1998
An Alternate Promoter Directs Expression of a Truncated, Muscle-specific Isoform of the Human Ankyrin 1 Gene*
Gallagher P, Forget B. An Alternate Promoter Directs Expression of a Truncated, Muscle-specific Isoform of the Human Ankyrin 1 Gene*. Journal Of Biological Chemistry 1998, 273: 1339-1348. PMID: 9430667, DOI: 10.1074/jbc.273.3.1339.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingAmino Acid SequenceAnkyrinsBase SequenceCloning, MolecularDNA, ComplementaryErythroid Precursor CellsExonsGene Expression RegulationHumansMolecular Sequence DataMuscle, SkeletalMusclesMyocardiumMyoD ProteinPromoter Regions, GeneticRecombinant ProteinsTranscriptional ActivationConceptsKilobase pairsMuscle cDNADeduced amino acid sequenceCorresponding chromosomal geneHydrophobic NH2 terminusCultured C2C12 muscle cellsHuman ankyrin-1 geneSkeletal muscle cDNADNA-protein interactionsE-box consensusAmino acid sequenceK562 cellsMuscle-specific isoformPromoter directs expressionC2C12 muscle cellsAnkyrin-1 geneReporter gene plasmidHigh-level expressionNorthern blot analysisErythroid genesErythrocyte membrane proteinsSingle Sp1Erythroid promoterAlternative splicingRich promoter
1997
Structure and Organization of the Human Ankyrin-1 Gene BASIS FOR COMPLEXITY OF PRE-mRNA PROCESSING*
Gallagher P, Tse W, Scarpa A, Lux S, Forget B. Structure and Organization of the Human Ankyrin-1 Gene BASIS FOR COMPLEXITY OF PRE-mRNA PROCESSING*. Journal Of Biological Chemistry 1997, 272: 19220-19228. PMID: 9235914, DOI: 10.1074/jbc.272.31.19220.Peer-Reviewed Original ResearchConceptsGenomic structureANK-1 geneSpectrin-binding domainMembrane-binding domainIntron/exon boundariesAlternative polyadenylation signalsPre-mRNA processingBrain-specific transcriptFurther genetic studiesErythrocyte membrane proteinsErythroid transcriptsCommon hemolytic anemiaGene basisAlternative splicingRegulatory domainProtein domainsChromosomal genesMembrane proteinsKilobase pairsPolyadenylation signalMembrane skeletonPlasma membraneExon boundariesGenetic studiesAnkyrin 1