2017
Application of “Omics” and Systems Biology to Sarcoidosis Research
Crouser ED, Fingerlin TE, Yang IV, Maier LA, Nana-Sinkam P, Collman RG, Kaminski N. Application of “Omics” and Systems Biology to Sarcoidosis Research. Annals Of The American Thoracic Society 2017, 14: s445-s451. PMID: 29053026, PMCID: PMC5822413, DOI: 10.1513/annalsats.201707-567ot.Peer-Reviewed Original ResearchConceptsSystems biology researchBiology researchSystems biologyDistinct genetic mechanismsNumerous genetic mutationsField of sarcoidosisGenetic mechanismsDiverse clinical phenotypesOmicsMechanistic underpinningsComprehensive profilingPolygenic diseaseGenetic mutationsDiverse diseasesBiologyAdvanced computational approachesEnormous data setsComputational approachClinical phenotypeOrganismsPolygenicMutationsDisease-related mortalityPhenotypeLife-altering symptoms
2009
Chronic lung diseases
Wu W, Kaminski N. Chronic lung diseases. WIREs Mechanisms Of Disease 2009, 1: 298-308. PMID: 20835999, DOI: 10.1002/wsbm.23.Peer-Reviewed Original ResearchConceptsSystems biology approachBiology approachChronic lung diseaseComplex human diseasesHigh-throughput technologiesLung diseaseSystems biologyHuman diseasesTraditional experimental approachesComplex lung diseaseBiomedical researchExperimental approachSerious economic burdenHigh morbiditySerious threatHuman healthEconomic burdenMortality rateDiseaseBiologyMicroarrayPromising findings
2007
A Functional and Regulatory Map of Asthma
Novershtern N, Itzhaki Z, Manor O, Friedman N, Kaminski N. A Functional and Regulatory Map of Asthma. American Journal Of Respiratory Cell And Molecular Biology 2007, 38: 324-336. PMID: 17921359, PMCID: PMC2258452, DOI: 10.1165/rcmb.2007-0151oc.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAllergensAnimalsAsthmaDisease Models, AnimalGene Expression ProfilingHumansHypersensitivityImmunity, InnateInterleukin-13MiceMice, Inbred AMice, Inbred BALB CMice, Inbred C3HMice, KnockoutModels, BiologicalOligonucleotide Array Sequence AnalysisOvalbuminProtein Interaction MappingReproducibility of ResultsSystems BiologyTranscription, GeneticTransforming Growth Factor beta1ConceptsCo-regulated gene modulesGene expression compendiumProtein interaction networksModule network analysisMouse microarray datasetsSystems-level viewExpression compendiumRegulatory mapGene modulesModule membersFunctional themesInteraction networksKey regulatorAnimal modelsMicroarray datasetsGeneral inductionAnnotation setsChronic inflammatory airway diseasesMorbidity of asthmaInflammatory airway diseasesMechanisms of asthmaAdaptive immune responsesSystem-level approachSimilar roleDistinct responsesTowards Systems Biology of Human Pulmonary Fibrosis
Studer SM, Kaminski N. Towards Systems Biology of Human Pulmonary Fibrosis. Annals Of The American Thoracic Society 2007, 4: 85-91. PMID: 17202296, PMCID: PMC2647618, DOI: 10.1513/pats.200607-139jg.Peer-Reviewed Original ResearchConceptsSystems biology approachBiology approachSystems biologyHigh-throughput genotypingHigh-throughput technologiesMicroarray resultsBiological processesQuantitative phenotypingEnvironmental stimuliFibrosis researchMultiple pathwaysLung phenotypeBiologyGlobal analysisHuman pulmonary fibrosisGenetic polymorphismsIdiopathic pulmonary fibrosisComputational toolsPulmonary fibrosisSystemwide viewHigh-resolution profilesPhenotypePathwayLethal lung diseasePolymorphism