume reabsorption in the rabbit proximal tubule.
Schild L, Giebisch G, Karniski LP, Aronson PS. Effect of formate on volume reabsorption in the rabbit proximal tubule. Journal Of Clinical Investigation 1987, 79: 32-38. PMID: 3793930, PMCID: PMC423979, DOI: 10.1172/jci112803.Peer-Reviewed Original ResearchMeSH Keywords4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnimalsFormatesHydrogen-Ion ConcentrationIn Vitro TechniquesKidney Tubules, ProximalOuabainRabbitsSodium ChlorideWater-Electrolyte BalanceConceptsProximal tubulesChloride/formate exchangeRabbit proximal tubuleNaCl reabsorptionProximal tubule S2 segmentsVolume reabsorptionElectroneutral NaCl reabsorptionNonionic diffusionFormate exchangeRabbit kidney cortexTransepithelial potential differenceActive NaCl reabsorptionKidney cortexChloride absorptionTubule fluidS2 segmentsReabsorptionGlass pH microelectrodesTubulesEffect of formateMicrovillus membranePerfusateCortex
1986
Na-H exchange in rat liver basolateral but not canalicular plasma membrane vesicles
Moseley RH, Meier PJ, Aronson PS, Boyer JL. Na-H exchange in rat liver basolateral but not canalicular plasma membrane vesicles. American Journal Of Physiology 1986, 250: g35-g43. PMID: 3002192, DOI: 10.1152/ajpgi.1986.250.1.g35.Peer-Reviewed Original ResearchMeSH Keywords4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAcridine OrangeAmilorideAmmoniaAnimalsBasement MembraneBiological Transport, ActiveCarrier ProteinsCell MembraneFiltrationHydrogen-Ion ConcentrationLithiumLiverMaleMembrane PotentialsOsmolar ConcentrationPotassiumRatsRats, Inbred StrainsSodiumSodium-Hydrogen ExchangersValinomycin
1985
Effects of cations on pH gradient-stimulated sulfate transport in rabbit ileal brush-border membrane vesicles
Schron CM, Knickelbein RG, Aronson PS, Della Puca J, Dobbins JW. Effects of cations on pH gradient-stimulated sulfate transport in rabbit ileal brush-border membrane vesicles. American Journal Of Physiology 1985, 249: g614-g621. PMID: 4061649, DOI: 10.1152/ajpgi.1985.249.5.g614.Peer-Reviewed Original ResearchMeSH Keywords4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnimalsBiological TransportCations, MonovalentDose-Response Relationship, DrugHydrogen-Ion ConcentrationIleumIon ExchangeMaleMicrovilliPotassiumRabbitsSodiumStimulation, ChemicalSulfatesSodium and chloride transport across rabbit ileal brush border. II. Evidence for Cl-HCO3 exchange and mechanism of coupling
Knickelbein R, Aronson PS, Schron CM, Seifter J, Dobbins JW. Sodium and chloride transport across rabbit ileal brush border. II. Evidence for Cl-HCO3 exchange and mechanism of coupling. American Journal Of Physiology 1985, 249: g236-g245. PMID: 3927745, DOI: 10.1152/ajpgi.1985.249.2.g236.Peer-Reviewed Original ResearchMeSH Keywords4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAmilorideAnimalsAnionsBicarbonatesCarbonic AnhydrasesChloridesHydrogen-Ion ConcentrationHydroxidesIleumIn Vitro TechniquesIntestinal AbsorptionIntestinal MucosaMembrane PotentialsMicrovilliModels, BiologicalPotassiumRabbitsSodiumConceptsStimulation of ClBrush border membraneCl- uptakeInside-alkaline pH gradientCl transportCl-HCO3 exchangeRabbit ileumCoupling of NaX minMM ClBrush border vesiclesBrush borderN2-5Saturable functionMM KClNa uptakeLevel fourfoldAddition of HCO3K diffusion potentialsCarbonic anhydrase activityChloride transportUptake
1984
Absence of Cl-OH exchange and NaCl cotransport in rabbit renal microvillus membrane vesicles
Seifter JL, Knickelbein R, Aronson PS. Absence of Cl-OH exchange and NaCl cotransport in rabbit renal microvillus membrane vesicles. American Journal Of Physiology 1984, 247: f753-f759. PMID: 6093589, DOI: 10.1152/ajprenal.1984.247.5.f753.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic AcidAcid-Base EquilibriumAcridine OrangeAnimalsBicarbonatesChloridesHydrogen-Ion ConcentrationIon ChannelsKidney CortexMicrovilliRabbitsSodium ChlorideValinomycin