Featured Publications
Bleeding avoidance strategies and percutaneous coronary intervention outcomes: A 10-year observation from a Japanese Multicenter Registry
Sawano M, Spertus J, Masoudi F, Rumsfeld J, Numasawa Y, Inohara T, Kennedy K, Ueda I, Miyata H, Fukuda K, Kohsaka S. Bleeding avoidance strategies and percutaneous coronary intervention outcomes: A 10-year observation from a Japanese Multicenter Registry. American Heart Journal 2021, 235: 113-124. PMID: 33472053, DOI: 10.1016/j.ahj.2021.01.010.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionTransfemoral approachTransradial approachNational Cardiovascular Data Registry CathPCI RegistryVascular closure device usePercutaneous coronary intervention outcomesMultivariable logistic regression analysisClosure device useConsecutive PCI patientsJapanese multicenter registryAdjusted odds ratioLogistic regression analysisPCI patientsCathPCI RegistryCoronary interventionMulticenter registryBleeding rateJapanese patientsOdds ratioRisk scoreLower riskPatientsUS populationCathPCIJapanese populationPerformance of the MAGGIC heart failure risk score and its modification with the addition of discharge natriuretic peptides
Sawano M, Shiraishi Y, Kohsaka S, Nagai T, Goda A, Mizuno A, Sujino Y, Nagatomo Y, Kohno T, Anzai T, Fukuda K, Yoshikawa T. Performance of the MAGGIC heart failure risk score and its modification with the addition of discharge natriuretic peptides. ESC Heart Failure 2018, 5: 610-619. PMID: 29520978, PMCID: PMC6073038, DOI: 10.1002/ehf2.12278.Peer-Reviewed Original ResearchConceptsMAGGIC scoreBNP levelsB-type natriuretic peptide levelsAcute Heart Failure registryChronic Heart Failure (MAGGIC) scoreConsecutive acute HF patientsHeart failure patient outcomesHeart Failure Risk ScoreMeta-Analysis Global GroupAcute HF patientsHeart Failure RegistryHeart failure scoreProspective multicentre registryIncremental prognostic valueNatriuretic peptide levelsHeart failure patientsMulticentre registryHF patientsFailure patientsYear mortalityNatriuretic peptidePatient mortalityPrognostic valueMean ageJapanese RegistrySex Difference in Outcomes of Acute Myocardial Infarction in Young Patients
Sawano M, Lu Y, Caraballo C, Mahajan S, Dreyer R, Lichtman J, D'Onofrio G, Spatz E, Khera R, Onuma O, Murugiah K, Spertus J, Krumholz H. Sex Difference in Outcomes of Acute Myocardial Infarction in Young Patients. Journal Of The American College Of Cardiology 2023, 81: 1797-1806. PMID: 37137590, DOI: 10.1016/j.jacc.2023.03.383.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHealth StatusHospitalizationHumansMaleMyocardial InfarctionRisk FactorsSex CharacteristicsSex FactorsConceptsAcute myocardial infarctionNoncardiac hospitalizationsSubdistribution HRYounger patientsMyocardial infarctionSex differencesYoung womenCause-specific hospitalizationsCause of hospitalizationWorse health statusSignificant sex disparityNoncardiovascular hospitalizationsVIRGO StudyIndex episodeAdverse outcomesIncidence rateHospitalizationHigh riskSex disparitiesHealth statusPatientsU.S. hospitalsWomenInfarctionOutcomes
2023
Long-term outcomes of periprocedural coronary dissection and perforation for patients undergoing percutaneous coronary intervention in a Japanese multicenter registry
