2011
Numerous isoforms of Fgf8 reflect its multiple roles in the developing brain
Sunmonu N, Li K, Li J. Numerous isoforms of Fgf8 reflect its multiple roles in the developing brain. Journal Of Cellular Physiology 2011, 226: 1722-1726. PMID: 21506104, PMCID: PMC3071877, DOI: 10.1002/jcp.22587.Peer-Reviewed Original ResearchConceptsVertebrate developmentDevelopment of multicellular organismsSplice variantsIsoform proteinsIntegration of cell proliferationRNA alternative splicingMouse Fgf8 geneFibroblast growth factorIn vivo functionMulticellular organismsAlternative splicingFate determinationSoluble growth factorsFgf8 geneN-terminiPolypeptide growth factorsGrowth factorFgf8Ligand-receptor systemSplicingVertebratesCell proliferationFunction of FGF8IsoformsProtein
2009
Fgf8b-containing spliceforms, but not Fgf8a, are essential for Fgf8 function during development of the midbrain and cerebellum
Guo Q, Li K, Sunmonu N, Li J. Fgf8b-containing spliceforms, but not Fgf8a, are essential for Fgf8 function during development of the midbrain and cerebellum. Developmental Biology 2009, 338: 183-192. PMID: 19968985, PMCID: PMC2815264, DOI: 10.1016/j.ydbio.2009.11.034.Peer-Reviewed Original ResearchConceptsGain-of-function studiesMHB regionMutant miceLoss-of-function analysesSplice-site mutationDouble mutant miceLoss of Fgf8In vivo requirementFunction of FGF8Alternative splicingProtein isoformsRegulatory genesActivation of Fgf8Fgf8 geneN-terminiSpliceformsGrowth retardationPostnatal lethalityGenetic backgroundMiceMidbrainFGF17Fgf8aCerebellumPosterior midbrain