2021
A Unique Gut Microbiome–Physical Function Axis Exists in Older People with HIV: An Exploratory Study
Dillon SM, Abdo MH, Wilson MP, Liu J, Jankowski CM, Robertson CE, Tuncil Y, Hamaker B, Frank DN, MaWhinney S, Wilson CC, Erlandson KM. A Unique Gut Microbiome–Physical Function Axis Exists in Older People with HIV: An Exploratory Study. AIDS Research And Human Retroviruses 2021, 37: 542-550. PMID: 33787299, PMCID: PMC8260890, DOI: 10.1089/aid.2020.0283.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBody CompositionGastrointestinal MicrobiomeHIV InfectionsHumansInflammationMicrobiotaMiddle AgedConceptsPhysical functionOlder PWHOlder personsMuscle functionLean massLower short physical performance battery scoresBody compositionShort Physical Performance Battery scoreLower extremity muscle functionPhysical Performance Battery scoreGut microbiomeStool SCFA levelsEffective antiretroviral therapyPhysical function measurementsBetter muscle functionFunction axisAntiretroviral therapySCFA levelsHIV serostatusSPPB scoreUninfected personsSCFA butyrateGrip strengthUninfected controlsPWH
2017
Frailty is strongly associated with increased risk of recurrent falls among older HIV-infected adults
Tassiopoulos K, Abdo M, Wu K, Koletar SL, Palella FJ, Kalayjian R, Taiwo B, Erlandson KM. Frailty is strongly associated with increased risk of recurrent falls among older HIV-infected adults. AIDS 2017, 31: 2287-2294. PMID: 28991026, PMCID: PMC5654616, DOI: 10.1097/qad.0000000000001613.Peer-Reviewed Original ResearchMeSH KeywordsAccidental FallsAdultAgedAged, 80 and overFemaleFrailtyHIV InfectionsHumansMaleMiddle AgedProspective StudiesRecurrenceRisk AssessmentConceptsRecurrent fallsFrailty assessmentGrip strengthSelf-reported weight lossLogistic regressionContribution of frailtyMulticenter cohort studyLow physical activityRisk of fallsPotential target populationOlder HIVCohort studyBaseline frailtyPeripheral neuropathyEffect modificationFrail individualsMultivariable modelFrail personsPhysical activityClinical careMultinomial logistic regressionHIVNonfrail individualsPrefrailSignificant association