2021
Elevated plasma level of Pentraxin 3 is associated with emphysema and mortality in smokers
Zhang Y, Tedrow J, Nouraie M, Li X, Chandra D, Bon J, Kass DJ, Fuhrman CR, Leader JK, Duncan SR, Kaminski N, Sciurba FC. Elevated plasma level of Pentraxin 3 is associated with emphysema and mortality in smokers. Thorax 2021, 76: 335-342. PMID: 33479043, PMCID: PMC8249179, DOI: 10.1136/thoraxjnl-2020-215356.Peer-Reviewed Original ResearchConceptsAirflow obstructionPlasma levelsLung tissueEmphysema severitySmoking-related lung diseaseAssociation of lungExpiratory airflow obstructionFormer tobacco smokersLevels of PTX3PTX3 gene expressionElevated plasma levelsHyaluronic acid levelsBlood of subjectsPlasma PTX3PTX3 levelsLung functionTobacco exposureClinical outcomesTobacco smokersLung diseasePentraxin 3Predictive biomarkersPTX3 expressionLower riskDisease patterns
2015
Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis Study. Alpha-1 Protocol
Strange C, Senior RM, Sciurba F, O’Neal S, Morris A, Wisniewski SR, Bowler R, Hochheiser HS, Becich MJ, Zhang Y, Leader JK, Methé BA, Kaminski N, Sandhaus RA, Group* F. Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis Study. Alpha-1 Protocol. Annals Of The American Thoracic Society 2015, 12: 1551-1560. PMID: 26153726, PMCID: PMC4627425, DOI: 10.1513/annalsats.201503-143oc.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAlpha 1-Antitrypsin DeficiencyBronchoalveolar LavageCross-Sectional StudiesExercise ToleranceFemaleGenomicsGenotypeHumansMaleMicrobiotaMiddle AgedPhenotypeProspective StudiesPulmonary Disease, Chronic ObstructivePulmonary EmphysemaResearch DesignRespiratory Function TestsSarcoidosisTomography, X-Ray ComputedConceptsAlpha-1 antitrypsin deficiencyAugmentation therapyBronchoalveolar lavageAntitrypsin deficiencyClinical presentationPiZZ individualsAlpha-1-antitrypsin augmentation therapyAlpha-1 antitrypsin genotypeChronic obstructive pulmonary disease phenotypesPulmonary function testingAge 35 yearsVariable clinical presentationCross-sectional studyAlpha-1 antitrypsinIntermediate outcome measuresPulmonary disease phenotypesUnique genetic causeExercise capacityTherapeutic trialsChest tomographyClinical symptomsCOPD pathogenesisCOPD phenotypesFunction testingCOPD StudyRationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) Study. Sarcoidosis Protocol
Moller DR, Koth LL, Maier LA, Morris A, Drake W, Rossman M, Leader JK, Collman RG, Hamzeh N, Sweiss NJ, Zhang Y, O’Neal S, Senior RM, Becich M, Hochheiser HS, Kaminski N, Wisniewski SR, Gibson KF, Group* F. Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) Study. Sarcoidosis Protocol. Annals Of The American Thoracic Society 2015, 12: 1561-1571. PMID: 26193069, PMCID: PMC4627423, DOI: 10.1513/annalsats.201503-172ot.Peer-Reviewed Original ResearchConceptsAlpha-1 antitrypsin deficiencyClinical courseLung microbiomeAntitrypsin deficiencyClinical heterogeneityPathobiology of sarcoidosisTremendous clinical heterogeneityObservational cohort studyPulmonary function testsSystemic inflammatory responsePeripheral blood changesDiagnosis of sarcoidosisSelf-administered questionnaireCohort studyBaseline visitBronchoalveolar lavageFunction testsGranulomatous inflammationSystemic diseaseSarcoidosis phenotypesUrine testingClinical bronchoscopyInflammatory responseSarcoidosis StudyPrognostic biomarker
2014
Bidirectional elastic image registration using B-spline affine transformation
Gu S, Meng X, Sciurba FC, Ma H, Leader J, Kaminski N, Gur D, Pu J. Bidirectional elastic image registration using B-spline affine transformation. Computerized Medical Imaging And Graphics 2014, 38: 306-314. PMID: 24530210, PMCID: PMC4019704, DOI: 10.1016/j.compmedimag.2014.01.002.Peer-Reviewed Original ResearchAlgorithmsHumansImaging, Three-DimensionalNumerical Analysis, Computer-AssistedPattern Recognition, AutomatedRadiographic Image EnhancementRadiographic Image Interpretation, Computer-AssistedRadiography, ThoracicReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueTomography, X-Ray Computed
2013
Assessment of lung volume collapsibility in chronic obstructive lung disease patients using CT
Kundu S, Gu S, Leader JK, Tedrow JR, Sciurba FC, Gur D, Kaminski N, Pu J. Assessment of lung volume collapsibility in chronic obstructive lung disease patients using CT. European Radiology 2013, 23: 1564-1572. PMID: 23494492, PMCID: PMC3657332, DOI: 10.1007/s00330-012-2746-1.Peer-Reviewed Original ResearchConceptsPulmonary function testsUpper lobeLower lobeWhole lungLung lobesChronic obstructive lung disease patientsDisease severityGOLD categoriesObstructive lung disease patientsLung disease patientsMean lung densityTotal lung volumeAssessment of lungLobar volume changesFEV1/Lung functionExpiration volumeFunction testsGOLD classificationInspiration/expirationDisease patientsRV/Air trappingLung volumeCT examinations
2009
The Influence of Radiographic Phenotype and Smoking Status on Peripheral Blood Biomarker Patterns in Chronic Obstructive Pulmonary Disease
Bon JM, Leader JK, Weissfeld JL, Coxson HO, Zheng B, Branch RA, Kondragunta V, Lee JS, Zhang Y, Choi AM, Lokshin AE, Kaminski N, Gur D, Sciurba FC. The Influence of Radiographic Phenotype and Smoking Status on Peripheral Blood Biomarker Patterns in Chronic Obstructive Pulmonary Disease. PLOS ONE 2009, 4: e6865. PMID: 19718453, PMCID: PMC2730536, DOI: 10.1371/journal.pone.0006865.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersCohort StudiesFemaleForced Expiratory VolumeHumansMaleMiddle AgedPulmonary Disease, Chronic ObstructiveSmokingTomography, X-Ray ComputedConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseCurrent smoking statusAirway thickeningSmoking statusPulmonary diseaseBiomarker patternsSerum biomarker patternsSerum biomarker profilesSerum inflammatory proteinsParenchymal phenotypesMeasurements of FEV1Cross-sectional studyMultiplex protein arrayUnique biomarker patternsQuantitative CT measurementsCOPD syndromePhysiologic obstructionSecond percentAirway remodelingExpiratory volumeInflammatory markersParenchymal destructionScreening cohortBiological therapy
2000
Inferior vena cava (pseudo)thrombus: computed tomographic artifact occurring with right heart failure and tricuspid incompetence.
Nissan A, Shaham D, Kaminski N, Bar-Ziv J. Inferior vena cava (pseudo)thrombus: computed tomographic artifact occurring with right heart failure and tricuspid incompetence. Israel Medical Association Journal 2000, 2: 859-61. PMID: 11344759.Peer-Reviewed Original Research