2025
Bridging Care Gaps for Older Women Undergoing Percutaneous Coronary Intervention
Kalra K, Sampath R, Cigarroa N, Sutton N, Damluji A, Nanna M. Bridging Care Gaps for Older Women Undergoing Percutaneous Coronary Intervention. Interventional Cardiology Clinics 2025, 14: 69-79. PMID: 39537289, DOI: 10.1016/j.iccl.2024.08.006.Peer-Reviewed Original Research
2024
Invasive Versus Conservative Strategy in Older Adults ≥75 Years of Age With Non-ST-segment-Elevation Acute Coronary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Rout A, Moumneh M, Kalra K, Singh S, Garg A, Kunadian V, Biscaglia S, Alkhouli M, Rymer J, Batchelor W, Nanna M, Damluji A. Invasive Versus Conservative Strategy in Older Adults ≥75 Years of Age With Non-ST-segment-Elevation Acute Coronary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal Of The American Heart Association 2024, 13: e036151. PMID: 39494560, DOI: 10.1161/jaha.124.036151.Peer-Reviewed Original ResearchConceptsNon-ST segment elevation acute coronary syndromeAcute coronary syndromeComposite of deathBurden of geriatric conditionsRandomized controlled trialsCoronary syndromeMyocardial infarctionYears of ageInvasive strategyOlder adultsControlled trialsGeriatric conditionsOlder patientsCardiovascular deathOdds ratioMeta-analysis of randomized controlled trialsNon-ST segment elevationSecondary end pointsMeta-analysisFixed effects meta-analysisAll-cause deathEffects meta-analysisYounger patientsFollow-upDecreased riskPrognostic Value of Cardiovascular Biomarkers
Mangalesh S, Nanna M. Prognostic Value of Cardiovascular Biomarkers. JAMA 2024, 332: 1302-1303. PMID: 39292479, DOI: 10.1001/jama.2024.16522.Peer-Reviewed Original ResearchValidating the PREVENT Equations—A Contemporary Update to Cardiovascular Risk Assessment
Mangalesh S, Nanna M. Validating the PREVENT Equations—A Contemporary Update to Cardiovascular Risk Assessment. JAMA Network Open 2024, 7: e2438284. PMID: 39392636, DOI: 10.1001/jamanetworkopen.2024.38284.Peer-Reviewed Original ResearchComparative Analysis of PCI Strategies in Aortic Stenosis Patients Undergoing TAVI: A Systematic Review and Network Meta‐Analysis
Fallahtafti P, Soleimani H, Ebrahimi P, Ghaseminejad‐Raeini A, Karimi E, Shirinezhad A, Sabri M, Mehrani M, Taheri H, Siegel R, Shah N, Nanna M, Hakim D, Hosseini K. Comparative Analysis of PCI Strategies in Aortic Stenosis Patients Undergoing TAVI: A Systematic Review and Network Meta‐Analysis. Clinical Cardiology 2024, 47: e24324. PMID: 39054901, PMCID: PMC11272956, DOI: 10.1002/clc.24324.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationCoronary artery diseasePercutaneous coronary interventionIn-hospital mortalityNetwork meta-analysisMyocardial infarctionAortic stenosisAssociated with worse 30-day outcomeMeta-analysisIncreased risk of 1-year mortalityAssociated with higher 1-year mortalityRisk of 1-year mortalitySevere aortic stenosisFrequentist network meta-analysisRates of myocardial infarctionPercutaneous coronary intervention timeTime of revascularizationAortic valve implantationSevere ASNo significant differencePacemaker implantationPost-TAVIValve implantationPatient characteristicsArtery diseaseSearching for Meaning Refining Troponin Thresholds to Align Risks Between Spontaneous and Procedural Myocardial Infarction
Nanna M, Mangalesh S. Searching for Meaning Refining Troponin Thresholds to Align Risks Between Spontaneous and Procedural Myocardial Infarction. Journal Of The American College Of Cardiology 2024, 84: 478-481. PMID: 39048280, DOI: 10.1016/j.jacc.2024.05.042.Peer-Reviewed Original ResearchPercutaneous Coronary Revascularization Strategies After Myocardial Infarction A Systematic Review and Network Meta-Analysis
