Fgf8b-containing spliceforms, but not Fgf8a, are essential for Fgf8 function during development of the midbrain and cerebellum
Guo Q, Li K, Sunmonu N, Li J. Fgf8b-containing spliceforms, but not Fgf8a, are essential for Fgf8 function during development of the midbrain and cerebellum. Developmental Biology 2009, 338: 183-192. PMID: 19968985, PMCID: PMC2815264, DOI: 10.1016/j.ydbio.2009.11.034.Peer-Reviewed Original ResearchConceptsGain-of-function studiesMHB regionMutant miceLoss-of-function analysesSplice-site mutationDouble mutant miceLoss of Fgf8In vivo requirementFunction of FGF8Alternative splicingProtein isoformsRegulatory genesActivation of Fgf8Fgf8 geneN-terminiSpliceformsGrowth retardationPostnatal lethalityGenetic backgroundMiceMidbrainFGF17Fgf8aCerebellumPosterior midbrain