2011
Numerous isoforms of Fgf8 reflect its multiple roles in the developing brain
Sunmonu N, Li K, Li J. Numerous isoforms of Fgf8 reflect its multiple roles in the developing brain. Journal Of Cellular Physiology 2011, 226: 1722-1726. PMID: 21506104, PMCID: PMC3071877, DOI: 10.1002/jcp.22587.Peer-Reviewed Original ResearchConceptsVertebrate developmentDevelopment of multicellular organismsSplice variantsIsoform proteinsIntegration of cell proliferationRNA alternative splicingMouse Fgf8 geneFibroblast growth factorIn vivo functionMulticellular organismsAlternative splicingFate determinationSoluble growth factorsFgf8 geneN-terminiPolypeptide growth factorsGrowth factorFgf8Ligand-receptor systemSplicingVertebratesCell proliferationFunction of FGF8IsoformsProteinGbx2 and Fgf8 are sequentially required for formation of the midbrain-hindbrain compartment boundary
Sunmonu N, Li K, Guo Q, Li J. Gbx2 and Fgf8 are sequentially required for formation of the midbrain-hindbrain compartment boundary. Development 2011, 138: 725-734. PMID: 21266408, PMCID: PMC3026416, DOI: 10.1242/dev.055665.Peer-Reviewed Original ResearchConceptsMidbrain-hindbrain borderCompartment boundariesCell movementLineage boundariesCell-cell signalingPrevents cell movementsCell sortingGenetic inducible fate mappingExpression borderLineage-restriction boundariesCell surface characteristicsCell-autonomous effectsExpression of Otx2Inducible fate mappingFGF pathwayHomeobox genesGbx2Neural plateHindbrain fateFgf8Transverse bandsLineagesMidbrain progenitorsFate mappingHindbrain progenitors
2009
Fgf8b-containing spliceforms, but not Fgf8a, are essential for Fgf8 function during development of the midbrain and cerebellum
Guo Q, Li K, Sunmonu N, Li J. Fgf8b-containing spliceforms, but not Fgf8a, are essential for Fgf8 function during development of the midbrain and cerebellum. Developmental Biology 2009, 338: 183-192. PMID: 19968985, PMCID: PMC2815264, DOI: 10.1016/j.ydbio.2009.11.034.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingAnimalsCerebellumFibroblast Growth Factor 8Fibroblast Growth FactorsMesencephalonMiceMice, KnockoutMutationConceptsGain-of-function studiesMHB regionMutant miceLoss-of-function analysesSplice-site mutationDouble mutant miceLoss of Fgf8In vivo requirementFunction of FGF8Alternative splicingProtein isoformsRegulatory genesActivation of Fgf8Fgf8 geneN-terminiSpliceformsGrowth retardationPostnatal lethalityGenetic backgroundMiceMidbrainFGF17Fgf8aCerebellumPosterior midbrain