2011
Impaired lymphatic contraction associated with immunosuppression
Liao S, Cheng G, Conner DA, Huang Y, Kucherlapati RS, Munn LL, Ruddle NH, Jain RK, Fukumura D, Padera TP. Impaired lymphatic contraction associated with immunosuppression. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 18784-18789. PMID: 22065738, PMCID: PMC3219138, DOI: 10.1073/pnas.1116152108.Peer-Reviewed Original ResearchConceptsEndothelial nitric oxide synthaseLymphatic contractionsLymphatic functionImmune responseAntigen-presenting cellsNitric oxide synthaseEffective immune responseUnique mouse modelLymphatic vessel contractionLymphatic vessel functionLymph nodesAutoreactive responsesMultiple sclerosisVessel contractionInflammatory conditionsInducible NOSOxide synthaseMouse modelLymphatic metastasisVessel functionLymphatic endothelial cellsNitric oxideEndothelial cellsIntravital imagingPotential mechanisms
2000
Kinetics and Cellular Origin of Cytokines in the Central Nervous System: Insight into Mechanisms of Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis
Juedes A, Hjelmström P, Bergman C, Neild A, Ruddle N. Kinetics and Cellular Origin of Cytokines in the Central Nervous System: Insight into Mechanisms of Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis. The Journal Of Immunology 2000, 164: 419-426. PMID: 10605038, DOI: 10.4049/jimmunol.164.1.419.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCentral Nervous SystemChemokinesCytokinesEncephalomyelitis, Autoimmune, ExperimentalFemaleImmunophenotypingInflammation MediatorsInjections, SubcutaneousInterferon-gammaKineticsLymphocyte ActivationMacrophagesMiceMice, Inbred C57BLMicrogliaMolecular Sequence DataMyelin ProteinsMyelin-Associated GlycoproteinMyelin-Oligodendrocyte GlycoproteinSpleenTh1 CellsTh2 CellsTumor Necrosis Factor-alphaConceptsMyelin oligodendrocyte glycoproteinExperimental autoimmune encephalomyelitisAutoimmune encephalomyelitisOligodendrocyte glycoproteinTNF-alphaT cellsDay 7IFN-inducible protein-10TNF-alpha-producing cellsMonocyte chemotactic protein-1MOG35-55 peptideChronic clinical courseAnti-inflammatory cytokinesCD4 T cellsCourse of diseaseChemotactic protein-1Sensitive single-cell assayCellular originTNF-alpha productionRecruitment of macrophagesCentral nervous systemMOG35-55Clinical courseTh1 cytokinesTh2 cytokines