Featured Publications
ERAS Protocol Options for Perioperative Pain Management of Substance Use Disorder in the Ambulatory Surgical Setting
Zwolinski N, Patel K, Vadivelu N, Kodumudi G, Kaye A. ERAS Protocol Options for Perioperative Pain Management of Substance Use Disorder in the Ambulatory Surgical Setting. Current Pain And Headache Reports 2023, 27: 65-79. PMID: 37079258, PMCID: PMC10116112, DOI: 10.1007/s11916-023-01108-3.Peer-Reviewed Original ResearchConceptsSubstance use disordersSubstance use disorder patientsAmbulatory patientsUse disordersDisorder patientsERAS protocolPerioperative pain managementAmbulatory surgery settingHospital quality metricsAmbulatory surgical settingAmbulatory surgery casesPerioperative protocolPain managementAdverse outcomesAmbulatory surgeryPharmacodynamic profileSurgery settingAmbulatory proceduresSurgery casesClinical dataEarly recoveryAbused substancesSurgical settingPatientsSubspecialty groupsEvolving Therapeutic Roles of Nasogastric Tubes: Current Concepts in Clinical Practice
Vadivelu N, Kodumudi G, Leffert L, Pierson D, Rein L, Silverman M, Cornett E, Kaye A. Evolving Therapeutic Roles of Nasogastric Tubes: Current Concepts in Clinical Practice. Advances In Therapy 2023, 40: 828-843. PMID: 36637690, PMCID: PMC9838367, DOI: 10.1007/s12325-022-02406-9.Peer-Reviewed Original ResearchConceptsNasogastric tubeShort-term parenteral nutritionTerm parenteral nutritionManagement of complicationsAdministration of medicationsMultiple medical specialtiesTechnique of insertionResuscitative toolBowel obstructionParenteral nutritionChronic careTherapeutic roleClinical practiceComplicationsSurgical specialtiesCurrent conceptsMedical specialtiesRecent updatesCorrect positioningSpecialtiesContraindicationsMedicationsObstructionStomachAdministrationEnhanced Recovery After Surgery: Opioid Sparing Strategies After Discharge: A Review
Rajput K, Shergill S, Chow RM, Vadivelu N, Kaye AD. Enhanced Recovery After Surgery: Opioid Sparing Strategies After Discharge: A Review. Current Pain And Headache Reports 2022, 26: 93-102. PMID: 35072920, DOI: 10.1007/s11916-022-01009-x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsOpioid usePersistent post-surgical painNon-opioid strategiesNon-opioid therapiesOpioid-sparing strategiesOverprescribing of opioidsPostoperative pain scoresMultimodal analgesic approachPost-surgical painSide effect profileNon-opioid analgesicsRecent FindingsSeveral studiesERAS protocolOpioid protocolAnalgesic approachBreakthrough painHospital stayMultimodal analgesiaPain scoresAcute painOral ketaminePostoperative periodEffect profilePatient recoveryGood quality researchAmbulatory Pain Management in the Pediatric Patient Population
Oliver JA, Oliver LA, Aggarwal N, Baldev K, Wood M, Makusha L, Vadivelu N, Lichtor L. Ambulatory Pain Management in the Pediatric Patient Population. Current Pain And Headache Reports 2022, 26: 15-23. PMID: 35129824, DOI: 10.1007/s11916-022-00999-y.Peer-Reviewed Original ResearchConceptsPain managementPostoperative painPediatric ambulatory surgical patientsPostoperative pain controlAmbulatory surgical patientsSevere postoperative painExtent of painPeripheral nerve blocksPediatric ambulatory surgeryPediatric patient populationNon-pharmacological techniquesRandomized control studyEvidence-based approachMultimodal analgesiaPain controlSurgical patientsNerve blockPediatric populationAmbulatory surgeryPatient populationMost centersControl studyPainScientific evidenceMultimodal approachAnalgesia for Gynecologic Oncologic Surgeries: A Narrative Review
Patel K, Shergill S, Vadivelu N, Rajput K. Analgesia for Gynecologic Oncologic Surgeries: A Narrative Review. Current Pain And Headache Reports 2022, 26: 1-13. PMID: 35118596, DOI: 10.1007/s11916-022-00998-z.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHyperthermic intraperitoneal chemotherapyCytoreductive surgeryPain managementNarrative reviewOptimal perioperative pain managementGynecologic oncologic surgeryPerioperative analgesic planPostoperative pain managementPerioperative pain managementLocal anesthetic infiltrationInvasive cancer surgeryMultimodal analgesicsPreemptive analgesiaMultimodal analgesiaPostoperative painAnalgesic planAnesthetic infiltrationGynecologic malignanciesIntraperitoneal chemotherapyPerioperative periodSurgery protocolThoracic epiduralCancer surgeryChronic painNeuraxial techniquesNovel Regional Anesthesia for Outpatient Surgery