Reddy R, Howard J, Jamil Y, Madhavan M, Nanna M, Lansky A, Leon M, Ahmad Y. Percutaneous Coronary Revascularization Strategies After Myocardial Infarction A Systematic Review and Network Meta-Analysis. Journal Of The American College Of Cardiology 2024, 84: 276-294. PMID: 38986670, DOI: 10.1016/j.jacc.2024.04.051.Peer-Reviewed Original ResearchConceptsRelative riskCardiovascular mortalityMyocardial infarctionMultivessel coronary artery diseaseAll-cause mortalityAdverse cardiac eventsST-segment elevation myocardial infarctionComplete revascularizationCoronary artery diseaseBayesian network meta-analysesMortality reductionA systematic reviewNetwork meta-analysesElevation myocardial infarctionSystematic reviewMeta-analysesCardiac eventsArtery diseasePrimary outcomeNetwork meta-analysisRevascularization strategyMeta-analysisHead-to-head trialsCoronary revascularization strategyAcute kidney injuryRepresentation of Older Adults in the ACC/AHA/SCAI Guideline for Coronary Artery Revascularization
Jamil Y, Sibindi C, Park D, Frampton J, Damluji A, Nanna M. Representation of Older Adults in the ACC/AHA/SCAI Guideline for Coronary Artery Revascularization. JAMA Network Open 2024, 7: e2421547. PMID: 38995647, PMCID: PMC11245718, DOI: 10.1001/jamanetworkopen.2024.21547.Peer-Reviewed Original ResearchMachine learning prediction of one-year mortality after percutaneous coronary intervention in acute coronary syndrome patients
Hosseini K, Behnoush A, Khalaji A, Etemadi A, Soleimani H, Pasebani Y, Jenab Y, Masoudkabir F, Tajdini M, Mehrani M, Nanna M. Machine learning prediction of one-year mortality after percutaneous coronary intervention in acute coronary syndrome patients. International Journal Of Cardiology 2024, 409: 132191. PMID: 38777044, DOI: 10.1016/j.ijcard.2024.132191.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionLogistic regressionPost-PCI mortalityPrediction of one-year mortalityCoronary interventionPrediction of 1-year mortalityBody mass indexAcute coronary syndrome patientsOne-year mortalityIndividual-level assessmentsReceiver operating characteristic curveAcute coronary syndromeCoronary syndrome patientsTehran Heart CenterRates of comorbiditiesMass indexHigher ageSyndrome patientsCoronary syndromeHeart CenterFollow-upLipid profileU-shaped correlationPatientsCharacteristic curveCase Volumes and Outcomes Among Early-Career Interventional Cardiologists in the United States
Rymer J, Narcisse D, Chen A, Wojdyla D, Ashley S, Damluji A, Shah B, Nanna M, Swaminathan R, Gutierrez J, Uzendu A, Nelson A, Bethel G, Kearney K, Jones W, Rao S, Doll J. Case Volumes and Outcomes Among Early-Career Interventional Cardiologists in the United States. Journal Of The American College Of Cardiology 2024, 83: 1990-1998. PMID: 38749617, PMCID: PMC11173360, DOI: 10.1016/j.jacc.2024.03.395.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAnnual case volumeNational Cardiovascular Data Registry CathPCI RegistryCase volumeIncreased risk of mortalityBleeding riskRisk of mortalityST-segment elevation myocardial infarctionMedian annual case volumeEarly-careerCertificate databaseCathPCI RegistryInterventional cardiologistsMortality riskElevation myocardial infarctionAmerican BoardIncreased riskSystem databasePredicted riskBleeding outcomesAcute presentationTreated patientsMortality rateProcedural characteristicsCareer statusChronological vs Biological Age in Interventional Cardiology A Comprehensive Approach to Care for Older Adults: JACC Family Series
Damluji A, Nanna M, Rymer J, Kochar A, Lowenstern A, Baron S, Narins C, Alkhouli M. Chronological vs Biological Age in Interventional Cardiology A Comprehensive Approach to Care for Older Adults: JACC Family Series. JACC Cardiovascular Interventions 2024, 17: 961-978. PMID: 38597844, PMCID: PMC11097960, DOI: 10.1016/j.jcin.2024.01.284.Peer-Reviewed Original ResearchConceptsCardiovascular careImprove health outcomesOlder adult populationPatient-centered outcomesBiological ageAge-associated riskAging global populationAge-related riskFamily seriesComplex careHealth outcomesJACC State-of-the-Art ReviewOlder AdultsChronic illnessInfluence eligibilityProcedural adverse eventsStructural heart diseaseClinical focusCareOlder individualsInvasive careAdult populationInterventionCardiovascular diseaseOlder patientsShorter Dual Antiplatelet Therapy for Older Adults After Percutaneous Coronary Intervention
