2013
Lymphatic Vessel Function in Head and Neck Inflammation
Truman LA, A-Gonzalez N, Bentley KL, Ruddle NH. Lymphatic Vessel Function in Head and Neck Inflammation. Lymphatic Research And Biology 2013, 11: 187-192. PMID: 24044758, PMCID: PMC3780307, DOI: 10.1089/lrb.2013.0013.Peer-Reviewed Original ResearchConceptsIndividual lymphatic endothelial cellsLymphatic endothelial cellsRed fluorescent reporterEndothelial cellsLymphatic vesselsTranscription factorsRegulatory elementsFaithful expressionProx1 expressionLymphatic vessel functionSingle cellsReporter miceLymphangiogenesisTd-TomatoJackson LaboratoryCellsVivoTdTomatoExpressionProx1TransgeneReporterImmune responseVessel functionMice
2011
Resident B cells regulate thymic expression of myelin oligodendrocyte glycoprotein
Akirav EM, Xu Y, Ruddle NH. Resident B cells regulate thymic expression of myelin oligodendrocyte glycoprotein. Journal Of Neuroimmunology 2011, 235: 33-39. PMID: 21550671, PMCID: PMC3157307, DOI: 10.1016/j.jneuroim.2011.03.013.Peer-Reviewed Original ResearchConceptsB cellsB cell-deficient μMT miceMyelin oligodendrocyte glycoproteinResident B cellsThymic B cellsCortico-medullary junctionMinor cell populationProduction of LTInsulin mRNA expressionΜMT miceEpithelial cell numberOligodendrocyte glycoproteinThymic expressionAntigen expressionMRNA expressionNormal tissuesCell populationsCell numberCellsExpressionLtUnexpected roleBiological roleLymphotoxinMice
2008
Antigen‐induced Lymph Node Remodeling: LVs, HEVs and Conduits
Stranford S, Liao S, Bentley K, Ruddle F, Ruddle N. Antigen‐induced Lymph Node Remodeling: LVs, HEVs and Conduits. The FASEB Journal 2008, 22: 392.3-392.3. DOI: 10.1096/fasebj.22.1_supplement.392.3.Peer-Reviewed Original ResearchHigh endothelial venulesLymph nodesAntigen encounterLymphatic vesselsLymph node remodelingLYVE-1T cell areasSecondary lymphoid organsAntigen-specific lymphocytesER-TR7Lymphoid organsAfferent lymphaticsEndothelial venulesMice transgenicTransgenic miceVascular interactionsDay 4Endothelial cellsAbluminal surfaceLymphocytesAntigenMarkersExpressionEGFP expressionVessels
1999
Murine neurofibroma reversion by antisense RNA for HTLV-I tax
Li C, Horowitz M, Ruddle N. Murine neurofibroma reversion by antisense RNA for HTLV-I tax. Science China Life Sciences 1999, 42: 8-16. PMID: 18726492, DOI: 10.1007/bf02881742.Peer-Reviewed Original ResearchAntisense RNATax proteinCellular genesEndogenous cellular genesReversed transcriptional orientationNeurofibroma cellsCell morphologyNeurofibroma cell linesTranscriptional orientationHTLV-I Tax proteinProto-oncogene expressionActin mRNAC-MycRetrovirus vectorGenesProteinRNACell linesTax geneMRNAM-CSFTax cDNAExpressionGrowth characteristicsPhenotype
1994
10 Studies of Tolerance, Inflammation, and Autoimmunity in Transgenic Mice
Antonia S, Elliott E, Guerder S, Picarella D, Ruddle N, Flavell R. 10 Studies of Tolerance, Inflammation, and Autoimmunity in Transgenic Mice. 1994, 155-174. DOI: 10.1016/b978-0-12-105760-2.50014-5.Peer-Reviewed Original ResearchAutoreactive T cellsT cellsTransgenic miceT antigen transgenic miceLocal antigen presentationSpecific T cellsInfluence of cytokinesAutoreactive cellsAntigen presentationTissue destructionEffective antigenAutoimmunityClonal expansionMiceTissue remodelingStudy of toleranceAntigenIsletsCellsTissueActivationInflammationHyperplasiaCytokinesExpression