Li J, Lam D, King H, Credaroli E, Harmon E, Vadivelu N. Novel Regional Anesthesia for Outpatient Surgery. Current Pain And Headache Reports 2019, 23: 69. PMID: 31372836, DOI: 10.1007/s11916-019-0809-6.Peer-Reviewed Original ResearchConceptsNerve blockAdverse eventsOutpatient surgeryLower extremity nerve blocksPeripheral nerve blocksPotential adverse eventsProper patient managementPerioperative analgesiaAmbulatory surgerySafe modalityShoulder surgeryAmbulatory proceduresRegional anesthesiaPatient managementUltrasound guidanceProper patientLower riskSurgeryPatient choiceMultidisciplinary effortAnalgesiaAnesthesiaPatientsUltrasound for peripheral and arterial access
Oliver LA, Oliver JA, Ohanyan S, Park W, Benelyahoo A, Vadivelu N. Ultrasound for peripheral and arterial access. Best Practice & Research Clinical Anaesthesiology 2019, 33: 523-537. PMID: 31791568, DOI: 10.1016/j.bpa.2019.10.002.Peer-Reviewed Original ResearchConceptsHealth care professionalsArterial accessCare professionalsNumerous patient factorsChronic kidney diseasePeripheral intravenous accessPeripheral venous accessSkilled health care professionalsArterial line placementStandard landmark techniqueIntravenous accessPatient factorsAccess placementVenous accessKidney diseasePatient populationVascular accessSurgical centersUltrasound guidanceUrgent careLandmark techniqueLine placementDrug useBlood vesselsSuccess rateEndometriosis Pain Management: a Review
Carlyle D, Khader T, Lam D, Vadivelu N, Shiwlochan D, Yonghee C. Endometriosis Pain Management: a Review. Current Pain And Headache Reports 2020, 24: 49. PMID: 32671581, DOI: 10.1007/s11916-020-00884-6.Peer-Reviewed Original ResearchConceptsSurgical managementGnRH agonists/antagonistsNonsteroidal anti-inflammatory drugsPain management optionsAnti-inflammatory drugsAgonists/antagonistsNerve ablationPresacral neurectomyMedical managementTreatment modalitiesAromatase inhibitorsChallenging diseaseSurgical techniqueReviewThe purposeNeurectomyExperimental pharmaceuticalsManagement optionsAblationHysterectomyOophorectomyEndometriosisRegimensResectionDanazolPatientsUltrasound-Guided Neuraxial Anesthesia
Li J, Krishna R, Zhang Y, Lam D, Vadivelu N. Ultrasound-Guided Neuraxial Anesthesia. Current Pain And Headache Reports 2020, 24: 59. PMID: 32812182, DOI: 10.1007/s11916-020-00895-3.Peer-Reviewed Original ResearchConceptsNeuraxial anesthesiaHigher first-attempt success rateFirst-attempt success rateNon-obstetric patientsAcute pain managementAttempt success ratePurpose of ReviewTherePain managementRegional anesthesiaNeuraxial spacePatient safety implicationsVertebral levelAnesthesiaOverall efficacyRecent FindingsUltrasoundNeedle passPatient safetyCatheter visualizationUltrasound utilizationClinical accuracySuccess rateCommon typeClinical applicationUltrasoundPatientsAcute Pain Management of Chronic Pain Patients in Ambulatory Surgery Centers
Rajput K, Vadivelu N. Acute Pain Management of Chronic Pain Patients in Ambulatory Surgery Centers. Current Pain And Headache Reports 2021, 25: 1. PMID: 33443656, DOI: 10.1007/s11916-020-00922-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPerioperative pain managementAmbulatory surgery centersNon-opioid analgesicsPain managementSurgery centersIntrathecal pain pumpOpioid-tolerant patientsPostoperative opioid requirementsAcute pain managementChronic opioid useProportion of patientsSubset of patientsChronic pain patientsSame-day admission patientsSpinal cord stimulatorPurpose of ReviewWithOpioid requirementsPostoperative opioidsMalignant painMultimodal analgesiaPerioperative painOpioid toleranceOpioid usePain specialistsPain patientsAnalysis of Multiple Routes of Analgesic Administration in the Immediate Postoperative Period: a 10-Year Experience
