2017
Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus
Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, Vera A, DiLuna ML, Delpire E, Alper SL, Gunel M, Gerzanich V, Medzhitov R, Simard JM, Kahle KT. Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus. Nature Medicine 2017, 23: 997-1003. PMID: 28692063, DOI: 10.1038/nm.4361.Peer-Reviewed Original ResearchMeSH KeywordsAcetazolamideAnimalsAntioxidantsBlotting, WesternBumetanideCerebral HemorrhageCerebral VentriclesCerebrospinal FluidChoroid PlexusDiureticsGene Knockdown TechniquesGene Knockout TechniquesHydrocephalusImmunoblottingImmunohistochemistryImmunoprecipitationInflammationNF-kappa BProlineProtein Serine-Threonine KinasesRatsRats, WistarSalicylanilidesSolute Carrier Family 12, Member 2SulfonamidesThiocarbamatesToll-Like Receptor 4
2010
Stabilization of VEGFR2 Signaling by Cerebral Cavernous Malformation 3 Is Critical for Vascular Development
He Y, Zhang H, Yu L, Gunel M, Boggon TJ, Chen H, Min W. Stabilization of VEGFR2 Signaling by Cerebral Cavernous Malformation 3 Is Critical for Vascular Development. Science Signaling 2010, 3: ra26. PMID: 20371769, PMCID: PMC3052863, DOI: 10.1126/scisignal.2000722.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCardiovascular SystemEndothelial CellsFluorescent Antibody Technique, IndirectGene DeletionGene Expression ProfilingGene Knockdown TechniquesHematopoiesisHumansImmunoblottingImmunohistochemistryImmunoprecipitationMiceReverse Transcriptase Polymerase Chain ReactionSignal TransductionVascular Endothelial Growth Factor Receptor-2ConceptsCarboxyl-terminal domainVascular endothelial growth factor receptor 2Vascular developmentHuman vascular malformationsCerebral cavernous malformation 3Early embryonic stagesCerebral cavernous malformationsEndothelial cell-specific deletionApoptotic stimuliCell-specific deletionVivo functionEmbryonic angiogenesisEndothelial growth factor receptor 2Unknown functionVEGF stimulationVEGFR2 signalingEmbryonic stagesMessenger RNASmooth muscle cellsGrowth factor receptor 2DeletionCCM3 genesFactor receptor 2Muscle cellsGenes
2009
CCM2 and CCM3 proteins contribute to vasculogenesis and angiogenesis in human placenta.
Tanriover G, Seval Y, Sati L, Gunel M, Demir N. CCM2 and CCM3 proteins contribute to vasculogenesis and angiogenesis in human placenta. Histology And Histopathology 2009, 24: 1287-94. PMID: 19688696, DOI: 10.14670/hh-24.1287.Peer-Reviewed Original ResearchMeSH KeywordsApoptosis Regulatory ProteinsCarrier ProteinsCase-Control StudiesCentral Nervous System NeoplasmsFemaleHemangioma, Cavernous, Central Nervous SystemHumansImmunohistochemistryMembrane ProteinsNeovascularization, PathologicPlacentaPregnancyPregnancy Trimester, FirstPregnancy Trimester, ThirdProto-Oncogene ProteinsConceptsCerebral cavernous malformationsVascular endotheliumBlood vessel formationHuman placentaMature intermediate villiVascular malformationsStem villiTerm placentaVessel formationIntermediate villiNormal brain parenchymaMeans of immunohistochemistryCentral nervous systemEndothelium-lined vascular channelsWestern blot analysisEarly pregnancyBrain parenchymaModerate immunostainingCavernous malformationsNervous systemVascular channelsPlacental developmentPlacentaEndotheliumLess expression
2005
CCM2 Expression Parallels That of CCM1
Seker A, Pricola KL, Guclu B, Ozturk AK, Louvi A, Gunel M. CCM2 Expression Parallels That of CCM1. Stroke 2005, 37: 518-523. PMID: 16373645, DOI: 10.1161/01.str.0000198835.49387.25.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternBrainCarrier ProteinsCells, CulturedCentral Nervous SystemCerebral CortexChlorocebus aethiopsCOS CellsEndothelium, VascularHumansImmunohistochemistryIn Situ HybridizationKRIT1 ProteinMiceMicrotubule-Associated ProteinsMuscle, SmoothMutationNeuronsPhenotypeProto-Oncogene ProteinsRNA, MessengerSignal TransductionTime FactorsTwo-Hybrid System TechniquesUmbilical VeinsConceptsCerebral cavernous malformationsProtein expressionExtracerebral tissuesFamilial cerebral cavernous malformationsArterial vascular endotheliumPostnatal mouse brainSmooth muscle cellsVascular wall elementsWestern blot analysisExpression patternsPyramidal neuronsVenous circulationCerebral tissueNeurovascular diseasesCavernous malformationsImmunohistochemical analysisVascular endotheliumMouse brainMRNA expressionMuscle cellsFoot processesEpithelial cellsExpression parallelsDisease phenotypeSpatial expression patternsExpression of Structural Proteins and Angiogenic Factors in Normal Arterial and Unruptured and Ruptured Aneurysm Walls
Kılıc T, Sohrabifar M, Kurtkaya Ö, Yildirim Ö, Elmaci I, Günel M, Pamir MN. Expression of Structural Proteins and Angiogenic Factors in Normal Arterial and Unruptured and Ruptured Aneurysm Walls. Neurosurgery 2005, 57: 997-1007. PMID: 16284569, DOI: 10.1227/01.neu.0000180812.77621.6c.Peer-Reviewed Original ResearchConceptsStructural proteinsGrowth factorPattern of expressionCertain structural proteinsAngiogenic growth factorsLevel of expressionNormal vessel wallGrowth factor alpha expressionAngiogenic factorsProteinBiological mediatorsExpressionFibronectinVessel wallLamininNovel findingsIntracranial aneurysm formationPairs of specimensAneurysmal specimensTissue groupsFormationMediators
1995
Vasoactive intestinal polypeptide and its receptor changes in human temporal lobe epilepsy
de Lanerolle NC, Gunel M, Sundaresan S, Shen MY, Brines ML, Spencer DD. Vasoactive intestinal polypeptide and its receptor changes in human temporal lobe epilepsy. Brain Research 1995, 686: 182-193. PMID: 7583284, DOI: 10.1016/0006-8993(95)00365-w.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyTemporal lobe lesionsLobe epilepsySeizure focusLobe lesionsCA fieldsReceptor distributionHuman hippocampusHuman temporal lobe epilepsyIntractable temporal lobe epilepsyHippocampal seizure focusHippocampal neuronal lossVasoactive intestinal polypeptideDentate molecular layerAutopsy hippocampiVIP immunoreactivityNeuronal lossIntestinal polypeptidePatient groupReceptor autoradiographyReceptor changesTLE patientsIntestinal peptideNeuronal numberAmmon's horn