2021
A Novel Risk Stratification System for Ischemic Stroke in Japanese Patients With Non-Valvular Atrial Fibrillation
Okumura K, Tomita H, Nakai M, Kodani E, Akao M, Suzuki S, Hayashi K, Sawano M, Goya M, Yamashita T, Fukuda K, Ogawa H, Tsuda T, Isobe M, Toyoda K, Miyamoto Y, Miyata H, Okamura T, Sasahara Y, Group F. A Novel Risk Stratification System for Ischemic Stroke in Japanese Patients With Non-Valvular Atrial Fibrillation. Circulation Journal 2021, 85: 1254-1262. PMID: 33762526, DOI: 10.1253/circj.cj-20-1075.Peer-Reviewed Original ResearchConceptsJapanese NVAF patientsIndependent risk factorIschemic strokeNVAF patientsRisk factorsAF RegistryHazard ratioC-statisticJapanese non-valvular atrial fibrillation (NVAF) patientsNon-valvular atrial fibrillation patientsCox hazard proportional analysisNovel risk stratification systemNon-valvular atrial fibrillationLower body mass indexFushimi AF RegistryIschemic stroke eventsJ-RHYTHM RegistryAtrial fibrillation patientsOral anticoagulant treatmentBody mass indexSignificant risk factorsRisk stratification systemType of AFVASc scoreAnticoagulant treatment
2020
Independent and cumulative association of clinical and morphological heart failure with long-term outcome after percutaneous coronary intervention
Kimura M, Kohno T, Sawano M, Heidenreich P, Ueda I, Takahashi T, Matsubara T, Ueno K, Hayashida K, Yuasa S, Ohki T, Fukuda K, Kohsaka S. Independent and cumulative association of clinical and morphological heart failure with long-term outcome after percutaneous coronary intervention. Journal Of Cardiology 2020, 77: 41-47. PMID: 32888830, DOI: 10.1016/j.jjcc.2020.06.014.Peer-Reviewed Original ResearchMeSH KeywordsAgedCause of DeathFemaleHeart Disease Risk FactorsHeart FailureHospitalizationHumansIncidenceJapanMaleMiddle AgedPercutaneous Coronary InterventionPostoperative ComplicationsProportional Hazards ModelsRegistriesStrokeStroke VolumeTreatment OutcomeVentricular Dysfunction, LeftVentricular Function, LeftConceptsLeft ventricular systolic dysfunctionLeft ventricular ejection fractionMajor adverse cardiovascular eventsClinical heart failureNon-cardiac deathHeart failureLong-term outcomesHF hospitalizationIncidence of MACEAdverse long-term clinical outcomesLong-term clinical outcomesPercutaneous coronary intervention outcomesClinical HF symptomsMulticenter registry studyAdverse cardiovascular eventsCoronary artery bypassVentricular systolic dysfunctionAcute coronary syndromePercutaneous coronary interventionVentricular ejection fractionPost-procedural outcomesCause deathArtery bypassCardiovascular eventsCoronary syndromeAssociation of Second-Generation Drug-Eluting Stent Length With 2-Year Adverse Clinical Outcomes Among Japanese Patients With Ischemic Heart Disease
Ejiri K, Sawano M, Numasawa Y, Noma S, Ito H, Fukuda K, Kohsaka S. Association of Second-Generation Drug-Eluting Stent Length With 2-Year Adverse Clinical Outcomes Among Japanese Patients With Ischemic Heart Disease. JAMA Network Open 2020, 3: e2012546. PMID: 32756926, PMCID: PMC7407091, DOI: 10.1001/jamanetworkopen.2020.12546.Peer-Reviewed Original ResearchIschemic and Bleeding Events Among Patients With Acute Coronary Syndrome Associated With Low-Dose Prasugrel vs Standard-Dose Clopidogrel Treatment
Shoji S, Sawano M, Sandhu A, Heidenreich P, Shiraishi Y, Ikemura N, Ueno K, Suzuki M, Numasawa Y, Fukuda K, Kohsaka S. Ischemic and Bleeding Events Among Patients With Acute Coronary Syndrome Associated With Low-Dose Prasugrel vs Standard-Dose Clopidogrel Treatment. JAMA Network Open 2020, 3: e202004. PMID: 32239221, PMCID: PMC7118520, DOI: 10.1001/jamanetworkopen.2020.2004.