Kuno T, Ohata T, Nakamaru R, Sawano M, Kodaira M, Numasawa Y, Ueda I, Suzuki M, Noma S, Fukuda K, Kohsaka S. Long-term outcomes of periprocedural coronary dissection and perforation for patients undergoing percutaneous coronary intervention in a Japanese multicenter registry. Scientific Reports 2023, 13: 20318. PMID: 37985895, PMCID: PMC10662469, DOI: 10.1038/s41598-023-47444-7.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionLong-term outcomesCoronary dissectionPrimary endpointCoronary perforationCoronary interventionHeart failurePrimary outcomeMultivariable Cox hazards regression modelIndex percutaneous coronary interventionCox hazard regression modelPoor long-term outcomesIatrogenic coronary dissectionJapanese multicenter registryMulticenter prospective registryCoronary artery bypassAcute coronary syndromeHeart failure readmissionContrast medium extravasationHazards regression modelsPersistent filling defectSignificant differencesHigh rateCause deathArtery bypassIschemic and Bleeding Outcomes in Patients Who Underwent Percutaneous Coronary Intervention With Chronic Kidney Disease or Dialysis (from a Japanese Nationwide Registry)
Tobe A, Sawano M, Kohsaka S, Ishii H, Tanaka A, Numasawa Y, Amano T, Nakamura M, Ikari Y, Murohara T. Ischemic and Bleeding Outcomes in Patients Who Underwent Percutaneous Coronary Intervention With Chronic Kidney Disease or Dialysis (from a Japanese Nationwide Registry). The American Journal Of Cardiology 2023, 195: 37-44. PMID: 37004333, DOI: 10.1016/j.amjcard.2023.02.027.Peer-Reviewed Original ResearchConceptsChronic kidney diseasePercutaneous coronary interventionPresence of CKDCKD stages 1Ischemic eventsAdjustment of covariatesHigh riskPCI registryCoronary interventionKidney diseaseNew-generation drug-eluting stent implantationDrug-eluting stent implantationUnderwent Percutaneous Coronary InterventionCKD stage 3Stage 1Bleeding eventsBleeding outcomesDialysis groupOral anticoagulantsCKD 3Renal functionStent implantationIncidence ratePatientsCare delivery
2022
Machine learning models for prediction of adverse events after percutaneous coronary intervention
Niimi N, Shiraishi Y, Sawano M, Ikemura N, Inohara T, Ueda I, Fukuda K, Kohsaka S. Machine learning models for prediction of adverse events after percutaneous coronary intervention. Scientific Reports 2022, 12: 6262. PMID: 35428765, PMCID: PMC9012739, DOI: 10.1038/s41598-022-10346-1.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAdverse eventsRisk scoreHospital mortalityCoronary interventionConsecutive coronary artery disease patientsCoronary artery disease patientsAdverse periprocedural eventsLow-risk patientsMajor adverse eventsGood discriminationMulticenter registryPeriprocedural eventsDisease patientsClinical decisionLogistic regressionSpecific interventionsRisk predictionOverall risk predictionPatientsScoresInterventionMortalityAdequate discriminationOutcomesJapanese Nationwide PCI (J-PCI) Registry Annual Report 2019: patient demographics and in-hospital outcomes
Ando H, Yamaji K, Kohsaka S, Ishii H, Wada H, Yamada S, Sawano M, Inohara T, Numasawa Y, Ikari Y, Amano T. Japanese Nationwide PCI (J-PCI) Registry Annual Report 2019: patient demographics and in-hospital outcomes. Cardiovascular Intervention And Therapeutics 2022, 37: 243-247. PMID: 35020153, PMCID: PMC8753025, DOI: 10.1007/s12928-021-00832-0.Peer-Reviewed Original ResearchOne-year outcome after percutaneous coronary intervention in nonagenarians: Insights from the J-PCI OUTCOME registry
