2023
Transradial intervention in dialysis patients undergoing percutaneous coronary intervention: a Japanese nationwide registry study
Kuno T, Yamaji K, Aikawa T, Sawano M, Ando T, Numasawa Y, Wada H, Amano T, Kozuma K, Kohsaka S. Transradial intervention in dialysis patients undergoing percutaneous coronary intervention: a Japanese nationwide registry study. European Heart Journal Open 2023, 3: oead116. PMID: 38105921, PMCID: PMC10721448, DOI: 10.1093/ehjopen/oead116.Peer-Reviewed Original ResearchPercutaneous coronary interventionAccess site bleedingTransradial interventionHospital deathTransfemoral interventionPeriprocedural complicationsSite bleedingCoronary interventionDialysis patientsAccess siteLower riskNationwide registry studyChronic coronary syndromeHospital complicationsCoronary syndromeRegistry studySecondary outcomesPrimary outcomePatient populationBleeding rateRegistry dataComplicationsPatientsTRI groupDialysisGender Differences in Long-Term Outcomes of Young Patients Who Underwent Percutaneous Coronary Intervention: Long-Term Outcome Analysis from a Multicenter Registry in Japan
Kuno T, Miyamoto Y, Sawano M, Kodaira M, Numasawa Y, Ueda I, Suzuki M, Noma S, Fukuda K, Kohsaka S. Gender Differences in Long-Term Outcomes of Young Patients Who Underwent Percutaneous Coronary Intervention: Long-Term Outcome Analysis from a Multicenter Registry in Japan. The American Journal Of Cardiology 2023, 206: 151-160. PMID: 37703680, DOI: 10.1016/j.amjcard.2023.08.106.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionPrimary end pointLong-term outcomesYounger patientsCause deathCoronary interventionOlder patientsMale patientsAcute coronary syndrome casesPrimary end point ratesLong-term outcome analysisST-elevation myocardial infarctionEnd pointUnderwent Percutaneous Coronary InterventionWorse long-term outcomesYoung womenCoronary artery bypassAcute coronary syndromeConsecutive young patientsYoung female patientProportion of smokingNoncardiac deathArtery bypassCoronary syndromeMulticenter registry
2021
Female sex as an independent predictor of high bleeding risk among East Asian percutaneous coronary intervention patients: A sex difference analysis
Kodaira M, Sawano M, Tanaka M, Kuno T, Numasawa Y, Ueda I, Fukuda K, Kohsaka S. Female sex as an independent predictor of high bleeding risk among East Asian percutaneous coronary intervention patients: A sex difference analysis. Journal Of Cardiology 2021, 78: 431-438. PMID: 34172350, DOI: 10.1016/j.jjcc.2021.05.016.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAcute coronary syndromeFine-Gray modelPrimary outcomeFemale sexPercutaneous coronary intervention patientsLower body mass indexEtiology of readmissionMulticenter PCI registryPrevious heart failureUnadjusted readmission ratesAdjusted hazard ratioHigh bleeding riskBody mass indexLong-term outcomesCox regression modelACS survivorsCumulative incidence functionMajor bleedingMore comorbiditiesBleeding riskCoronary syndromeIntervention patientsPCI registryCoronary interventionContemporary Management of Stable Coronary Artery Disease ― Implications of the ISCHEMIA Trial ―
Kohsaka S, Fukushima K, Watanabe I, Manabe S, Niimi N, Gatate Y, Sawano M, Nakano S. Contemporary Management of Stable Coronary Artery Disease ― Implications of the ISCHEMIA Trial ―. Circulation Journal 2021, 85: 1919-1927. PMID: 34148929, DOI: 10.1253/circj.cj-21-0345.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseAcute coronary syndromeStable coronary artery diseaseRecent large-scale clinical trialsLarge-scale clinical trialsCornerstone of managementInvasive coronary angiographyDifferent clinical entitiesUrgent revascularizationCoronary syndromeArtery diseaseCoronary angiographyMedical therapyISCHEMIA trialClinical entityClinical trialsDiagnostic pathwayLeading causePretest probabilityContemporary managementOptimal timingRevascularizationTrialsDisease implicationsMorbidity
2020
Independent and cumulative association of clinical and morphological heart failure with long-term outcome after percutaneous coronary intervention
