Gbx2 and Fgf8 are sequentially required for formation of the midbrain-hindbrain compartment boundary
Sunmonu N, Li K, Guo Q, Li J. Gbx2 and Fgf8 are sequentially required for formation of the midbrain-hindbrain compartment boundary. Development 2011, 138: 725-734. PMID: 21266408, PMCID: PMC3026416, DOI: 10.1242/dev.055665.Peer-Reviewed Original ResearchConceptsMidbrain-hindbrain borderCompartment boundariesCell movementLineage boundariesCell-cell signalingPrevents cell movementsCell sortingGenetic inducible fate mappingExpression borderLineage-restriction boundariesCell surface characteristicsCell-autonomous effectsExpression of Otx2Inducible fate mappingFGF pathwayHomeobox genesGbx2Neural plateHindbrain fateFgf8Transverse bandsLineagesMidbrain progenitorsFate mappingHindbrain progenitors