2023
Genomic and phenotypic analyses suggest moderate fitness differences among Zika virus lineages
Oliveira G, Vogels C, Zolfaghari A, Saraf S, Klitting R, Weger-Lucarelli J, P Leon K, Ontiveros C, Agarwal R, Tsetsarkin K, Harris E, Ebel G, Wohl S, Grubaugh N, Andersen K. Genomic and phenotypic analyses suggest moderate fitness differences among Zika virus lineages. PLOS Neglected Tropical Diseases 2023, 17: e0011055. PMID: 36753510, PMCID: PMC9907835, DOI: 10.1371/journal.pntd.0011055.Peer-Reviewed Original ResearchMeSH KeywordsAedesAnimalsEvolution, MolecularGenomicsHumansMosquito VectorsZika VirusZika Virus InfectionConceptsHuman primary cellsFitness differencesVirus lineagesRapid molecular evolutionPrimary cellsShort generation timeAmino acid sitesFitness changesHigh mutation ratePhenotypic evolutionMolecular evolutionPositive selectionMutation rateLineagesPhenotypic analysisPhenotypic changesRNA virusesGeneration timeRecombinant virusesAedes aegypti mosquitoesReplicative fitnessFitnessAegypti mosquitoesMosquitoesZika virus
2022
Translating virus evolution into epidemiology
Grubaugh ND. Translating virus evolution into epidemiology. Cell Host & Microbe 2022, 30: 444-448. PMID: 35421340, DOI: 10.1016/j.chom.2022.03.006.Peer-Reviewed Original Research
2021
Early Release - Tracing the Origin, Spread, and Molecular Evolution of Zika Virus in Puerto Rico, 2016–2017 - Volume 27, Number 11—November 2021 - Emerging Infectious Diseases journal - CDC
Santiago GA, Kalinich CC, Cruz-López F, González GL, Flores B, Hentoff A, Charriez KN, Fauver JR, Adams LE, Sharp TM, Black A, Bedford T, Ellis E, Ellis B, Waterman SH, Paz-Bailey G, Grubaugh ND, Muñoz-Jordán JL. Early Release - Tracing the Origin, Spread, and Molecular Evolution of Zika Virus in Puerto Rico, 2016–2017 - Volume 27, Number 11—November 2021 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2021, 27: 2971-2973. PMID: 34670646, PMCID: PMC8544999, DOI: 10.3201/eid2711.211575.Peer-Reviewed Original Research
2020
We shouldn’t worry when a virus mutates during disease outbreaks
Grubaugh ND, Petrone ME, Holmes EC. We shouldn’t worry when a virus mutates during disease outbreaks. Nature Microbiology 2020, 5: 529-530. PMID: 32071422, PMCID: PMC7095397, DOI: 10.1038/s41564-020-0690-4.Peer-Reviewed Original Research
2019
Twenty years of West Nile virus spread and evolution in the Americas visualized by Nextstrain
Hadfield J, Brito AF, Swetnam DM, Vogels CBF, Tokarz RE, Andersen KG, Smith RC, Bedford T, Grubaugh ND. Twenty years of West Nile virus spread and evolution in the Americas visualized by Nextstrain. PLOS Pathogens 2019, 15: e1008042. PMID: 31671157, PMCID: PMC6822705, DOI: 10.1371/journal.ppat.1008042.Peer-Reviewed Original Research
2017
Mosquitoes Transmit Unique West Nile Virus Populations during Each Feeding Episode
Grubaugh ND, Fauver JR, Rückert C, Weger-Lucarelli J, Garcia-Luna S, Murrieta RA, Gendernalik A, Smith DR, Brackney DE, Ebel GD. Mosquitoes Transmit Unique West Nile Virus Populations during Each Feeding Episode. Cell Reports 2017, 19: 709-718. PMID: 28445723, PMCID: PMC5465957, DOI: 10.1016/j.celrep.2017.03.076.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBirdsCulicidaeDNA, MitochondrialEvolution, MolecularGenetic VariationInsect VectorsPhenotypeRNA, ViralSalivaWest Nile FeverWest Nile virusConceptsGenetic diversityNovel virus variantsWNV genetic diversityMost genetic diversityComplex evolutionary forcesVirus populationsEvolutionary forcesWest Nile virusGenetic driftInfection phenotypesWNV variantsIndividual mosquitoesIntrahost variantsVirus variantsTransmission cyclePopulation levelMosquitoesDiversityContinuous threatNile virusVariantsArthropodsChikungunya virusVirusLarge epidemics