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAged, 80 and overAspirinBrain IschemiaCase-Control StudiesClopidogrelDeathDrug Therapy, CombinationFemaleHemorrhageHumansJapanMaleMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsPrasugrel HydrochlorideRegistriesRenal Insufficiency, ChronicRetrospective StudiesRisk AssessmentStrokeConceptsLow-dose prasugrelPercutaneous coronary interventionPrimary ischemic eventsAcute coronary syndromeBleeding eventsIschemic eventsCoronary syndromeST-segment elevation myocardial infarctionAcute Coronary Syndrome AssociatedPropensity score-matched analysisHigh-bleeding riskStandard-dose clopidogrelChronic kidney diseaseElevation myocardial infarctionPresent cohort studyShort-term outcomesEast Asian patientsReal-world outcomesPrasugrel treatmentClopidogrel administrationP2Y12 inhibitorsBaseline characteristicsClopidogrel treatmentCohort studyCoronary interventionElectrocardiographic ST-T Abnormities Are Associated With Stroke Risk in the REGARDS Study
Sawano M, Yuan Y, Kohsaka S, Inohara T, Suzuki T, Okamura T, Howard G, Howard V, Judd S, Soliman E, Cushman M. Electrocardiographic ST-T Abnormities Are Associated With Stroke Risk in the REGARDS Study. Stroke 2020, 51: 1100-1106. PMID: 32126939, PMCID: PMC7122793, DOI: 10.1161/strokeaha.119.028069.Peer-Reviewed Original ResearchConceptsIschemic strokeREGARDS studyMultivariable Cox proportional hazards regressionIncident coronary artery diseaseCox proportional hazards regressionAge-adjusted incidence ratesCalculate hazard ratiosFuture ischemic strokeIncident ischemic strokeMinnesota ECG ClassificationStroke risk factorsRisk of strokeCoronary artery diseaseProportional hazards regressionCoronary heart diseaseMinor ECG abnormalitiesNonspecific ST-segmentT-wave abnormalitiesIncident strokePrior strokeArtery diseaseHazard ratioStroke riskHazards regressionBaseline ECG
2018
Stroke After Percutaneous Coronary Intervention in the Era of Transradial Intervention
Shoji S, Kohsaka S, Kumamaru H, Sawano M, Shiraishi Y, Ueda I, Noma S, Suzuki M, Numasawa Y, Hayashida K, Yuasa S, Miyata H, Fukuda K. Stroke After Percutaneous Coronary Intervention in the Era of Transradial Intervention. Circulation Cardiovascular Interventions 2018, 11: e006761. PMID: 30545258, DOI: 10.1161/circinterventions.118.006761.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionPeriprocedural strokeTransradial interventionTransfemoral interventionCoronary interventionAccess siteElective percutaneous coronary interventionPropensity score-matched analysisMultivariable logistic regression analysisOptimal access siteProspective multicenter databaseAcute kidney injuryAcute coronary syndromeChronic kidney diseaseLife-threatening complicationsPeripheral artery diseaseLogistic regression analysisCoronary syndromeHemorrhagic eventsKidney injuryPCI complicationsArtery diseaseMulticenter databaseStroke patientsKidney diseaseThe Case of Dynamic CHA2DS2-VASc Score Beyond Risk Prediction
Sawano M, Kohsaka S, Kimura T, Takatsuki S, Fukuda K. The Case of Dynamic CHA2DS2-VASc Score Beyond Risk Prediction. Journal Of The American College Of Cardiology 2018, 71: 1942. PMID: 29699623, DOI: 10.1016/j.jacc.2018.02.062.Commentaries, Editorials and Letters
2016
Degree of dyspnoea in patients with non‐ST‐elevation acute coronary syndrome: A report from Japanese multicenter registry
Shiraishi Y, Kohsaka S, Ueda I, Inohara T, Sawano M, Numasawa Y, Hayashida K, Maekawa Y, Momiyama Y, Fukuda K. Degree of dyspnoea in patients with non‐ST‐elevation acute coronary syndrome: A report from Japanese multicenter registry. International Journal Of Clinical Practice 2016, 70: 978-987. PMID: 28032431, DOI: 10.1111/ijcp.12905.Peer-Reviewed Original ResearchConceptsAcute heart failureAcute coronary syndromeElevation acute coronary syndromeDegree of dyspnoeaDyspnoea severityRenal eventsMajor cardiovascularHospital mortalityCoronary syndromeNon-ST elevation acute coronary syndromeJapanese multicenter registryMulticenter PCI registryNSTE-ACS patientsRenal event rateMild activityDyspnoeic symptomsNSTE-ACSHospital deathHospital outcomesMulticenter registryPCI registryMultivariate adjustmentConsecutive patientsHeart failureDyspnoea