Kimura M, Kohno T, Sawano M, Heidenreich P, Ueda I, Takahashi T, Matsubara T, Ueno K, Hayashida K, Yuasa S, Ohki T, Fukuda K, Kohsaka S. Independent and cumulative association of clinical and morphological heart failure with long-term outcome after percutaneous coronary intervention. Journal Of Cardiology 2020, 77: 41-47. PMID: 32888830, DOI: 10.1016/j.jjcc.2020.06.014.Peer-Reviewed Original ResearchMeSH KeywordsAgedCause of DeathFemaleHeart Disease Risk FactorsHeart FailureHospitalizationHumansIncidenceJapanMaleMiddle AgedPercutaneous Coronary InterventionPostoperative ComplicationsProportional Hazards ModelsRegistriesStrokeStroke VolumeTreatment OutcomeVentricular Dysfunction, LeftVentricular Function, LeftConceptsLeft ventricular systolic dysfunctionLeft ventricular ejection fractionMajor adverse cardiovascular eventsClinical heart failureNon-cardiac deathHeart failureLong-term outcomesHF hospitalizationIncidence of MACEAdverse long-term clinical outcomesLong-term clinical outcomesPercutaneous coronary intervention outcomesClinical HF symptomsMulticenter registry studyAdverse cardiovascular eventsCoronary artery bypassVentricular systolic dysfunctionAcute coronary syndromePercutaneous coronary interventionVentricular ejection fractionPost-procedural outcomesCause deathArtery bypassCardiovascular eventsCoronary syndromeAntithrombotic Strategy for Patients with Acute Coronary Syndrome: A Perspective from East Asia
Numasawa Y, Sawano M, Fukuoka R, Ejiri K, Kuno T, Shoji S, Kohsaka S. Antithrombotic Strategy for Patients with Acute Coronary Syndrome: A Perspective from East Asia. Journal Of Clinical Medicine 2020, 9: 1963. PMID: 32585929, PMCID: PMC7356748, DOI: 10.3390/jcm9061963.Peer-Reviewed Original ResearchAcute coronary syndromeDual antiplatelet therapyComposite ischemic eventsNovel P2Y12 inhibitorsAntithrombotic strategiesP2Y12 inhibitorsCoronary syndromeIschemic eventsWestern patientsTreatment platelet reactivityUse of clopidogrelPercutaneous coronary interventionCurrent clinical guidelinesStandard of careEast Asian patientsBorderline statistical differenceAntiplatelet therapyAntithrombotic therapyCoronary interventionClinical outcomesPlatelet reactivityAsian patientsHemorrhagic diathesisClinical guidelinesClinical studiesExploring Triaging and Short-Term Outcomes of Early Invasive Strategy in Non-ST Segment Elevation Acute Coronary Syndrome: A Report from Japanese Multicenter Registry
Ikemura N, Shiraishi Y, Sawano M, Ueda I, Numasawa Y, Noma S, Suzuki M, Momiyama Y, Hayashida K, Yuasa S, Miyata H, Fukuda K, Kohsaka S. Exploring Triaging and Short-Term Outcomes of Early Invasive Strategy in Non-ST Segment Elevation Acute Coronary Syndrome: A Report from Japanese Multicenter Registry. Journal Of Clinical Medicine 2020, 9: 1106. PMID: 32294905, PMCID: PMC7230808, DOI: 10.3390/jcm9041106.Peer-Reviewed Original ResearchElevation acute coronary syndromeAcute kidney injuryAcute coronary syndromeHospital mortalityCoronary syndromeMortality riskRisk scoreNon-ST segment elevation acute coronary syndromesNon-ST elevation acute coronary syndromeSegment elevation acute coronary syndromesMultivariable logistic regression analysisJapanese multicenter registryMulticenter Japanese registryEarly invasive strategyChronic kidney diseasePeripheral artery diseaseHospital mortality riskPercutaneous coronary interventionShort-term outcomesRisk-benefit profileLower mortality riskLogistic regression analysisNSTE-ACSKidney injuryMulticenter registryIschemic and Bleeding Events Among Patients With Acute Coronary Syndrome Associated With Low-Dose Prasugrel vs Standard-Dose Clopidogrel Treatment