Otowa K, Kohsaka S, Sawano M, Matsuura S, Chikata A, Maruyama M, Usuda K, Watanabe T, Ishii H, Amano T, Nakamura M, Ikari Y. One-year outcome after percutaneous coronary intervention in nonagenarians: Insights from the J-PCI OUTCOME registry. American Heart Journal 2022, 246: 105-116. PMID: 35016854, DOI: 10.1016/j.ahj.2022.01.004.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAdverse cardiovascular eventsLong-term outcomesCardiovascular eventsNonagenarian patientsCardiovascular mortalityCoronary interventionOutcomes RegistryMajor adverse cardiovascular eventsCV death rateMajor bleeding eventsOne-year outcomesNationwide registration systemPatient-level dataLong-term survivalYears of ageMultivariate regression analysisBleeding eventsCardiogenic shockMajor bleedingOral anticoagulantsAdverse eventsElder patientsCardiac arrestLesion characteristics
2021
Serum modified high-density lipoprotein and risk of atherosclerotic cardiovascular disease in a Japanese community-based nested case–control study
Sata M, Kakino A, Hirata A, Iida M, Usami Y, Harada S, Fujita Y, Kohsaka S, Izawa Y, Sawano M, Oki K, Sugiyama D, Takahashi S, Takebayashi T, Sawamura T, Okamura T. Serum modified high-density lipoprotein and risk of atherosclerotic cardiovascular disease in a Japanese community-based nested case–control study. European Journal Of Preventive Cardiology 2021, 29: e193-e195. PMID: 34472612, DOI: 10.1093/eurjpc/zwab142.Peer-Reviewed Original ResearchEvidence‐to‐Practice Gap for Preventing Procedure‐Related Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Intervention
Shoji S, Sawano M, Sandhu A, Heidenreich P, Shiraishi Y, Noma S, Suzuki M, Numasawa Y, Fukuda K, Kohsaka S. Evidence‐to‐Practice Gap for Preventing Procedure‐Related Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Intervention. Journal Of The American Heart Association 2021, 10: e020047. PMID: 34310187, PMCID: PMC8475676, DOI: 10.1161/jaha.120.020047.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAged, 80 and overClinical Decision-MakingContrast MediaDatabases, FactualEvidence-Based MedicineFemaleHumansIncidenceJapanKidneyKidney Function TestsMaleMiddle AgedPercutaneous Coronary InterventionProfessional Practice GapsProtective FactorsQuality ImprovementQuality Indicators, Health CareRadiography, InterventionalRetrospective StudiesRisk AssessmentRisk FactorsTreatment OutcomeConceptsAcute kidney injuryPercutaneous coronary interventionAKI risk scoreBaseline renal functionContrast volumeCoronary interventionRisk scoreAKI riskKidney injuryRenal functionAcute coronary syndrome presentationBackground Acute kidney injuryIntra-aortic balloon pumpMultivariable linear regression analysisContrast volume usagePreprocedural risk assessmentChronic kidney diseaseAvailable risk scoresCommon complicationBalloon pumpHeart failureSusceptible patientsOverall incidenceSyndrome presentationKidney diseaseA Novel Risk Stratification System for Ischemic Stroke in Japanese Patients With Non-Valvular Atrial Fibrillation
Okumura K, Tomita H, Nakai M, Kodani E, Akao M, Suzuki S, Hayashi K, Sawano M, Goya M, Yamashita T, Fukuda K, Ogawa H, Tsuda T, Isobe M, Toyoda K, Miyamoto Y, Miyata H, Okamura T, Sasahara Y, Group F. A Novel Risk Stratification System for Ischemic Stroke in Japanese Patients With Non-Valvular Atrial Fibrillation. Circulation Journal 2021, 85: 1254-1262. PMID: 33762526, DOI: 10.1253/circj.cj-20-1075.Peer-Reviewed Original ResearchConceptsJapanese NVAF patientsIndependent risk factorIschemic strokeNVAF patientsRisk factorsAF RegistryHazard ratioC-statisticJapanese non-valvular atrial fibrillation (NVAF) patientsNon-valvular atrial fibrillation patientsCox hazard proportional analysisNovel risk stratification systemNon-valvular atrial fibrillationLower body mass indexFushimi AF RegistryIschemic stroke eventsJ-RHYTHM RegistryAtrial fibrillation patientsOral anticoagulant treatmentBody mass indexSignificant risk factorsRisk stratification systemType of AFVASc scoreAnticoagulant treatment