Vadivelu N, Kai AM, Dai F, Dabu-Bondoc S. Analysis of Multiple Routes of Analgesic Administration in the Immediate Postoperative Period: a 10-Year Experience. Current Pain And Headache Reports 2019, 23: 22. PMID: 30854578, DOI: 10.1007/s11916-019-0754-4.Peer-Reviewed Original ResearchConceptsPain scoresAnalgesic administrationPostoperative painPost-anesthesia care unitYale-New Haven HospitalImmediate postoperative painPostoperative pain scoresPurpose of ReviewAnSignificant pain reliefImmediate postoperative periodConsecutive surgical casesTime of dischargeRoute of administrationCommon routeAdverse side effectsNew Haven HospitalIndividual analgesicsNeuraxial routeAnalgesia administrationNeuraxial analgesiaPain reliefPostoperative periodSynergistic analgesiaCare unitParenteral route
2019
Challenges of Robotic Gynecologic Surgery in Morbidly Obese Patients and How to Optimize Success
Menderes G, Gysler SM, Vadivelu N, Silasi DA. Challenges of Robotic Gynecologic Surgery in Morbidly Obese Patients and How to Optimize Success. Current Pain And Headache Reports 2019, 23: 51. PMID: 31263977, DOI: 10.1007/s11916-019-0788-7.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsObese patientsGynecologic surgeryRobotic gynecologic surgeryPerioperative riskRobotic surgeryInvasive approachInvasive surgeryAdequate preoperative optimizationMorbidly obese patientsNon-obese counterpartsUse of laparoscopyIncidence of mortalityGynecologic patientsPerioperative complicationsPreoperative optimizationPerioperative managementLaparoscopic approachObese populationOpen surgeryPostoperative managementHeart diseaseExtreme BMIPatientsSurgeryPhysiologic adaptations
2016
Role of Alternative Therapies for Chronic Pain Syndromes
Thomas DA, Maslin B, Legler A, Springer E, Asgerally A, Vadivelu N. Role of Alternative Therapies for Chronic Pain Syndromes. Current Pain And Headache Reports 2016, 20: 29. PMID: 27038968, DOI: 10.1007/s11916-016-0562-z.Peer-Reviewed Original ResearchConceptsChronic painWhole-body cryotherapyExercise therapyPain statesAlternative therapiesComplimentary therapiesLong-term pain statesChronic pain syndromePhysical exercise therapyTreatment of headacheCognitive behavior therapyNeck painPain syndromeAlternate therapyBiofeedback therapyPain psychologySham controlsPainHerbal supplementsAlternative medicineTherapyBiopsychosocial approachBehavior therapyBiopsychosocial modelNew modalityFacial Pain Update: Advances in Neurostimulation for the Treatment of Facial Pain
Maniam R, Kaye AD, Vadivelu N, Urman RD. Facial Pain Update: Advances in Neurostimulation for the Treatment of Facial Pain. Current Pain And Headache Reports 2016, 20: 24. PMID: 26896948, DOI: 10.1007/s11916-016-0553-0.Peer-Reviewed Original ResearchConceptsInterventional pain proceduresCraniofacial painFacial painPharmacological therapyPain proceduresHigh-frequency spinal cord stimulationPersistent idiopathic facial painPeripheral nerve field stimulationIdiopathic facial painInterventional pain techniquesSphenopalatine ganglion stimulationTrigeminal neuropathic painTraditional pharmacological therapyInterventional pain therapySmall patient cohortSpinal cord stimulationDeep brain stimulationInvasive implantation techniquesGanglion stimulationNeuropathic painPain statesPain therapyTrigeminal neuralgiaCord stimulationPatient cohortEfficacy and Safety of Nonopioid Analgesics in Perioperative Pain Control.
Thomas DA, West M, Legler A, Maslin B, Kim RK, Vadivelu N. Efficacy and Safety of Nonopioid Analgesics in Perioperative Pain Control. Current Drug Safety 2016, 11: 196-205. PMID: 27113953, DOI: 10.2174/1574886311666160426130444.Peer-Reviewed Original ResearchConceptsPain controlNonopioid analgesicsSide effectsContemporary pain managementOptimum pain controlPerioperative pain controlAcute postoperative painPostoperative pain controlMultiple side effectsNonopioid medicationsPostoperative painTolerant patientsPain managementSafety profileAnalgesicsRecent dataComorbiditiesMedicationsOpioidsPainPatientsSurgeryMainstayControlPerioperative Safety of Warfarin Therapy and Reversal.