Shoji S, Sawano M, Sandhu A, Heidenreich P, Shiraishi Y, Ikemura N, Ueno K, Suzuki M, Numasawa Y, Fukuda K, Kohsaka S. Ischemic and Bleeding Events Among Patients With Acute Coronary Syndrome Associated With Low-Dose Prasugrel vs Standard-Dose Clopidogrel Treatment. JAMA Network Open 2020, 3: e202004. PMID: 32239221, PMCID: PMC7118520, DOI: 10.1001/jamanetworkopen.2020.2004.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAged, 80 and overAspirinBrain IschemiaCase-Control StudiesClopidogrelDeathDrug Therapy, CombinationFemaleHemorrhageHumansJapanMaleMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsPrasugrel HydrochlorideRegistriesRenal Insufficiency, ChronicRetrospective StudiesRisk AssessmentStrokeConceptsLow-dose prasugrelPercutaneous coronary interventionPrimary ischemic eventsAcute coronary syndromeBleeding eventsIschemic eventsCoronary syndromeST-segment elevation myocardial infarctionAcute Coronary Syndrome AssociatedPropensity score-matched analysisHigh-bleeding riskStandard-dose clopidogrelChronic kidney diseaseElevation myocardial infarctionPresent cohort studyShort-term outcomesEast Asian patientsReal-world outcomesPrasugrel treatmentClopidogrel administrationP2Y12 inhibitorsBaseline characteristicsClopidogrel treatmentCohort studyCoronary intervention
2019
In-hospital outcome in patients presenting with acute coronary syndrome with left main coronary artery disease: A report from Japanese prospective multicenter percutaneous coronary intervention registry
Tani H, Sawano M, Numasawa Y, Kobayashi Y, Suzuki M, Noma S, Shiraishi Y, Ueda I, Fukuda K, Kohsaka S. In-hospital outcome in patients presenting with acute coronary syndrome with left main coronary artery disease: A report from Japanese prospective multicenter percutaneous coronary intervention registry. Journal Of Cardiology 2019, 75: 635-640. PMID: 31899113, DOI: 10.1016/j.jjcc.2019.11.006.Peer-Reviewed Original ResearchConceptsAcute coronary syndromePercutaneous coronary interventionCardiogenic shockMortality rateACS patientsHospital mortalityCoronary syndromeHospital outcomesHigh riskLeft main coronary artery diseaseMain coronary artery diseasePresence of CSST-elevation myocardial infarctionPercutaneous coronary intervention registryContemporary risk modelsCoronary lesion characteristicsLeft main diseaseCoronary artery bypassHospital mortality rateDe novo patientsElevation myocardial infarctionCoronary artery diseaseCoronary Intervention RegistryShort-term outcomesKey clinical characteristicsOutcomes of acute coronary syndrome patients with concurrent extra-cardiac vascular disease in the era of transradial coronary intervention: A retrospective multicenter cohort study
Kodaira M, Sawano M, Kuno T, Numasawa Y, Noma S, Suzuki M, Imaeda S, Ueda I, Fukuda K, Kohsaka S. Outcomes of acute coronary syndrome patients with concurrent extra-cardiac vascular disease in the era of transradial coronary intervention: A retrospective multicenter cohort study. PLOS ONE 2019, 14: e0223215. PMID: 31618228, PMCID: PMC6795465, DOI: 10.1371/journal.pone.0223215.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAged, 80 and overCerebrovascular DisordersFemaleHospital MortalityHumansIncidenceMaleMiddle AgedPercutaneous Coronary InterventionPeripheral Vascular DiseasesPostoperative HemorrhageRadial ArteryRegistriesRetrospective StudiesRisk FactorsSeverity of Illness IndexTreatment OutcomeConceptsTransradial coronary interventionAcute coronary syndromePeripheral arterial diseaseCerebrovascular diseaseCoronary interventionVascular diseaseRetrospective multicenter cohort studyAcute coronary syndrome patientsPercutaneous coronary intervention registryMulticenter cohort studyCoronary syndrome patientsCoronary Intervention RegistryIncidence of deathCoronary syndromeCohort studyIntervention RegistryArterial diseaseAdverse outcomesRisk factorsPatient outcomesAccess siteSyndrome patientsHigh riskComplicationsPatientsComparison of Outcomes After Percutaneous Coronary Intervention in Elderly Patients, Including 10 628 Nonagenarians: Insights From a Japanese Nationwide Registry (J‐PCI Registry)