2020
Beta blockers versus calcium channel blockers for provocation of vasospastic angina after drug-eluting stent implantation: a multicentre prospective randomised trial
Sawano M, Katsuki T, Kitai T, Tamita K, Obunai K, Ikegami Y, Yamane T, Ueda I, Endo A, Maekawa Y, Kawamura A, Fukuda K, Kohsaka S. Beta blockers versus calcium channel blockers for provocation of vasospastic angina after drug-eluting stent implantation: a multicentre prospective randomised trial. Open Heart 2020, 7: e001406. PMID: 33087441, PMCID: PMC7580072, DOI: 10.1136/openhrt-2020-001406.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAged, 80 and overAngina PectorisCalcium Channel BlockersCoronary Artery DiseaseCoronary VasospasmDrug-Eluting StentsFemaleHumansIncidenceJapanMaleMiddle AgedPercutaneous Coronary InterventionProspective StudiesProtective FactorsRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsMajor cardiovascular eventsPercutaneous coronary interventionCalcium channel blockersCoronary artery diseaseStable coronary artery diseaseDrug-eluting stent implantationAcetylcholine provocation testingDiagnostic coronary angiographyBeta blockersCCB groupArtery diseaseCoronary angiographyVasospastic anginaCoronary revascularisationProvocation testingStent implantationChannel blockersSecond-generation drug-eluting stent implantationUniversity Hospital Medical Information Network Clinical Trials RegistryIndex percutaneous coronary interventionNon-fatal myocardial infarctionSingle-vessel lesionsSubsequent coronary eventsCoronary artery spasmClinical Trials RegistryAssociation of decreasing hemoglobin levels with the incidence of acute kidney injury after percutaneous coronary intervention: a prospective multi-center study
Kuno T, Numasawa Y, Mikami T, Niimi N, Sawano M, Kodaira M, Suzuki M, Ueno K, Ueda I, Fukuda K, Kohsaka S. Association of decreasing hemoglobin levels with the incidence of acute kidney injury after percutaneous coronary intervention: a prospective multi-center study. Heart And Vessels 2020, 36: 330-336. PMID: 33034713, DOI: 10.1007/s00380-020-01706-w.Peer-Reviewed Original ResearchConceptsAcute kidney injuryPercutaneous coronary interventionRisk of AKIHemoglobin dropAKI incidenceKidney injuryCoronary interventionHemoglobin levelsProspective multi-center studySerum creatinine levelsMulti-center studyRelative decreaseConsecutive patientsCreatinine levelsIndependent predictorsRisk factorsHemoglobin changeHigh riskAbsolute decreaseLogistic regressionPatientsIncidenceHemoglobinInjuryDlRisk Factors Associated With Ischemic Stroke in Japanese Patients With Nonvalvular Atrial Fibrillation
Okumura K, Tomita H, Nakai M, Kodani E, Akao M, Suzuki S, Hayashi K, Sawano M, Goya M, Yamashita T, Fukuda K, Ogawa H, Tsuda T, Isobe M, Toyoda K, Miyamoto Y, Miyata H, Okamura T, Sasahara Y. Risk Factors Associated With Ischemic Stroke in Japanese Patients With Nonvalvular Atrial Fibrillation. JAMA Network Open 2020, 3: e202881. PMID: 32293685, PMCID: PMC7160687, DOI: 10.1001/jamanetworkopen.2020.2881.Peer-Reviewed Original ResearchConceptsNonvalvular atrial fibrillationFushimi AF RegistryJ-RHYTHM RegistryRisk stratification schemesIschemic strokeAF RegistryBody mass indexRisk factorsAtrial fibrillationJapanese patientsPermanent AFPrevious strokeMass indexShinken DatabaseStratification schemesCox proportional hazards analysisLower body mass indexOral anticoagulant useIndependent risk factorProportional hazards analysisSignificant risk factorsIndividual patient dataValvular AFAnticoagulant useCohort studyElectrocardiographic Left Atrial Abnormality and B-Type Natriuretic Peptide in a General Japanese Population: NIPPON DATA2010
