2019
Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons
Stavoe A, Gopal P, Gubas A, Tooze S, Holzbaur E. Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons. ELife 2019, 8: e44219. PMID: 31309927, PMCID: PMC6634969, DOI: 10.7554/elife.44219.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisAged miceNovel therapeutic targetLate-onset neurodegenerative diseasesAge-associated neurodegenerationAge-related declineAged neuronsRisk factorsLateral sclerosisParkinson's diseaseTherapeutic targetLC3B-positive autophagosomesNeurodegenerative diseasesMammalian neuronsNeuronsSignificant decreaseDiseaseRate of autophagy
2014
MicroRNA-124 expression counteracts pro-survival stress responses in glioblastoma
Mucaj V, Lee S, Skuli N, Giannoukos D, Qiu B, Eisinger-Mathason T, Nakazawa M, Shay J, Gopal P, Venneti S, Lal P, Minn A, Simon M, Mathew L. MicroRNA-124 expression counteracts pro-survival stress responses in glioblastoma. Oncogene 2014, 34: 2204-2214. PMID: 24954504, PMCID: PMC4275412, DOI: 10.1038/onc.2014.168.Peer-Reviewed Original ResearchConceptsMiR-124 expressionMiR-124 levelsGlioblastoma patient samplesTumor cell survivalPatient samplesAggressive adult brain tumorCell survivalCell deathSurvival of miceAdult brain tumorsHypoxic gene signaturePoor patient outcomesIntracranial xenograft tumorsHypoxic cell deathIncreases cell deathPatient outcomesTumor ischemiaXenograft tumorsBrain tumorsGlioblastoma patientsIschemic regionTherapeutic resistanceTumor progressionCancer typesGene signature