2000
Mechanisms of programmed cell death in the developing brain
Kuan C, Roth K, Flavell R, Rakic P, Kuan C, Roth K, Flavell R, Rakic P. Mechanisms of programmed cell death in the developing brain. Trends In Neurosciences 2000, 23: 291-297. PMID: 10856938, DOI: 10.1016/s0166-2236(00)01581-2.Peer-Reviewed Original ResearchConceptsCell deathNematode Caenorhabditis elegansEarly embryonic developmentGene-targeting studiesCell death pathwaysVertebrate nervous systemMammalian brain developmentCaenorhabditis elegansEmbryonic developmentGenetic analysisPostmitotic neuronsBrain developmentNeural cell deathAnalogous functionsDistinct rolesProgenitor cellsMammalian brainApoptosisNew insightsImportant mechanismElegansHomologLater stagesNervous systemMechanismProgrammed Cell Death in Mouse Brain Development
Kuan C, Flavell R, Rakic P. Programmed Cell Death in Mouse Brain Development. Results And Problems In Cell Differentiation 2000, 30: 145-162. PMID: 10857188, DOI: 10.1007/978-3-540-48002-0_6.Peer-Reviewed Original ResearchConceptsCell death machineryMouse brain developmentCell deathDeath machineryNematode Caenorhabditis elegansBasic cellular eventsIdeal experimental systemVertebrate nervous systemBrain developmentCaenorhabditis elegansNormal human brain developmentNerve growth factorGenetic pathwaysTrophic theoryRecent geneSpecific genesCellular eventsGenetic studiesNeural developmentHuman brain developmentTargeted disruptionHigher primatesMechanistic understandingEssential roleGenes
1996
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
Kuida K, Zheng T, Na S, Kuan C, Yang D, Karasuyama H, Rakic P, Flavell R. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 1996, 384: 368-372. PMID: 8934524, DOI: 10.1038/384368a0.Peer-Reviewed Original ResearchConceptsCED-3Protease familyMajor morphogenetic changesProgrammed Cell DeathICE protease familyMutant embryosCaenorhabditis elegansDeath genesMorphogenetic cellApoptotic stimuliHomologous recombinationMorphogenetic changesMendelian geneticsSequence homologyHigh similarityCell deathPremature lethalitySupernumerary cellsEmbryonic day 12Mammalian brainCPP32Critical rolePostnatal stagesApoptosisBrain development