Poly(lactic-co-glycolide) polymer constructs cross-linked with human BMP-6 and VEGF protein significantly enhance rat mandible defect repair
Das A, Fishero B, Christophel J, Li C, Kohli N, Lin Y, Dighe A, Cui Q. Poly(lactic-co-glycolide) polymer constructs cross-linked with human BMP-6 and VEGF protein significantly enhance rat mandible defect repair. Cell And Tissue Research 2015, 364: 125-135. PMID: 26475719, DOI: 10.1007/s00441-015-2301-x.Peer-Reviewed Original ResearchConceptsDelivery of vascular endothelial growth factorVascular endothelial growth factorPoly(lactic-co-glycolic acidMesenchymal stem cellsThree-dimensional scaffoldsPoly(lactic-co-glycolideBMP-6Rat mesenchymal stem cellsThermal sinteringDelivery of mesenchymal stem cellsSignificant bone regenerationCombined deliveryVascular endothelial growth factor proteinCritical-size mandibular defectsPLAGA microspheresRecombinant human vascular endothelial growth factorBone repairSprague Dawley ratsEndothelial growth factorBone repair siteHuman vascular endothelial growth factorEnhancement of angiogenesisBone morphogenetic protein 6Bone regenerationDays in vitro