2024
Neuropeptide and serotonin co-transmission sets the activity pattern in the C. elegans egg-laying circuit
Butt A, Van Damme S, Santiago E, Olson A, Beets I, Koelle M. Neuropeptide and serotonin co-transmission sets the activity pattern in the C. elegans egg-laying circuit. Current Biology 2024, 34: 4704-4714.e5. PMID: 39395419, DOI: 10.1016/j.cub.2024.07.064.Peer-Reviewed Original ResearchHermaphrodite-specific neuronsEgg-laying circuitNlp-3Egg layingTiming of egg layingPromote egg layingCaenorhabditis elegansInactive phasePeptide signalsPersistent internal stateNeural circuit functionMolecular experimentsSerotonin receptorsSerotonin signalingSerotoninMuscle cellsNeurotransmitter serotoninMultiple signalsNeuropeptideNeuropeptide receptorsCo-transmissionEggsNeural circuitsLayingActive phase
2020
Cellular Expression and Functional Roles of All 26 Neurotransmitter GPCRs in the C. elegans Egg-Laying Circuit
Fernandez RW, Wei K, Wang EY, Mikalauskaite D, Olson A, Pepper J, Christie N, Kim S, Weissenborn S, Sarov M, Koelle MR. Cellular Expression and Functional Roles of All 26 Neurotransmitter GPCRs in the C. elegans Egg-Laying Circuit. Journal Of Neuroscience 2020, 40: 7475-7488. PMID: 32847964, PMCID: PMC7511189, DOI: 10.1523/jneurosci.1357-20.2020.Peer-Reviewed Original ResearchConceptsEgg-laying circuitNeurotransmitter GPCREgg-laying defectsModel organismsNeural circuitsExtrasynaptic signalsStandard laboratory conditionsSuch signalingGPCR expressionCell typesFunctional roleGPCRsNeurotransmitter signalsCellular expressionActivity of neuronsModel systemEpithelial cellsReceptor functionOrganismsNeurotransmitter receptorsLaboratory conditionsDistinct receptorsReceptor knockoutParkinson's diseaseCells
2016
Activity of the C. elegans egg-laying behavior circuit is controlled by competing activation and feedback inhibition
Collins KM, Bode A, Fernandez RW, Tanis JE, Brewer JC, Creamer MS, Koelle MR. Activity of the C. elegans egg-laying behavior circuit is controlled by competing activation and feedback inhibition. ELife 2016, 5: e21126. PMID: 27849154, PMCID: PMC5142809, DOI: 10.7554/elife.21126.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsChloride ChannelsCholineFeedback, PhysiologicalFemaleGene Expression RegulationLocomotionMotor NeuronsMuscle ContractionOptogeneticsOvipositionPeriodicityReceptors, Biogenic AmineSerotoninSexual Behavior, AnimalSignal TransductionTyramineConceptsPassage of eggsUnderlying neural circuitsUv1 neuroendocrine cellsCommand neuronsMuscle contractionNeural circuitsNeuroendocrine cellsRhythmic activityBehavior circuitsCircuit activityCentral pattern generatorCircuit functionBody bendsFeedback inhibitionSlow locomotionPattern generatorNeuronsActivityVulva