Shoji S, Kohsaka S, Sawano M, Okamura T, Hirata A, Sugiyama D, Ohkubo T, Nakamura Y, Watanabe M, Kadota A, Ueshima H, Okayama A, Miura K, Group F. Electrocardiographic Left Atrial Abnormality and B-Type Natriuretic Peptide in a General Japanese Population: NIPPON DATA2010. Journal Of Atherosclerosis And Thrombosis 2020, 28: 34-43. PMID: 32188793, PMCID: PMC7875149, DOI: 10.5551/jat.54171.Peer-Reviewed Original ResearchConceptsFuture cardiovascular eventsBNP concentrationsCardiovascular eventsElevated BNPGeneral populationB-type natriuretic peptide concentrationsElectrocardiographic Left Atrial AbnormalityJapanese Circulation Society guidelinesB-type natriuretic peptideP-wave terminal forceContemporary general populationEarliest detectable markerElevated BNP concentrationsHistory of hypertensionNatriuretic peptide concentrationsJapanese populationGeneral population cohortHigher BNP concentrationsRepresentative Japanese populationGeneral Japanese populationLeft atrial abnormalityAtrial pressureElectrocardiogram (ECG) markersElectrocardiographic findingsNatriuretic peptidePrediction of sudden cardiac death in Japanese heart failure patients: international validation of the Seattle Proportional Risk Model.
Fukuoka R, Kohno T, Kohsaka S, Shiraishi Y, Sawano M, Abe T, Nagatomo Y, Goda A, Mizuno A, Fukuda K, Shadman R, Dardas T, Levy W, Yoshikawa T. Prediction of sudden cardiac death in Japanese heart failure patients: international validation of the Seattle Proportional Risk Model. EP Europace 2020, 22: 588-597. PMID: 32155253, DOI: 10.1093/europace/euaa002.Peer-Reviewed Original ResearchMeSH KeywordsDeath, Sudden, CardiacDefibrillators, ImplantableHeart FailureHumansJapanRisk FactorsTokyoConceptsSeattle Proportional Risk ModelSudden cardiac deathHF patientsProportional risk modelCardiac deathHeart failureIncidence of SCDJapanese heart failure patientsAcute HF patientsICD eligibility criteriaReduced ejection fractionHeart failure patientsHosmer-Lemeshow statisticHF registryAcute decompensationCumulative incidenceFailure patientsEjection fractionC-statisticJapanese RegistryJapanese patientsC-indexSCD predictionEligibility criteriaPatientsElectrocardiographic ST-T Abnormities Are Associated With Stroke Risk in the REGARDS Study
Sawano M, Yuan Y, Kohsaka S, Inohara T, Suzuki T, Okamura T, Howard G, Howard V, Judd S, Soliman E, Cushman M. Electrocardiographic ST-T Abnormities Are Associated With Stroke Risk in the REGARDS Study. Stroke 2020, 51: 1100-1106. PMID: 32126939, PMCID: PMC7122793, DOI: 10.1161/strokeaha.119.028069.Peer-Reviewed Original ResearchConceptsIschemic strokeREGARDS studyMultivariable Cox proportional hazards regressionIncident coronary artery diseaseCox proportional hazards regressionAge-adjusted incidence ratesCalculate hazard ratiosFuture ischemic strokeIncident ischemic strokeMinnesota ECG ClassificationStroke risk factorsRisk of strokeCoronary artery diseaseProportional hazards regressionCoronary heart diseaseMinor ECG abnormalitiesNonspecific ST-segmentT-wave abnormalitiesIncident strokePrior strokeArtery diseaseHazard ratioStroke riskHazards regressionBaseline ECGTransradial Percutaneous Coronary Intervention in Patients With Advanced Chronic Kidney Disease
