Hypothalamic-pituitary-adrenal axis and sympatho-adreno-medullary responses during stress-induced and drug cue-induced cocaine craving states
Sinha R, Talih M, Malison R, Cooney N, Anderson GM, Kreek MJ. Hypothalamic-pituitary-adrenal axis and sympatho-adreno-medullary responses during stress-induced and drug cue-induced cocaine craving states. Psychopharmacology 2003, 170: 62-72. PMID: 12845411, DOI: 10.1007/s00213-003-1525-8.Peer-Reviewed Original ResearchConceptsCocaine-dependent individualsDrug cuesDependent individualsDrug cravingElicit drug cravingStress system activationBrain stress circuitsCue-induced cocaineLikelihood of relapseImagery procedureNeutral imagerySubjective anxietySympatho-adrenoStress imageryPsychobiological changesStressful situationsSubjective ratingsCravingCardiovascular measuresLaboratory sessionsSignificant activationStimuliStress circuitsConclusionsThe findingsCues