2011
Gbx2 and Fgf8 are sequentially required for formation of the midbrain-hindbrain compartment boundary
Sunmonu N, Li K, Guo Q, Li J. Gbx2 and Fgf8 are sequentially required for formation of the midbrain-hindbrain compartment boundary. Development 2011, 138: 725-734. PMID: 21266408, PMCID: PMC3026416, DOI: 10.1242/dev.055665.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineageFibroblast Growth Factor 8Gene DeletionGene Expression Regulation, DevelopmentalHomeodomain ProteinsMesencephalonMiceMice, TransgenicRhombencephalonSignal TransductionConceptsMidbrain-hindbrain borderCompartment boundariesCell movementLineage boundariesCell-cell signalingPrevents cell movementsCell sortingGenetic inducible fate mappingExpression borderLineage-restriction boundariesCell surface characteristicsCell-autonomous effectsExpression of Otx2Inducible fate mappingFGF pathwayHomeobox genesGbx2Neural plateHindbrain fateFgf8Transverse bandsLineagesMidbrain progenitorsFate mappingHindbrain progenitors
2009
Misexpression of Gbx2 throughout the mesencephalon by a conditional gain‐of‐function transgene leads to deletion of the midbrain and cerebellum in mice
Sunmonu N, Chen L, Li J. Misexpression of Gbx2 throughout the mesencephalon by a conditional gain‐of‐function transgene leads to deletion of the midbrain and cerebellum in mice. Genesis 2009, 47: 667-673. PMID: 19603509, PMCID: PMC2783588, DOI: 10.1002/dvg.20546.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebellumGene Expression Regulation, DevelopmentalHomeodomain ProteinsMesencephalonMiceMice, TransgenicTransgenesConceptsTransgenic mouse linesMouse homeobox genesMidbrain-hindbrain junctionCre-mediated recombinationPersistent expressionAbsence of CreEmbryonic dayMouse linesMouse embryosAdult brainExpression of Gbx2MiceAnterior shiftHomeobox genesNeural tubeMidbrainFunctional studiesPosterior partCerebellumRhombomere 1Ectopic expressionMesencephalonOtx2Red fluorescent proteinBeta-galactosidase