2024
Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals
Korem N, Hillmer A, D’Souza D, Nia A, Levy I, Pietrzak R, Harpaz-Rotem I. Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals. JAMA Network Open 2024, 7: e2432387. PMID: 39250156, PMCID: PMC11385051, DOI: 10.1001/jamanetworkopen.2024.32387.Peer-Reviewed Original Research
2022
Delirium screening in an acute care setting with a machine learning classifier based on routinely collected nursing data: A model development study
Spiller TR, Tufan E, Petry H, Böttger S, Fuchs S, Duek O, Ben-Zion Z, Korem N, Harpaz-Rotem I, von Känel R, Ernst J. Delirium screening in an acute care setting with a machine learning classifier based on routinely collected nursing data: A model development study. Journal Of Psychiatric Research 2022, 156: 194-199. PMID: 36252349, DOI: 10.1016/j.jpsychires.2022.10.018.Peer-Reviewed Original ResearchConceptsDelirium Observation ScaleAcute care settingNursing dataCare settingsSingle tertiary teaching hospitalPatients 18 yearsTertiary teaching hospitalDelirium prediction modelSuch screening programsDelirium screeningAcute careMean ageTeaching hospitalInclusion criteriaScreening programDeliriumPatientsClinical practiceTotal scoreDemographic characteristicsCharacteristic curveScreening procedureModel development studiesRiskAdditional measures
2018
Role of endocannabinoids in the hippocampus and amygdala in emotional memory and plasticity
Segev A, Korem N, Mizrachi Zer-Aviv T, Abush H, Lange R, Sauber G, Hillard C, Akirav I. Role of endocannabinoids in the hippocampus and amygdala in emotional memory and plasticity. Neuropsychopharmacology 2018, 43: 2017-2027. PMID: 29977073, PMCID: PMC6098035, DOI: 10.1038/s41386-018-0135-4.Peer-Reviewed Original ResearchConceptsLong-term potentiationPosttraumatic stress disorderBasolateral amygdalaSituational remindersEmotional memoryFatty acid amide hydrolase inhibitor URB597Fear responsesCB1 receptor antagonist AM251Effects of URB597Receptor antagonist AM251Role of endocannabinoidsDevelopment of PTSDHippocampal CA1 areaTrauma-related cuesEndogenous cannabinoid levelsSevere footshockAntagonist AM251Endocannabinoid contentAEA levelsCA1 areaEffects of exposureRisk factorsFAAH activityTreatment responseFAAH inhibition
2017
Role of beta-catenin and endocannabinoids in the nucleus accumbens in extinction in rats exposed to shock and reminders
Korem N, Lange R, Hillard C, Akirav I. Role of beta-catenin and endocannabinoids in the nucleus accumbens in extinction in rats exposed to shock and reminders. Neuroscience 2017, 357: 285-294. PMID: 28624572, DOI: 10.1016/j.neuroscience.2017.06.015.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderWnt/β-catenin pathwayNucleus accumbensΒ-catenin pathwayΒ-catenin levelsΒ-cateninCannabinoid CB1/2 receptor agonistCB1/2 receptor agonistEndocannabinoid N-arachidonylethanolamineStress-related disordersΒ-catenin expressionReceptor agonistEndocannabinoid systemTherapeutic effectN-arachidonylethanolamineDepressive symptomsDevelopment of psychopathologyImpaired extinctionRatsStress disorderFear memoryTrauma memoriesRapid recoveryReminders modelAccumbensIs susceptibility to cross-language interference domain specific?
Prior A, Degani T, Awawdy S, Yassin R, Korem N. Is susceptibility to cross-language interference domain specific? Cognition 2017, 165: 10-25. PMID: 28458090, DOI: 10.1016/j.cognition.2017.04.006.Peer-Reviewed Original ResearchConceptsExecutive functionL1 interferenceLexical interferenceL2 proficiencySyntactic interferenceSemantic similarity judgment taskSelf-paced reading paradigmSecond language achievementDifferent-script bilingualsGeneral executive functionsNumerical Stroop taskSimilarity judgment taskCross-language interferenceGeneral EF abilityBilingual university studentsEF abilitiesStroop taskJudgment taskL2 processingOrthographic systemBilingual languageLanguage achievementReading paradigmLanguage domainsHebrew sentences
2016
Cannabinoids reverse the effects of early stress on neurocognitive performance in adulthood
Alteba S, Korem N, Akirav I. Cannabinoids reverse the effects of early stress on neurocognitive performance in adulthood. Learning & Memory 2016, 23: 349-358. PMID: 27317195, PMCID: PMC4918780, DOI: 10.1101/lm.041608.116.Peer-Reviewed Original ResearchConceptsEarly life stressLate adolescenceRecognition taskLife stressCannabinoid CB1/2 receptor agonistNovel object recognition taskEffects of ELSSocial recognition taskShort-term memoryCB1/2 receptor agonistObject recognition taskAnxiety-related disordersStress-induced impairmentRecognition memoryFear circuitImpaired performanceNeurocognitive performanceTreatment of stressCognitive deficitsNeurocognitive functionAnxiety levelsCB1 receptorsEarly stressPFC GRSpatial locationThe role of empathy in the neural responses to observed human social touch
Peled-Avron L, Levy-Gigi E, Richter-Levin G, Korem N, Shamay-Tsoory S. The role of empathy in the neural responses to observed human social touch. Cognitive, Affective, & Behavioral Neuroscience 2016, 16: 802-813. PMID: 27165338, DOI: 10.3758/s13415-016-0432-5.Peer-Reviewed Original ResearchConceptsHuman social touchNeural responsesSocial touchEmpathic traitsEmpathic participantsElectrophysiological responsesMore pleasant emotionsRole of empathyGreater mu suppressionLevel of empathyPleasant emotionsSensorimotor resonanceEmotional contagionMu suppressionPersonal distressObserved touchNeural markersTactile stimuliInanimate objectsElectroencephalography (EEG) activityInterindividual differencesEmotionsHuman interactionEmpathyParticipants
2014
Cannabinoids Prevent the Effects of a Footshock Followed by Situational Reminders on Emotional Processing
Korem N, Akirav I. Cannabinoids Prevent the Effects of a Footshock Followed by Situational Reminders on Emotional Processing. Neuropsychopharmacology 2014, 39: 2709-2722. PMID: 24897957, PMCID: PMC4200492, DOI: 10.1038/npp.2014.132.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzoxazinesBrainCannabinoid Receptor AgonistsCannabinoidsCuesDisease Models, AnimalElectroshockEmotionsExtinction, PsychologicalLong-Term PotentiationMaleMorpholinesNaphthalenesNeuronal PlasticityRats, Sprague-DawleyReceptors, CannabinoidReceptors, GlucocorticoidReflex, StartleSpace PerceptionStress Disorders, Post-TraumaticConceptsPosttraumatic stress disorderSituational remindersEmotional processingPrefrontal cortexTrauma exposureTraumatic eventsBasolateral amygdalaPTSD-like symptomsTrajectory of PTSDCB1/2 receptor agonistCB1 receptorsGlucocorticoid receptorImpaired extinctionSingle footshockStress disorderBrain areasFootshockCB1R expressionImpaired plasticityReceptor agonistDay 1Day 3ProcessingCA1Altered expression