Misexpression of Gbx2 throughout the mesencephalon by a conditional gain‐of‐function transgene leads to deletion of the midbrain and cerebellum in mice
Sunmonu N, Chen L, Li J. Misexpression of Gbx2 throughout the mesencephalon by a conditional gain‐of‐function transgene leads to deletion of the midbrain and cerebellum in mice. Genesis 2009, 47: 667-673. PMID: 19603509, PMCID: PMC2783588, DOI: 10.1002/dvg.20546.Peer-Reviewed Original ResearchConceptsTransgenic mouse linesMouse homeobox genesMidbrain-hindbrain junctionCre-mediated recombinationPersistent expressionAbsence of CreEmbryonic dayMouse linesMouse embryosAdult brainExpression of Gbx2MiceAnterior shiftHomeobox genesNeural tubeMidbrainFunctional studiesPosterior partCerebellumRhombomere 1Ectopic expressionMesencephalonOtx2Red fluorescent proteinBeta-galactosidase