2020
Examining the role of muscarinic M5 receptors in VTA cholinergic modulation of depressive-like and anxiety-related behaviors in rats
Nunes EJ, Rupprecht LE, Foster DJ, Lindsley CW, Conn PJ, Addy NA. Examining the role of muscarinic M5 receptors in VTA cholinergic modulation of depressive-like and anxiety-related behaviors in rats. Neuropharmacology 2020, 171: 108089. PMID: 32268153, PMCID: PMC7313677, DOI: 10.1016/j.neuropharm.2020.108089.Peer-Reviewed Original ResearchConceptsSucrose preference testVentral tegmental areaMuscarinic M5 receptorsCholinergic toneM5 receptorsBehavioral effectsFemale ratsDepressive-like behavioral effectsIntra-VTA infusionAnxiogenic-like effectsAcetylcholinesterase inhibitor physostigmineAnxiety-related behaviorVTA administrationCholinergic modulationCholinergic receptorsMuscarinic receptorsInhibitor physostigmineSwim testTegmental areaMale ratsMood disordersVTA infusionsFST behaviorRatsPhysostigmine
2010
Sensitization of Rapid Dopamine Signaling in the Nucleus Accumbens Core and Shell After Repeated Cocaine in Rats
Addy N, Daberkow D, Ford J, Garris P, Wightman R. Sensitization of Rapid Dopamine Signaling in the Nucleus Accumbens Core and Shell After Repeated Cocaine in Rats. Journal Of Neurophysiology 2010, 104: 922-931. PMID: 20554845, PMCID: PMC2934942, DOI: 10.1152/jn.00413.2010.Peer-Reviewed Original ResearchConceptsAcute cocaine challengeCocaine challengeNucleus accumbens coreWithdrawal periodDopamine sensitizationShort withdrawal periodDopamine releaseDopamine neurotransmissionFast-scan cyclic voltammetryAccumbens coreMale Sprague-Dawley ratsSubsequent cocaine challengeSprague-Dawley ratsLonger withdrawal periodsCocaine-treated subjectsPre-exposed subjectsRepeated CocaineDaily injectionsAcute cocaineDopaminergic responseCocaine exposureDopamine overflowNAc coreDopamine uptakeUptake inhibition
2001
Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats
Levin E, Addy N, Nakajima A, Christopher N, Seidler F, Slotkin T. Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats. Brain Research 2001, 130: 83-89. PMID: 11557096, DOI: 10.1016/s0165-3806(01)00215-2.Peer-Reviewed Original ResearchConceptsFigure-8 apparatusPostnatal CPF exposureCPF exposureEarly neonatal exposureMuscarinic cholinergic controlNeonatal chlorpyrifos exposurePersistent behavioral effectsRadial mazeT-mazeNicotinic cholinergic antagonistBrain cell developmentReference memory impairmentRadial arm mazeReference memory errorsPNDs 11Neonatal exposurePND 1Muscarinic antagonistNeonatal periodCholinergic antagonistsCholinergic controlNeurochemical changesRate of habituationCPF groupLong-term effects