2001
Programmed Cell Death of Developing Mammalian Neurons after Genetic Deletion of Caspases
Oppenheim R, Flavell R, Vinsant S, Prevette D, Kuan C, Rakic P. Programmed Cell Death of Developing Mammalian Neurons after Genetic Deletion of Caspases. Journal Of Neuroscience 2001, 21: 4752-4760. PMID: 11425902, PMCID: PMC6762357, DOI: 10.1523/jneurosci.21-13-04752.2001.Peer-Reviewed Original ResearchConceptsCell deathGenetic deletionExtensive cytoplasmic vacuolizationPro-apoptotic proteasesCaspase familySpecific caspasesChromatin condensationNonapoptotic pathwaysPostmitotic neuronsCaspase-9Mammalian neuronsCell typesDeath processSpecific perturbationsCaspase-3Altered morphologyCaspasesNuclear changesKey membersDeletionUTP nickCytoplasmic vacuolizationElectron microscopic levelTerminal deoxynucleotidyl transferase-mediated biotinylated UTP nickNeuronal populationsThe generation, migration, and differentiation of olfactory neurons in the adult primate brain
Kornack D, Rakic P. The generation, migration, and differentiation of olfactory neurons in the adult primate brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 4752-4757. PMID: 11296302, PMCID: PMC31906, DOI: 10.1073/pnas.081074998.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCell DifferentiationCell MovementImmunohistochemistryMacaca fascicularisMacaca mulattaNeuronsOlfactory PathwaysPhenotypePrimatesConceptsRostral migratory streamOlfactory bulbAdult primate brainAdult macaque monkeysNeural progenitor cellsSmaller olfactory bulbsAdult rodentsSubependymal zoneImmunohistochemical detectionPrimate brainMacaque monkeysOlfactory neuronsMigratory streamNonhuman primatesProgenitor cellsRegenerative mechanismsInterneuronsHuman brainBrainNeuroblastsCellsNeuronsBcl-XL–Caspase-9 Interactions in the Developing Nervous System: Evidence for Multiple Death Pathways
Zaidi A, D'Sa-Eipper C, Brenner J, Kuida K, Zheng T, Flavell R, Rakic P, Roth K. Bcl-XL–Caspase-9 Interactions in the Developing Nervous System: Evidence for Multiple Death Pathways. Journal Of Neuroscience 2001, 21: 169-175. PMID: 11150333, PMCID: PMC6762421, DOI: 10.1523/jneurosci.21-01-00169.2001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBcl-2-Associated X ProteinBcl-X ProteinCaspase 3Caspase 9CaspasesCells, CulturedCytarabineGanglia, SpinalGenes, LethalHeterozygoteHomozygoteImmunohistochemistryIn Situ Nick-End LabelingLiverMiceMice, KnockoutNervous SystemNeuronsProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2TelencephalonTumor Suppressor Protein p53ConceptsGene family membersCaspase-9 deficiencyCaspase-9Telencephalic neural precursor cellsCell deathDouble homozygous mutantsCaspase family membersMultiple death pathwaysNormal nervous system developmentBcl-2Nervous system developmentBax-deficient neuronsNeuronal apoptosisTelencephalic neuronsDeficient embryosNeural precursor cellsDeath pathwaysFamily membersHomozygous mutantsApoptotic pathwayObligate pathwayBcl-xLApoptosis inducersDeficient neuronsTargeted disruption
2000
Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain
