A Randomized, Double‐blind, Sham‐controlled, Adaptive‐Design Pivotal Trial of Sensory Stimulation in Subjects with Alzheimer’s Disease
Boasso A, Houser C, Hajos M, Newberger J, Seshagiri C, Leach J, Konisky A, Galley A, Hempel E, Dickson S, Hendrix S, Malchano Z, Megerian J. A Randomized, Double‐blind, Sham‐controlled, Adaptive‐Design Pivotal Trial of Sensory Stimulation in Subjects with Alzheimer’s Disease. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.080670.Peer-Reviewed Original ResearchMini-Mental State ExamClinical Dementia Rating ScaleZarit Burden IndexPivotal trialsSensory stimulationAlzheimer's Disease Cooperative Study-ActivitiesConcurrent medication useOccipital cortical thicknessKey secondary outcomesProspective clinical trialsPrimary outcome measureSelf-administered therapyClinical laboratory assessmentsClinical efficacy assessmentBrain structural changesDaily living testDementia Rating ScaleSubgroup of subjectsMental State ExamAlzheimer's disease symptomsHOPE trialSecondary outcomesAdverse eventsMedication useADCS-ADL