2015
Neuropathology of Traumatic Brain Injury: Comparison of Penetrating, Nonpenetrating Direct Impact and Explosive Blast Etiologies
de Lanerolle NC, Kim JH, Bandak FA. Neuropathology of Traumatic Brain Injury: Comparison of Penetrating, Nonpenetrating Direct Impact and Explosive Blast Etiologies. Seminars In Neurology 2015, 35: 012-019. PMID: 25714863, DOI: 10.1055/s-0035-1544240.Peer-Reviewed Original ResearchConceptsClosed head injuryTraumatic brain injuryDiffuse axonal injuryAxonal injuryMild TBIHead injuryBrain injurySevere closed head injuryModerate traumatic brain injuryModerate closed head injuryMild traumatic brain injuryAnimal TBI modelsMicroglial activationNeuronal injuryTBI modelCerebral vasculatureInjuryNeuropathologyGross disruptionHuman brainBlunt impactUnique patternHumansActivationAstrocytes
2010
Astrocytes and Epilepsy
de Lanerolle NC, Lee TS, Spencer DD. Astrocytes and Epilepsy. Neurotherapeutics 2010, 7: 424-438. PMID: 20880506, PMCID: PMC5084304, DOI: 10.1016/j.nurt.2010.08.002.Peer-Reviewed Original ResearchConceptsSeizure focusReactive astrocytesCausation of seizuresGlial fibrillary acidic proteinHippocampal seizure focusRole of astrocytesTemporal lobe epilepsyFibrillary acidic proteinPositive reactive astrocytesNonsclerotic hippocampiHippocampal sclerosisSclerotic hippocampusSubicular neuronsLobe epilepsyEpileptiform activityInflammatory functionsAstrocytesAction potentialsAcidic proteinPotassium ion channelsVascular interfaceEpilepsyHippocampusPrecise roleHuman brain
1999
Differential Neuronal and Glial Relations with Parameters of Ictal Discharge in Mesial Temporal Lobe Epilepsy
Spencer S, Kim J, DeLanerolle N, Spencer D. Differential Neuronal and Glial Relations with Parameters of Ictal Discharge in Mesial Temporal Lobe Epilepsy. Epilepsia 1999, 40: 708-712. PMID: 10368067, DOI: 10.1111/j.1528-1157.1999.tb00767.x.Peer-Reviewed Original ResearchConceptsGlial densityTemporal lobe epilepsyNeuronal densitySpontaneous seizuresLobe epilepsyIctal dischargesSeizure onsetMesial temporal lobe epilepsyElectrical seizure durationHippocampal seizure onsetPercentage of seizuresInterictal-ictal transitionEEG recordingsSeizure durationSeizure parametersPatient's seizuresSeizure propagationPathologic analysisHippocampal fieldsEpilepsy pathogenesisIntracranial EEG recordingsTL resectionSeizuresSynaptic changesPatients
1995
Hippocampal MRI volumetrics and temporal lobe substrates in medial temporal lobe epilepsy
Luby M, Spencer D, Kim J, deLanerolle N, McCarthy G. Hippocampal MRI volumetrics and temporal lobe substrates in medial temporal lobe epilepsy. Magnetic Resonance Imaging 1995, 13: 1065-1071. PMID: 8750318, DOI: 10.1016/0730-725x(95)02014-k.Peer-Reviewed Original ResearchConceptsMedial temporal lobe epilepsyNeuronal cell lossTemporal lobe epilepsySignificant neuronal cell lossComplete seizure controlMesial temporal sclerosisSeizure controlHippocampal atrophyLobe epilepsyCell lossMagnetic resonance imagingMRI volumetricsMass lesionLoss groupMTS groupTemporal lobeVolumetric atrophyCA fieldsCell countIntractable temporal lobe seizuresMesial temporal sclerosis groupTemporal lobe epilepsy groupAnteromedial temporal lobe resectionGlial cell countsInvasive electrode monitoring
1987
Corticotroph Cell Pituitary Adenoma Within an Ovarian Teratoma
Axiotis C, Lippes H, Merino M, deLanerolle N, Stewart A, Kinder B. Corticotroph Cell Pituitary Adenoma Within an Ovarian Teratoma. The American Journal Of Surgical Pathology 1987, 11: 218-224. PMID: 3548446, DOI: 10.1097/00000478-198703000-00007.Peer-Reviewed Original ResearchConceptsPituitary adenomasOvarian teratomaBenign cystic ovarian teratomaNormalization of ACTHCareful clinical evaluationBenign cystic teratomaSevere Cushing's syndromeCystic ovarian teratomaLack of suppressionCorticotroph cell adenomasCorticotroph tumor cellsSustained hypercortisolemiaCushing's syndromePituitary massACTH immunoreactivityCystic teratomaOvarian tumorsClinical evaluationCortisol productionTumor massCell adenomaCortisol levelsAdenomasTumor cellsTeratoma