Laywell E, Rakic P, Kukekov V, Holland E, Steindler D. Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 13883-13888. PMID: 11095732, PMCID: PMC17670, DOI: 10.1073/pnas.250471697.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesBrainCell LineageGlial Fibrillary Acidic ProteinImmunohistochemistryMiceMicroscopy, ElectronStem CellsConceptsCentral nervous systemNeural stem cellsAstrocyte monolayersMultipotent astrocytic stem cellsAstrocytic stem cellsPostnatal central nervous systemAdult mouse brainStem cellsCerebral cortexPostnatal wkSpinal cordAdult brainSubependymal zoneNervous systemEpendymal cellsMouse brainMammalian brainSpherical clonesCNS developmentBrainVivo identificationAstrocytesMature forebrainCritical periodCE cells
1999
Continuation of neurogenesis in the hippocampus of the adult macaque monkey
Kornack D, Rakic P. Continuation of neurogenesis in the hippocampus of the adult macaque monkey. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 5768-5773. PMID: 10318959, PMCID: PMC21935, DOI: 10.1073/pnas.96.10.5768.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesBiological EvolutionBromodeoxyuridineCercopithecidaeDentate GyrusHippocampusImmunohistochemistryMacacaNeuronsOligodendrogliaPhylogenyConceptsAdult macaque monkeysDentate gyrusMacaque monkeysAdult primate hippocampusAdult rodent dentate gyrusImmunohistochemical double labelingHippocampal dentate gyrusRodent dentate gyrusDiscreet brain regionsMultipotent neural stem cellsNeural stem cellsAdult neurogenesisAdult brainPrimate hippocampusAnimal modelsBrain regionsDouble labelingNeurogenesisSpecific markersHippocampusGyrusStem cellsCell typesMonkeysHumans
1998
Peptidergic innervation and the nicotinic acetylcholine receptor in the primate basal nucleus
Csillik B, Rakic P, Knyihár‐Csillik E. Peptidergic innervation and the nicotinic acetylcholine receptor in the primate basal nucleus. European Journal Of Neuroscience 1998, 10: 573-585. PMID: 9749720, DOI: 10.1046/j.1460-9568.1998.00066.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasal GangliaCalcitonin Gene-Related PeptideFemaleImmunohistochemistryMacaca fascicularisMaleNeuropeptidesReceptors, NicotinicConceptsCalcitonin gene-related peptidePrincipal nerve cellsNeuropeptide YNicotinic acetylcholine receptorsSubstance PBasal nucleusAcetylcholine receptorsPeptidergic innervationBasal forebrainPrincipal cellsElectron microscopic pre-embedding immunocytochemistryAlpha-BTXNerve cellsNeuronal nicotinic acetylcholine receptorsMeynert's basal nucleusCholine acetyltransferase immunoreactivityGene-related peptideImmunohistochemical double stainingPre-embedding immunocytochemistryImmunopositive axonsPresynaptic nAChRsCGRP immunoreactivityAcetylcholine releaseNeuronal nAChRsGlomerular arrangement
1997
Early emergence of photoreceptor mosaicism in the primate retina revealed by a novel cone‐specific monoclonal antibody
Wikler K, Rakic P, Bhattacharyya N, Macleish P. Early emergence of photoreceptor mosaicism in the primate retina revealed by a novel cone‐specific monoclonal antibody. The Journal Of Comparative Neurology 1997, 377: 500-508. PMID: 9007188, DOI: 10.1002/(sici)1096-9861(19970127)377:4<500::aid-cne2>3.0.co;2-6.Peer-Reviewed Original ResearchConceptsPrimate retinaFetal retinaMonoclonal antibodiesAdult primate retinaEmbryonic day 80Opsin-positive conesOuter plexiform layerNovel monoclonal antibodyPopulation of conesShort-wavelength sensitive conesDouble-labeling experimentsSynaptic contactsPlexiform layerPhotoreceptor layerWavelength-sensitive conesMacaque monkeysSynaptic connectionsFetal ageRetinaDay 80Cone genesisCone opsinsImmunoreactivityAntibodiesInitial differentiation
1996
Selective expression of m2 muscarinic receptor in the parvocellular channel of the primate visual cortex.