Park D, Hu J, Jamil Y, Kelsey M, Jones W, Frampton J, Kochar A, Aronow W, Damluji A, Nanna M. Shorter Dual Antiplatelet Therapy for Older Adults After Percutaneous Coronary Intervention. JAMA Network Open 2024, 7: e244000. PMID: 38546647, PMCID: PMC10979312, DOI: 10.1001/jamanetworkopen.2024.4000.Peer-Reviewed Original ResearchConceptsOlder adultsMonths of DAPTDuration of dual antiplatelet therapySystematic reviewRandomized clinical trialsPercutaneous coronary interventionMeta-analysisPreferred Reporting ItemsAssess data qualityRisk of bleedingDuration of DAPTDual antiplatelet therapyWeb of ScienceMain OutcomesReporting ItemsData extractionAbstracted dataSecondary outcomesRisk ratioAntiplatelet therapyPrimary outcomeCochrane LibraryCoronary interventionReference groupNetwork meta-analysisRole of Cognitive Frailty in Older Adults With Cardiovascular Disease
Ijaz N, Jamil Y, Brown C, Krishnaswami A, Orkaby A, Stimmel M, Gerstenblith G, Nanna M, Damluji A. Role of Cognitive Frailty in Older Adults With Cardiovascular Disease. Journal Of The American Heart Association 2024, 13: e033594. PMID: 38353229, PMCID: PMC11010094, DOI: 10.1161/jaha.123.033594.Peer-Reviewed Original ResearchConceptsCognitive frailtyCardiovascular diseaseDecreased cognitive reserveOlder adult populationCognitive impairmentEvidence of dementiaPresence of cognitive impairmentTargeted intervention studiesSedentary behaviorTobacco usePhysical frailtyOlder adultsGeriatric syndromesIntervention studiesCardiovascular cliniciansFrailtyAdult populationAssociated with poor outcomesCognitive reserveRisk factorsOlder patientsCliniciansPoor outcomeTherapeutic strategiesPathophysiological underpinningsIntravascular Imaging–Guided Versus Angiography‐Guided Percutaneous Coronary Intervention: A Systematic Review and Meta‐Analysis of Randomized Trials
Sreenivasan J, Reddy R, Jamil Y, Malik A, Chamie D, Howard J, Nanna M, Mintz G, Maehara A, Ali Z, Moses J, Chen S, Chieffo A, Colombo A, Leon M, Lansky A, Ahmad Y. Intravascular Imaging–Guided Versus Angiography‐Guided Percutaneous Coronary Intervention: A Systematic Review and Meta‐Analysis of Randomized Trials. Journal Of The American Heart Association 2024, 13: e031111. PMID: 38214263, PMCID: PMC10926835, DOI: 10.1161/jaha.123.031111.Peer-Reviewed Original ResearchConceptsAdverse cardiac eventsPercutaneous coronary interventionAngiography-guided percutaneous coronary interventionTarget vessel revascularizationTarget-lesion revascularizationCardiac eventsCardiac deathImaging-guided percutaneous coronary interventionWeighted mean follow-up durationMeta-analysisPrimary outcomeMean follow-up durationStent thrombosisMeta-analysis of randomized trialsStudy-level meta-analysisComplex lesion subsetsIntravascular imagingAll-cause deathRandom-effects meta-analysisStandard of careIntention-to-treat principleUpdates of clinical guidelinesMixed-effects meta-regressionComplex percutaneous coronary interventionIntravascular imaging-guided percutaneous coronary interventionChronic Coronary Disease in Older Adults
Ambrosini A, Fishman E, Damluji A, Nanna M. Chronic Coronary Disease in Older Adults. Medical Clinics Of North America 2024, 108: 581-594. PMID: 38548465, PMCID: PMC11040602, DOI: 10.1016/j.mcna.2023.12.004.Peer-Reviewed Original ResearchRisk Prediction for Atherosclerotic Cardiovascular Disease With and Without Race Stratification
