2016
Optimal Computed Tomographic Perfusion Scan Duration for Assessment of Acute Stroke Lesion Volumes
Kasasbeh AS, Christensen S, Straka M, Mishra N, Mlynash M, Bammer R, Albers GW, Lansberg MG. Optimal Computed Tomographic Perfusion Scan Duration for Assessment of Acute Stroke Lesion Volumes. Stroke 2016, 47: 2966-2971. PMID: 27895299, PMCID: PMC5134896, DOI: 10.1161/strokeaha.116.014177.Peer-Reviewed Original ResearchMeSH KeywordsCerebrovascular CirculationHumansPerfusion ImagingRetrospective StudiesStrokeTime FactorsTomography, X-Ray ComputedConceptsVenous output functionOptimal scan timeLesion volumePerfusion scanAcute stroke patientsIschemic lesion volumeStroke lesion volumeScan durationLesion volume measurementsMost patientsStroke patientsTomographic perfusionOptimal durationScan protocolTotal scan durationContrast bolusScansScan timePatientsSufficient durationDurationVolume measurementsShort scan durationPerfusionBolusA benchmarking tool to evaluate computer tomography perfusion infarct core predictions against a DWI standard
Cereda CW, Christensen S, Campbell B, Mishra NK, Mlynash M, Levi C, Straka M, Wintermark M, Bammer R, Albers GW, Parsons MW, Lansberg MG. A benchmarking tool to evaluate computer tomography perfusion infarct core predictions against a DWI standard. Cerebrovascular And Brain Metabolism Reviews 2016, 36: 1780-1789. PMID: 26661203, PMCID: PMC5076783, DOI: 10.1177/0271678x15610586.Peer-Reviewed Original Research
2015
Response to endovascular reperfusion is not time-dependent in patients with salvageable tissue
Lansberg MG, Cereda CW, Mlynash M, Mishra NK, Inoue M, Kemp S, Christensen S, Straka M, Zaharchuk G, Marks MP, Bammer R, Albers GW, Saver J, Fayad P, Howard G, Tomsick. T, Jovin T, Wechsler L, DeCesare S, Thai D, Sherr A, Wilder M, Tricot A, Lutsep H, McDaneld L, Larsen D, Czartoski T, Keogh B, Malik A, Brown A, Bernstein R, Muskovich K, Chang C, Stern T, Warach S, Davis L, Fazekas F, Seifert-Held T. Response to endovascular reperfusion is not time-dependent in patients with salvageable tissue. Neurology 2015, 85: 708-714. PMID: 26224727, PMCID: PMC4553034, DOI: 10.1212/wnl.0000000000001853.Peer-Reviewed Original ResearchConceptsGood functional outcomeEndovascular reperfusionFunctional outcomeSalvageable tissueLesion volumeLesion growthRandomized placebo-controlled trialModified Rankin Scale scorePerfusion Imaging EvaluationPerfusion lesion volumeTarget mismatch profilePlacebo-controlled trialRankin Scale scorePerfusion-diffusion mismatchSubgroup of patientsRadiologic outcomesCohort studyEndovascular therapyEarly followStroke patientsImaging evaluationReperfusionDay 90PatientsScale scoreReperfusion of Very Low Cerebral Blood Volume Lesion Predicts Parenchymal Hematoma After Endovascular Therapy
Mishra NK, Christensen S, Wouters A, Campbell BC, Straka M, Mlynash M, Kemp S, Cereda CW, Bammer R, Marks MP, Albers GW, Lansberg MG. Reperfusion of Very Low Cerebral Blood Volume Lesion Predicts Parenchymal Hematoma After Endovascular Therapy. Stroke 2015, 46: 1245-1249. PMID: 25828235, PMCID: PMC4414872, DOI: 10.1161/strokeaha.114.008171.Peer-Reviewed Original ResearchConceptsParenchymal hemorrhageIntravenous alteplaseEndovascular therapyBaseline imagingLesion volumeLow cerebral blood volumePerfusion Imaging EvaluationIschemic stroke patientsEndovascular reperfusion therapySingle independent predictorRoutine clinical practiceCerebral blood volumeMagnetic resonance imagingRegional reperfusionParenchymal hematomaReperfusion therapyIndependent predictorsEarly followRisk stratificationStroke patientsImaging evaluationNormal perfusionVLCBVBlood volumePatients