Mrzljak L, Levey A, Rakic P. Selective expression of m2 muscarinic receptor in the parvocellular channel of the primate visual cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 7337-7340. PMID: 8692994, PMCID: PMC38985, DOI: 10.1073/pnas.93.14.7337.Peer-Reviewed Original ResearchConceptsDorsal lateral geniculate nucleusLateral geniculate nucleusGeniculate nucleusVisual cortexMacaque monkey visual cortexM2 muscarinic acetylcholine receptorM2 muscarinic receptorsM2 receptor proteinMuscarinic acetylcholine receptorsMonkey visual cortexPrimate visual cortexM2 receptorsCerebral cortexMuscarinic receptorsExcitatory neurotransmissionParvocellular layersLayers IIAcetylcholine receptorsSynaptic circuitsNeuronal channelsParvocellular channelsParvocellular pathwayCortexSelective expressionReceptorsRole of neuron-glial junctional domain proteins in the maintenance and termination of neuronal migration across the embryonic cerebral wall
Anton E, Cameron R, Rakic P. Role of neuron-glial junctional domain proteins in the maintenance and termination of neuronal migration across the embryonic cerebral wall. Journal Of Neuroscience 1996, 16: 2283-2293. PMID: 8601808, PMCID: PMC6578523, DOI: 10.1523/jneurosci.16-07-02283.1996.Peer-Reviewed Original ResearchConceptsEmbryonic cerebral wallCerebral wallNeuronal migrationCerebral cortexNeuronal migratory pathwayRadial glial cell processesRadial glial fibersGlial cell processesNormal neuronal migrationCortical plateSlice preparationAntibody exposureGlial fibersMarginal zone regionsMonoclonal antibodiesAntibodiesNeuronsCortexCell substratesMarginal zonePolyclonal antiserumMicrotubular organizationCell processesMigratory pathwaysCell detachment
1994
An array of early differentiating cones precedes the emergence of the photoreceptor mosaic in the fetal monkey retina.
Wikler K, Rakic P. An array of early differentiating cones precedes the emergence of the photoreceptor mosaic in the fetal monkey retina. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 6534-6538. PMID: 7912829, PMCID: PMC44237, DOI: 10.1073/pnas.91.14.6534.Peer-Reviewed Original ResearchConceptsFetal monkey retinaMonkey retinaRetinal ganglion cellsSubset of conesRed/green opsinImportant developmental markersGanglion cellsPrimate retinaGreen-sensitive conesDistinct antigensPhotoreceptor phenotypeRetinaMonoclonal antibodiesPhotoreceptor mosaicCone differentiationDevelopmental markersAntibodiesImmature regionsSame patternGreen opsinsAntigenSynaptogenesisSubset
1993
Low-affinity p75 nerve growth factor receptor expression in the embryonic monkey telencephalon: Timing and localization in diverse cellular elements
Meinecke D, Rakic P. Low-affinity p75 nerve growth factor receptor expression in the embryonic monkey telencephalon: Timing and localization in diverse cellular elements. Neuroscience 1993, 54: 105-116. PMID: 8515837, DOI: 10.1016/0306-4522(93)90386-t.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEmbryo, MammalianImmunohistochemistryMacaca mulattaNerve FibersReceptors, Nerve Growth FactorTelencephalonTime FactorsTissue DistributionConceptsDiverse cellular elementsNerve growth factor receptorGrowth factor receptorCerebral cortexCellular elementsFactor receptorAxonal processesNerve growth factor receptor expressionLow-affinity nerve growth factor receptorGrowth factorEmbryonic day 45Transient subplate neuronsGrowth factor receptor expressionFactor receptor expressionOnset of neurogenesisNerve growth factorHuman nerve growth factor receptorGrowth factor familyMonkey telencephalonSubplate neuronsSubplate zoneReceptor expressionFetal brainActive neurogenesisNeuronal proliferation