Maslin B, Springer E, Zhu R, Kodumudi V, Vadivelu N. Perioperative Safety of Warfarin Therapy and Reversal. Current Drug Safety 2016, 11: 149-55. PMID: 26674352, DOI: 10.2174/1574886311666151217121553.Peer-Reviewed Original ResearchConceptsWarfarin therapyEmergent surgeryPatient groupMultidisciplinary consensus guidelinesRisk stratification algorithmCertain patient groupsVulnerable patient groupRegional anesthetic techniquesClinical decision pointsUnited States populationThromboembolic consequencesPerioperative periodPerioperative safetyBlood lossPerioperative careProcedural complicationsClinical outcomesPreoperative patientsAnesthetic techniqueRetrospective studyConsensus guidelinesPerioperative cliniciansClinical trialsCoordinated careClinical studies
2014
Transvaginal cholecystectomy learning curve
Wood SG, Dai F, Dabu-Bondoc S, Mikhael H, Vadivelu N, Duffy A, Roberts KE. Transvaginal cholecystectomy learning curve. Surgical Endoscopy 2014, 29: 1837-1841. PMID: 25294548, DOI: 10.1007/s00464-014-3873-3.Peer-Reviewed Original ResearchConceptsOperative timeTransvaginal cholecystectomyTVC patientsAcademic centersAverage age 41Learning curveResultsSixty-one patientsLaparoscopic cholecystectomy patientsAverage operative timeFellowship-trained surgeonsCholecystectomy patientsFemale patientsLC patientsMean ageMethodsThis studyAge 41PatientsSecond quartileSurgical repertoireSame time periodThird quartileLack of exposureFellowship trainingQuartileInterested surgeonsIntrathecal drug delivery for chronic pain management-scope, limitations and future
Czernicki M, Sinovich G, Mihaylov I, Nejad B, Kunnumpurath S, Kodumudi G, Vadivelu N. Intrathecal drug delivery for chronic pain management-scope, limitations and future. Journal Of Clinical Monitoring And Computing 2014, 29: 241-249. PMID: 25173564, DOI: 10.1007/s10877-014-9607-1.Peer-Reviewed Original ResearchConceptsIntrathecal drug delivery systemsChronic painOptimal medical managementIntrathecal drug deliveryDifferent implantation techniquesLicensing of drugsSevere morbidityMedical managementMuscle spasmMain indicationsIntrathecal useInvasive techniquesOutcome studiesPainAdverse effectsHealthcare practitionersImplantation techniqueTherapyDrug delivery systemsTherapy systemReview articleDelivery systemDate knowledgeMorbiditySpasmPerioperative dilemma: challenges of the management of a patient on mega doses of morphine and methadone.
Kaye AD, Alian AA, Vadivelu N, Chung KS. Perioperative dilemma: challenges of the management of a patient on mega doses of morphine and methadone. Journal Of Opioid Management 2014, 10: 69-72. PMID: 24604572, DOI: 10.5055/jom.2014.0194.Peer-Reviewed Original ResearchConceptsOpioid-induced hyperalgesiaHigh dosesHigh-dose opioidsCancer-related painPresent case reportMega dosesOpioid requirementsOpioid managementMetastatic leiomyosarcomaAgonist clonidineCase reportPotent analgesicOpioidsPatientsSuccessful managementDosesPainMethadoneMorphineHyperalgesiaClonidineAnalgesicsLeiomyosarcomaManagementAntagonist
2013
Comparison of immediate postoperative pain after transvaginal versus traditional laparoscopic cholecystectomy
Wood SG, Dabu-Bondoc S, Dai F, Mikhael H, Vadivelu N, Roberts KE. Comparison of immediate postoperative pain after transvaginal versus traditional laparoscopic cholecystectomy. Surgical Endoscopy 2013, 28: 1141-1145. PMID: 24232050, DOI: 10.1007/s00464-013-3294-8.Peer-Reviewed Original ResearchConceptsPost-anesthesia care unitPostoperative opioid useLaparoscopic cholecystectomyLC patientsLC groupTVC patientsOpioid requirementsPain scoresPain medicationPostoperative painOpioid useFour-port laparoscopic cholecystectomyImmediate postoperative pain managementOperating roomImmediate postoperative painIntraoperative opioid requirementsPACU pain scoresTraditional laparoscopic cholecystectomyAverage pain scorePostoperative pain managementLess pain medicationAnesthesia care unitBody mass indexTerms of agePaucity of data