Yashima F, Inohara T, Numasawa Y, Kuno T, Sawano M, Ueno K, Shimoji K, Noma S, Fukuda K, Kohsaka S. Transradial Percutaneous Coronary Intervention in Patients With Advanced Chronic Kidney Disease. Cardiovascular Revascularization Medicine 2020, 21: 1138-1143. PMID: 32089511, DOI: 10.1016/j.carrev.2020.02.004.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionTransradial interventionTransfemoral interventionAdvanced CKDCKD patientsHemodialysis initiationPCI patientsCoronary interventionPropensity matchingAdvanced chronic kidney diseaseMore procedure-related complicationsChronic kidney disease patientsTransradial percutaneous coronary interventionConsecutive PCI patientsMulticenter Japanese registryAcute kidney injuryChronic kidney diseaseProcedure-related complicationsGlomerular filtration rateKidney disease patientsOutcomes of interestAKI riskKidney injuryClinical outcomesPeriprocedural bleeding
2019
Outcomes of acute coronary syndrome patients with concurrent extra-cardiac vascular disease in the era of transradial coronary intervention: A retrospective multicenter cohort study
Kodaira M, Sawano M, Kuno T, Numasawa Y, Noma S, Suzuki M, Imaeda S, Ueda I, Fukuda K, Kohsaka S. Outcomes of acute coronary syndrome patients with concurrent extra-cardiac vascular disease in the era of transradial coronary intervention: A retrospective multicenter cohort study. PLOS ONE 2019, 14: e0223215. PMID: 31618228, PMCID: PMC6795465, DOI: 10.1371/journal.pone.0223215.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAged, 80 and overCerebrovascular DisordersFemaleHospital MortalityHumansIncidenceMaleMiddle AgedPercutaneous Coronary InterventionPeripheral Vascular DiseasesPostoperative HemorrhageRadial ArteryRegistriesRetrospective StudiesRisk FactorsSeverity of Illness IndexTreatment OutcomeConceptsTransradial coronary interventionAcute coronary syndromePeripheral arterial diseaseCerebrovascular diseaseCoronary interventionVascular diseaseRetrospective multicenter cohort studyAcute coronary syndrome patientsPercutaneous coronary intervention registryMulticenter cohort studyCoronary syndrome patientsCoronary Intervention RegistryIncidence of deathCoronary syndromeCohort studyIntervention RegistryArterial diseaseAdverse outcomesRisk factorsPatient outcomesAccess siteSyndrome patientsHigh riskComplicationsPatientsComparison of Outcomes After Percutaneous Coronary Intervention in Elderly Patients, Including 10 628 Nonagenarians: Insights From a Japanese Nationwide Registry (J‐PCI Registry)
Numasawa Y, Inohara T, Ishii H, Yamaji K, Kohsaka S, Sawano M, Kodaira M, Uemura S, Kadota K, Amano T, Nakamura M, Kadota K, Shiode N, Tanaka N, Amano T, Uemura S, Akasaka T, Morino Y, Fujii K, Hikichi H, Kohsaka S, Ishii H, Tanabe K, Ozaki Y, Sumitsuji S, Iida O, Hara H, Takashima H, Shirai S, Nanasato M, Inohara T, Ueda Y, Numasawa Y, Noma S. Comparison of Outcomes After Percutaneous Coronary Intervention in Elderly Patients, Including 10 628 Nonagenarians: Insights From a Japanese Nationwide Registry (J‐PCI Registry). Journal Of The American Heart Association 2019, 8: e011183. PMID: 30791799, PMCID: PMC6474917, DOI: 10.1161/jaha.118.011017.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAcute coronary syndromeOlder patientsHospital mortalityElderly patientsCoronary interventionNationwide registryYounger patientsTransradial interventionStable coronary artery diseaseConclusion Older patientsJapanese nationwide registryProspective nationwide registryChronic kidney diseaseCoronary artery diseaseComparison of outcomesYears of ageCardiac tamponadeCardiogenic shockCoronary syndromeHospital deathHospital outcomesPeriprocedural complicationsArtery diseaseBlood transfusion