1992
Immunocytochemical localization of DARPP‐32, a dopamine and cyclic‐ AMP‐regulated phosphoprotein, in the primate brain
Ouimet C, Lamantia A, Goldman‐Rakic P, Rakic P, Greengard P. Immunocytochemical localization of DARPP‐32, a dopamine and cyclic‐ AMP‐regulated phosphoprotein, in the primate brain. The Journal Of Comparative Neurology 1992, 323: 209-218. PMID: 1328330, DOI: 10.1002/cne.903230206.Peer-Reviewed Original ResearchConceptsDARPP-32Axon terminalsCaudate nucleusDARPP-32-positive neuronsSubstantia nigra pars reticulataAnterior olfactory areaMajority of somataSubcortical white matterUnlabeled axon terminalsAction of dopamineVentral tegmental areaDARPP-32 immunoreactivityCerebral cortexPars reticulataDopaminergic neuronsImmunoreactive somataSubstantia nigraArcuate nucleusGlobus pallidusTegmental areaMedial habenulaDopamine receptorsOlfactory areasVentral pallidumBed nucleusExpression of GABA and GABAa receptors by neurons of the subplate zone in developing primate occipital cortex: Evidence for transient local circuits
Meinecke D, Rakic P. Expression of GABA and GABAa receptors by neurons of the subplate zone in developing primate occipital cortex: Evidence for transient local circuits. The Journal Of Comparative Neurology 1992, 317: 91-101. PMID: 1315345, DOI: 10.1002/cne.903170107.Peer-Reviewed Original ResearchConceptsSubplate zoneExpression of GABASitu hybridizationGABAA receptorsTrophic interactionsPlasma membraneGABAA/benzodiazepine receptor complexGABAA receptor subunit mRNAsMammalian telencephalonUnlabeled axon terminalsTransient subplate zoneGABAA receptor subunitsLines of evidenceLocal neuronal circuitsBenzodiazepine receptor complexReceptor subunit mRNAsHybridization signalsReceptor complexSubunitsReceptor moleculesReceptor subunitsSubplate neuronsCortical afferentsSymmetrical synapsesEmbryonic day
1990
Distribution of photoreceptor subtypes in the retina of diurnal and nocturnal primates
Wikler K, Rakic P. Distribution of photoreceptor subtypes in the retina of diurnal and nocturnal primates. Journal Of Neuroscience 1990, 10: 3390-3401. PMID: 2145402, PMCID: PMC6570186, DOI: 10.1523/jneurosci.10-10-03390.1990.Peer-Reviewed Original ResearchConceptsRhesus monkey retinaMonkey retinaRhesus monkeysNew World owl monkeysOwl monkeysCone inner segmentsAbnormal colour visionBlue cone opsinDensity of conesColor visionBlue-sensitive conesDorsal retinaGreen cone opsinRetinaSpecific antibodiesCSA-1Inner segmentsMonkeysFoveaAntibodiesPhotoreceptor subtypesRed/greenDevelopmental expression of GABA and subunits of the GABAA receptor complex in an inhibitory synaptic circuit in the rat cerebellum
Meinecke D, Rakic P. Developmental expression of GABA and subunits of the GABAA receptor complex in an inhibitory synaptic circuit in the rat cerebellum. Brain Research 1990, 55: 73-86. PMID: 2170058, DOI: 10.1016/0165-3806(90)90107-a.Peer-Reviewed Original ResearchConceptsGABAA receptor subunitsGranule cellsSynaptic circuitsGABAA receptorsPresynaptic elementsReceptor labelingReceptor subunitsGABAA/benzodiazepine receptor complexGolgi II neuronsInhibitory synaptic circuitsSpecific synaptic circuitsGranular layerInhibitory transmitter GABAFifth postnatal dayGABAA receptor complexCentral nervous systemCerebellum of ratsBenzodiazepine receptor complexMature granule cellsReceptor complexPresence of GABAInternal granular layerAlpha 1 subunitGABA transmittersGABAergic afferents