Numasawa Y, Inohara T, Ishii H, Yamaji K, Kohsaka S, Sawano M, Kodaira M, Uemura S, Kadota K, Amano T, Nakamura M, Kadota K, Shiode N, Tanaka N, Amano T, Uemura S, Akasaka T, Morino Y, Fujii K, Hikichi H, Kohsaka S, Ishii H, Tanabe K, Ozaki Y, Sumitsuji S, Iida O, Hara H, Takashima H, Shirai S, Nanasato M, Inohara T, Ueda Y, Numasawa Y, Noma S. Comparison of Outcomes After Percutaneous Coronary Intervention in Elderly Patients, Including 10 628 Nonagenarians: Insights From a Japanese Nationwide Registry (J‐PCI Registry). Journal Of The American Heart Association 2019, 8: e011183. PMID: 30791799, PMCID: PMC6474917, DOI: 10.1161/jaha.118.011017.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAcute coronary syndromeOlder patientsHospital mortalityElderly patientsCoronary interventionNationwide registryYounger patientsTransradial interventionStable coronary artery diseaseConclusion Older patientsJapanese nationwide registryProspective nationwide registryChronic kidney diseaseCoronary artery diseaseComparison of outcomesYears of ageCardiac tamponadeCardiogenic shockCoronary syndromeHospital deathHospital outcomesPeriprocedural complicationsArtery diseaseBlood transfusion
2018
Stroke After Percutaneous Coronary Intervention in the Era of Transradial Intervention
Shoji S, Kohsaka S, Kumamaru H, Sawano M, Shiraishi Y, Ueda I, Noma S, Suzuki M, Numasawa Y, Hayashida K, Yuasa S, Miyata H, Fukuda K. Stroke After Percutaneous Coronary Intervention in the Era of Transradial Intervention. Circulation Cardiovascular Interventions 2018, 11: e006761. PMID: 30545258, DOI: 10.1161/circinterventions.118.006761.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionPeriprocedural strokeTransradial interventionTransfemoral interventionCoronary interventionAccess siteElective percutaneous coronary interventionPropensity score-matched analysisMultivariable logistic regression analysisOptimal access siteProspective multicenter databaseAcute kidney injuryAcute coronary syndromeChronic kidney diseaseLife-threatening complicationsPeripheral artery diseaseLogistic regression analysisCoronary syndromeHemorrhagic eventsKidney injuryPCI complicationsArtery diseaseMulticenter databaseStroke patientsKidney disease
2017
Relation of Baseline Hemoglobin Level to In-Hospital Outcomes in Patients Who Undergo Percutaneous Coronary Intervention (from a Japanese Multicenter Registry)
Numasawa Y, Ueda I, Sawano M, Kuno T, Kodaira M, Noma S, Suzuki M, Miyata H, Fukuda K, Kohsaka S. Relation of Baseline Hemoglobin Level to In-Hospital Outcomes in Patients Who Undergo Percutaneous Coronary Intervention (from a Japanese Multicenter Registry). The American Journal Of Cardiology 2017, 121: 695-702. PMID: 29361289, DOI: 10.1016/j.amjcard.2017.12.007.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionBaseline hemoglobinLower hemoglobin levelsHemoglobin levelsHospital mortalityCoronary interventionProcedural complicationsCases of PCIStable coronary artery diseaseHospital adverse outcomesJapanese multicenter registryLower baseline hemoglobinBaseline hemoglobin levelIn-Hospital OutcomesAcute coronary syndromeCoronary artery diseaseHigher hemoglobin levelsHospital complicationsPreprocedural hemoglobinCoronary syndromeHospital outcomesMulticenter registryRenal failureArtery diseaseDiabetes mellitusPrognostic Impact of Subsequent Acute Coronary Syndrome and Unplanned Revascularization on Long‐Term Mortality After an Index Percutaneous Coronary Intervention: A Report From a Japanese Multicenter Registry
Inohara T, Kohsaka S, Miyata H, Sawano M, Ueda I, Maekawa Y, Fukuda K, Jones PG, Cohen DJ, Zhao Z, Spertus JA, Smolderen KG. Prognostic Impact of Subsequent Acute Coronary Syndrome and Unplanned Revascularization on Long‐Term Mortality After an Index Percutaneous Coronary Intervention: A Report From a Japanese Multicenter Registry. Journal Of The American Heart Association 2017, 6: e006529. PMID: 29079567, PMCID: PMC5721753, DOI: 10.1161/jaha.117.006529.