Ghosh A, Venkatraman S, Nanna M, Safford M, Colantonio L, Brown T, Pinheiro L, Peterson E, Navar A, Sterling M, Soroka O, Nahid M, Banerjee S, Goyal P. Risk Prediction for Atherosclerotic Cardiovascular Disease With and Without Race Stratification. JAMA Cardiology 2024, 9: 55-62. PMID: 38055247, PMCID: PMC10701663, DOI: 10.1001/jamacardio.2023.4520.Peer-Reviewed Original ResearchConceptsLipoprotein cholesterol levelsAtherosclerotic cardiovascular diseaseCohort studyREGARDS cohortCholesterol levelsCardiovascular diseaseLow-density lipoprotein cholesterol levelsCoronary heart disease deathDensity lipoprotein cholesterol levelsRace-sex stratumHeart disease deathProspective cohort studyCohort risk equationsRisk predictionRace stratificationIncident ASCVDNonfatal strokeDisease deathsC-statisticMyocardial infarctionHigh riskRisk equationsSocial determinantsPercentage declineIncremental value
2023
Complex Percutaneous Coronary Intervention Outcomes in Older Adults
Hanna J, Wang S, Kochar A, Park D, Damluji A, Henry G, Ahmad Y, Curtis J, Nanna M. Complex Percutaneous Coronary Intervention Outcomes in Older Adults. Journal Of The American Heart Association 2023, 12: e029057. PMID: 37776222, PMCID: PMC10727245, DOI: 10.1161/jaha.122.029057.Peer-Reviewed Original ResearchConceptsNoncomplex percutaneous coronary interventionsComplex percutaneous coronary interventionStable ischemic heart diseasePercutaneous coronary interventionIschemic heart diseaseTarget lesion revascularizationEvent-free survivalHeart diseaseOlder adultsCause deathLesion revascularizationClinical characteristicsElective percutaneous coronary interventionPercutaneous coronary intervention outcomesWorse event-free survivalMedical therapy useCox regression modelLarge health systemNoncardiac comorbiditiesRevascularization riskCoronary interventionTherapy useClinical outcomesDisease featuresLower riskObesity and Undernutrition in Acute Myocardial Infarction
Mangalesh S, Nanna M. Obesity and Undernutrition in Acute Myocardial Infarction. The American Journal Of Cardiology 2023, 203: 529-530. PMID: 37563054, DOI: 10.1016/j.amjcard.2023.07.111.Peer-Reviewed Original ResearchComparison of intravascular ultrasound, optical coherence tomography, and conventional angiography‐guided percutaneous coronary interventions: A systematic review, network meta‐analysis, and meta‐regression
Park D, An S, Jolly N, Attanasio S, Yadav N, Gutierrez J, Nanna M, Rao S, Vij A. Comparison of intravascular ultrasound, optical coherence tomography, and conventional angiography‐guided percutaneous coronary interventions: A systematic review, network meta‐analysis, and meta‐regression. Catheterization And Cardiovascular Interventions 2023, 102: 440-450. PMID: 37483068, PMCID: PMC10908343, DOI: 10.1002/ccd.30784.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsPercutaneous coronary interventionOptical coherence tomographyCoronary angiographyIntravascular ultrasoundCoronary interventionCardiac deathClinical outcomesClinical efficacyConventional angiography-guided PCIAngiography-guided percutaneous coronary interventionCoherence tomographyUse of IVUSSuperiority of OCTAdverse cardiovascular eventsRandomized clinical trialsConventional coronary angiographyImaging modalitiesComparative clinical efficacyBest imaging modalityIntracoronary imaging modalityLesion revascularizationPCI guidanceCardiovascular eventsCause mortalityDelirium in older adults after percutaneous coronary intervention: Prevalence, risks, and clinical phenotypes
Park D, Jamil Y, Hu J, Lowenstern A, Frampton J, Abdullah A, Damluji A, Ahmad Y, Soufer R, Nanna M. Delirium in older adults after percutaneous coronary intervention: Prevalence, risks, and clinical phenotypes. Cardiovascular Revascularization Medicine 2023, 57: 60-67. PMID: 37414611, PMCID: PMC10730763, DOI: 10.1016/j.carrev.2023.06.010.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionHospital mortalityHigher oddsOlder adultsHospital deliriumCoronary interventionAdverse health-related outcomesInpatient percutaneous coronary interventionNon-home dischargePeri-procedural settingAcute kidney injuryImpact of deliriumPost-procedural complicationsNational Inpatient SampleHealth-related outcomesDelirium preventionHospital complicationsMore comorbiditiesGastrointestinal hemorrhageKidney injuryAdverse eventsSecondary outcomesBlood transfusionPrimary outcomeIntracranial hemorrhage