1989
GABAA/benzodiazepine receptor-like immunoreactivity in rat and monkey cerebellum
Meinecke D, Tallman J, Rakic P. GABAA/benzodiazepine receptor-like immunoreactivity in rat and monkey cerebellum. Brain Research 1989, 493: 303-319. PMID: 2548668, DOI: 10.1016/0006-8993(89)91165-7.Peer-Reviewed Original ResearchConceptsReceptor-like immunoreactivityGABAA/benzodiazepine receptorGolgi type II cellsType II cellsAxon terminalsBasket cellsBenzodiazepine receptorsCerebellar cortexCortical layersII cellsMonkey cerebellumUnlabeled axon terminalsCytoplasm of neuronsMossy fiber terminalsDeep cerebellar nucleiImmunoreactive dendritesSymmetric synapsesImmunostained neuronsInhibitory circuitsLabel neuronsGlial cellsNeuronal typesFiber terminalsGranule cellsStellate cellsMultiple types of neuropeptide Y‐containing neurons in primate neocortex
Kuljis R, Rakic P. Multiple types of neuropeptide Y‐containing neurons in primate neocortex. The Journal Of Comparative Neurology 1989, 280: 393-409. PMID: 2918101, DOI: 10.1002/cne.902800306.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebral CortexImmunohistochemistryMacacaMacaca fascicularisMacaca mulattaNeuronsNeuropeptide YConceptsAspiny stellate cellsStellate cellsNeuropeptide YSmall local circuit neuronsNPY-containing neuronsAvidin-biotin-peroxidase methodLocal circuit neuronsSpiny stellate cellsAdult macaque monkeysLocal neuronal circuitsCircuit neuronsLayer IVAElectron microscopic levelMartinotti cellsSupragranular layersLayer VIMultipolar neuronsLayer IVNonneuronal elementsCortical greyLaminar locationSpinous dendritesNeuronal typesPattern of ramificationGranule cells
1988
Nature and fate of proliferative cells in the hippocampal dentate gyrus during the life span of the rhesus monkey
Eckenhoff M, Rakic P. Nature and fate of proliferative cells in the hippocampal dentate gyrus during the life span of the rhesus monkey. Journal Of Neuroscience 1988, 8: 2729-2747. PMID: 3411351, PMCID: PMC6569394, DOI: 10.1523/jneurosci.08-08-02729.1988.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAutoradiographyCell DivisionGlial Fibrillary Acidic ProteinHippocampusImmunohistochemistryMacacaMacaca mulattaMicroscopy, ElectronThymidineConceptsProliferative cellsMitotic divisionPostmitotic cellsUltra-structural characteristicsPossible functionsElectron microscopic levelStable populationGlial fibrillary acidic proteinNeuronal cellsStem cellsJuvenile periodMajor classesMature primatesSubgranular zoneDentate gyrusGlial cellsLife spanCellsGFAP-negative cellsFateRhesus monkeysAcidic proteinNew neuronsPostpubertal animalsFibrillary acidic proteinCCK-immunoreactive terminals form different types of synapses in the rat and monkey hippocampus
Leranth C, Frotscher M, Rakic P. CCK-immunoreactive terminals form different types of synapses in the rat and monkey hippocampus. Histochemistry And Cell Biology 1988, 88: 343-352. PMID: 3366638, DOI: 10.1007/bf00570293.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCholecystokininHippocampusImmunohistochemistryMacaca mulattaMaleMicroscopy, ElectronRatsSpecies SpecificitySynapsesConceptsSynaptic contactsMonkey hippocampusSymmetric synaptic contactsAsymmetric synaptic contactsDistribution of CCKExcitatory transmissionSymmetric synapsesDendritic shaftsPyramidal cellsRat hippocampusCA3 regionDendritic spinesPrimate hippocampusHippocampusCell bodiesRodent hippocampusSame neuropeptidesImmunocytochemical analysisPresent findingsRatsSynapsesImportant differencesAsymmetric contactsCholecystokininCA1