2016
Efficacy and Safety of Nonopioid Analgesics in Perioperative Pain Control.
Thomas DA, West M, Legler A, Maslin B, Kim RK, Vadivelu N. Efficacy and Safety of Nonopioid Analgesics in Perioperative Pain Control. Current Drug Safety 2016, 11: 196-205. PMID: 27113953, DOI: 10.2174/1574886311666160426130444.Peer-Reviewed Original ResearchConceptsPain controlNonopioid analgesicsSide effectsContemporary pain managementOptimum pain controlPerioperative pain controlAcute postoperative painPostoperative pain controlMultiple side effectsNonopioid medicationsPostoperative painTolerant patientsPain managementSafety profileAnalgesicsRecent dataComorbiditiesMedicationsOpioidsPainPatientsSurgeryMainstayControl
2014
Perioperative dilemma: challenges of the management of a patient on mega doses of morphine and methadone.
Kaye AD, Alian AA, Vadivelu N, Chung KS. Perioperative dilemma: challenges of the management of a patient on mega doses of morphine and methadone. Journal Of Opioid Management 2014, 10: 69-72. PMID: 24604572, DOI: 10.5055/jom.2014.0194.Peer-Reviewed Original ResearchConceptsOpioid-induced hyperalgesiaHigh dosesHigh-dose opioidsCancer-related painPresent case reportMega dosesOpioid requirementsOpioid managementMetastatic leiomyosarcomaAgonist clonidineCase reportPotent analgesicOpioidsPatientsSuccessful managementDosesPainMethadoneMorphineHyperalgesiaClonidineAnalgesicsLeiomyosarcomaManagementAntagonist
2010
Buprenorphine: intravenous neuraxial and transdermal applications
Vadivelu N. Buprenorphine: intravenous neuraxial and transdermal applications. 2010, 157-160. DOI: 10.1017/cbo9780511841378.035.ChaptersPain managementAvailable pain medicationsAdjuvant medicationsNeuraxial opioidsPain medicationPain reliefAdverse eventsOpioid analgesicsPain processingMuscle relaxantsPharmacologic principlesNMDA antagonistsLocal anestheticsAnalgesicsCommon dosesClinical settingClinical useParticular drugTransdermal applicationMedicationsCliniciansDrugsAnalgesiaContraindicationsOpioids
2007
Buprenorphine: a unique opioid with broad clinical applications.
Vadivelu N, Hines RL. Buprenorphine: a unique opioid with broad clinical applications. Journal Of Opioid Management 2007, 3: 49-58. PMID: 17367094, DOI: 10.5055/jom.2007.0038.Peer-Reviewed Original ResearchConceptsAnti-inflammatory agentsPartial mu agonistRoute of administrationUnique opioidPerioperative painAdequate analgesiaAnalgesic potentialMu agonistsBroad clinical applicationOpioid addictionAddictive potentialClinical applicationBuprenorphineAgonistsPositive resultsAnalgesiaMedicationsOpioidsPainAdministration