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngina, UnstableChi-Square DistributionFemaleHospitals, TeachingHumansIncidenceJapanLogistic ModelsMaleMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionPropensity ScoreProportional Hazards ModelsRegistriesRetreatmentRisk FactorsTime FactorsTreatment OutcomeConceptsSubsequent acute coronary syndromeAcute coronary syndromePercutaneous coronary interventionPropensity-matched cohortUnplanned coronary revascularizationIndex percutaneous coronary interventionComposite end pointUnplanned revascularizationCoronary revascularizationCoronary syndromeCoronary interventionUnstable anginaClinical trialsEnd pointJapanese multicenter registryLong-term mortalityAcute myocardial infarctionRisk of mortalityProportional hazards modelLong-term survivalJapanese teaching hospitalsCause mortalityMulticenter registryPCI patientsSubsequent survivalCharacteristics and in-hospital outcomes in young patients presenting with acute coronary syndrome treated by percutaneous coronary intervention
Hirota Y, Sawano M, Numasawa Y, Ueda I, Noma S, Suzuki M, Hayashida K, Yuasa S, Maekawa Y, Kohsaka S, Fukuda K. Characteristics and in-hospital outcomes in young patients presenting with acute coronary syndrome treated by percutaneous coronary intervention. Cardiovascular Intervention And Therapeutics 2017, 33: 154-162. PMID: 28585049, DOI: 10.1007/s12928-017-0471-z.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeCoronary artery diseaseMulti-vessel diseaseClassical risk factorsCardiogenic shockYounger patientsACS patientsHospital mortalityCoronary syndromeCulprit lesionRisk factorsFamily historyPremature coronary artery diseaseHigher body mass indexPercutaneous coronary intervention registryConsecutive ACS patientsYoung ACS patientsPrevalence of dyslipidemiaChronic kidney diseasePercutaneous coronary interventionCoronary Intervention RegistryBody mass indexCS presentationLonger life expectancyHospital outcomesOutcomes After Percutaneous Coronary Intervention of Acute Coronary Syndrome Complicated With Cardiopulmonary Arrest (from a Japanese Multicenter Registry)
Numasawa Y, Sawano M, Miyata H, Ueda I, Noma S, Suzuki M, Kuno T, Kodaira M, Maekawa Y, Fukuda K, Kohsaka S. Outcomes After Percutaneous Coronary Intervention of Acute Coronary Syndrome Complicated With Cardiopulmonary Arrest (from a Japanese Multicenter Registry). The American Journal Of Cardiology 2017, 119: 1173-1178. PMID: 28236456, DOI: 10.1016/j.amjcard.2017.01.007.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAge FactorsAgedBody Mass IndexFemaleHeart ArrestHospital MortalityHumansHypothermia, InducedJapanMaleMiddle AgedMultivariate AnalysisNo-Reflow PhenomenonPercutaneous Coronary InterventionProspective StudiesRegistriesShock, CardiogenicST Elevation Myocardial InfarctionConceptsAcute coronary syndromePercutaneous coronary interventionST-elevation myocardial infarctionCardiopulmonary arrestCardiogenic shockCoronary interventionInhospital mortalityMortality rateAcute Coronary Syndrome ComplicatedPresence of CSHours of admissionHigh mortality rateInhospital outcomesCoronary syndromeUnstable anginaIndependent predictorsShock statusMyocardial infarctionPatientsMultivariate analysisOlder ageInterventionOutcomesMortalityAge
2016
Degree of dyspnoea in patients with non‐ST‐elevation acute coronary syndrome: A report from Japanese multicenter registry
Shiraishi Y, Kohsaka S, Ueda I, Inohara T, Sawano M, Numasawa Y, Hayashida K, Maekawa Y, Momiyama Y, Fukuda K. Degree of dyspnoea in patients with non‐ST‐elevation acute coronary syndrome: A report from Japanese multicenter registry. International Journal Of Clinical Practice 2016, 70: 978-987. PMID: 28032431, DOI: 10.1111/ijcp.12905.Peer-Reviewed Original ResearchConceptsAcute heart failureAcute coronary syndromeElevation acute coronary syndromeDegree of dyspnoeaDyspnoea severityRenal eventsMajor cardiovascularHospital mortalityCoronary syndromeNon-ST elevation acute coronary syndromeJapanese multicenter registryMulticenter PCI registryNSTE-ACS patientsRenal event rateMild activityDyspnoeic symptomsNSTE-ACSHospital deathHospital outcomesMulticenter registryPCI registryMultivariate adjustmentConsecutive patientsHeart failureDyspnoea