2014
Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia
Brennand K, Savas J, Kim Y, Tran N, Simone A, Hashimoto-Torii K, Beaumont K, Kim H, Topol A, Ladran I, Abdelrahim M, Matikainen-Ankney B, Chao S, Mrksich M, Rakic P, Fang G, Zhang B, Yates J, Gage F. Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia. Molecular Psychiatry 2014, 20: 361-368. PMID: 24686136, PMCID: PMC4182344, DOI: 10.1038/mp.2014.22.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntipsychotic AgentsCell DifferentiationCell MovementCells, CulturedFemaleGene ExpressionHumansMaleMiceMice, Inbred C57BLMice, TransgenicMitochondriaNeural Cell Adhesion MoleculesNeural Stem CellsOxidative StressPhenotypePluripotent Stem CellsProsencephalonProteomicsReactive Oxygen SpeciesSchizophreniaYoung AdultConceptsHiPSC neural progenitor cellsNeural progenitor cellsHuman-induced pluripotent stem cellsHiPSC-derived neuronsGene expressionGene expression comparisonsStable isotope labelingProteomic mass spectrometry analysisAbnormal gene expressionPluripotent stem cellsOxidative stressCytoskeletal remodelingMass spectrometry analysisCellular phenotypesExpression comparisonsDevelopmental mechanismsIsotope labelingPhenotypic differencesBrainSpan AtlasDisease predispositionAmino acidsScalable assayNPC phenotypeStem cellsProgenitor cells
2010
Gap Junctions/Hemichannels Modulate Interkinetic Nuclear Migration in the Forebrain Precursors
Liu X, Hashimoto-Torii K, Torii M, Ding C, Rakic P. Gap Junctions/Hemichannels Modulate Interkinetic Nuclear Migration in the Forebrain Precursors. Journal Of Neuroscience 2010, 30: 4197-4209. PMID: 20335455, PMCID: PMC2861434, DOI: 10.1523/jneurosci.4187-09.2010.Peer-Reviewed Original Research4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAdenosine TriphosphateAnimalsBoron CompoundsBromodeoxyuridineCalciumCalcium SignalingCarbenoxoloneCell Line, TumorCell MovementCell NucleusCerebral VentriclesChelating AgentsConnexin 43Cyclooxygenase InhibitorsEgtazic AcidEmbryo, MammalianFemaleGap JunctionsGreen Fluorescent ProteinsKi-67 AntigenMeclofenamic AcidMiceNeuroblastomaNeuronsOrgan Culture TechniquesPatch-Clamp TechniquesPlatelet Aggregation InhibitorsPregnancyProsencephalonPyridoxal PhosphateStem Cells
2001
Programmed Cell Death of Developing Mammalian Neurons after Genetic Deletion of Caspases
Oppenheim R, Flavell R, Vinsant S, Prevette D, Kuan C, Rakic P. Programmed Cell Death of Developing Mammalian Neurons after Genetic Deletion of Caspases. Journal Of Neuroscience 2001, 21: 4752-4760. PMID: 11425902, PMCID: PMC6762357, DOI: 10.1523/jneurosci.21-13-04752.2001.Peer-Reviewed Original ResearchConceptsCell deathGenetic deletionExtensive cytoplasmic vacuolizationPro-apoptotic proteasesCaspase familySpecific caspasesChromatin condensationNonapoptotic pathwaysPostmitotic neuronsCaspase-9Mammalian neuronsCell typesDeath processSpecific perturbationsCaspase-3Altered morphologyCaspasesNuclear changesKey membersDeletionUTP nickCytoplasmic vacuolizationElectron microscopic levelTerminal deoxynucleotidyl transferase-mediated biotinylated UTP nickNeuronal populations
1999
Molecular Gradients and Compartments in the Embryonic Primate Cerebral Cortex
Donoghue M, Rakic P. Molecular Gradients and Compartments in the Embryonic Primate Cerebral Cortex. Cerebral Cortex 1999, 9: 586-600. PMID: 10498277, DOI: 10.1093/cercor/9.6.586.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntisense Elements (Genetics)Brain ChemistryCloning, MolecularDNA-Binding ProteinsEphrin-A1FemaleGene Expression Regulation, DevelopmentalGene Expression Regulation, EnzymologicHomeodomain ProteinsIn Situ HybridizationMacaca mulattaNeocortexNeuronsPregnancyProsencephalonProteinsReceptor Protein-Tyrosine KinasesTranscription FactorsConceptsCerebral cortexPrimate cerebral cortexEmbryonic cerebral cortexMature cerebral cortexEphA receptor tyrosine kinasesArrival of afferentsPrimate forebrainCortical plateMature cortexEfferent connectionsCortical developmentCortical areasAnteroposterior extentSpecific afferentsMacaque monkeysReceptor tyrosine kinasesPeripheral influencesCortexGene expressionPrimate corticogenesisAfferentsNeocortexIntrinsic programCorticogenesisTyrosine kinaseDiscriminating migrations
Rakic P. Discriminating migrations. Nature 1999, 400: 315-316. PMID: 10432106, DOI: 10.1038/22427.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChemotaxisDrosophila ProteinsMiceNerve Tissue ProteinsNeuronsOlfactory BulbProsencephalon