2006
Immunosurveillance and Immunoregulation by γδ T Cells
Girardi M. Immunosurveillance and Immunoregulation by γδ T Cells. Journal Of Investigative Dermatology 2006, 126: 25-31. PMID: 16417214, DOI: 10.1038/sj.jid.5700003.Peer-Reviewed Original ResearchConceptsGammadelta T cellsT cell receptorT cellsGammadelta T-cell receptorΓδ T cellsCellular stressHuman diseasesAlphabeta heterodimersTCR diversityCutaneous functionImmunoregulatory activitySmall populationMutant miceEpithelial surfaceCellsHeterodimersVast majorityDiversityImmunosurveillanceImmunoregulation
2005
Immunosurveillance by γδ T Cells: Focus on the Murine System
Girardi M, Hayday AC. Immunosurveillance by γδ T Cells: Focus on the Murine System. Chemical Immunology And Allergy 2005, 86: 136-150. PMID: 15976492, DOI: 10.1159/000086658.Peer-Reviewed Original ResearchConceptsT cell subsetsCell subsetsT cellsDistinct T cell subsetsSpecific T cell subsetsT cell responsesΓδ T cellsGammadelta T cellsPhysiologic immune responseLymphoid cell typesImmune surveillanceImmune responseMouse modelCell responsesClinical settingMurine systemCell typesDifferent genetic backgroundsGenetic backgroundAssociationCell associationCellsInflammationImmunosurveillanceSpecific tissues
2004
Cutaneous biology of gammadelta T cells.
Girardi M. Cutaneous biology of gammadelta T cells. Advances In Dermatology 2004, 20: 203-15. PMID: 15544201.Peer-Reviewed Original ResearchConceptsGammadelta T cellsT cellsInappropriate inflammatory responseNoninfectious skin diseasesMajor disease categoriesMost T cellsCutaneous inflammationLymph nodesCutaneous neoplasmsCutaneous tumorsCutaneous diseaseInflammatory responseReceptor subtypesSkin diseasesDisease categoriesEpidermal barrierCutaneous biologyInflammationLaboratory animalsNeoplastic transformationTCR variabilityDiseaseEpithelial tissuesCellsRecent studies
2003
γδ T Cells Provide an Early Source of Interferon γ in Tumor Immunity
Gao Y, Yang W, Pan M, Scully E, Girardi M, Augenlicht LH, Craft J, Yin Z. γδ T Cells Provide an Early Source of Interferon γ in Tumor Immunity. Journal Of Experimental Medicine 2003, 198: 433-442. PMID: 12900519, PMCID: PMC2194096, DOI: 10.1084/jem.20030584.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsImmunity, CellularInterferon-gammaInterleukin-12Lymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutNeoplasm TransplantationNeoplasms, ExperimentalReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsTransplantation ChimeraTumor Cells, CulturedConceptsGammadelta T cellsAlphabeta T cellsT cellsTumor immunityIFN-gammaHigh incidenceGammadelta T cell-deficient miceImpaired IFN-gamma productionT cell-deficient miceTumor developmentCell-deficient miceBone marrow chimerasΓδ T cellsIFN-gamma productionSite of tumorT cell repertoireWild-type miceChemical carcinogen methylcholanthreneMelanoma cell line B16B16 melanoma cellsTumor lysateCarcinogen methylcholanthreneTumor immunosurveillanceInterferon γSuch mice
2002
Resident Skin-specific γδ T Cells Provide Local, Nonredundant Regulation of Cutaneous Inflammation
Girardi M, Lewis J, Glusac E, Filler RB, Geng L, Hayday AC, Tigelaar RE. Resident Skin-specific γδ T Cells Provide Local, Nonredundant Regulation of Cutaneous Inflammation. Journal Of Experimental Medicine 2002, 195: 855-867. PMID: 11927630, PMCID: PMC2193718, DOI: 10.1084/jem.20012000.Peer-Reviewed Original ResearchConceptsT cell receptorEpidermal T cellsT cellsIrritant dermatitisGammadelta T-cell receptorT cell-mediated inflammationCell-mediated inflammationSystemic inflammatory reactionIrritant contact dermatitis reactionsΓδ T cellsGammadelta T cellsContact dermatitis reactionsCutaneous inflammationIEL subsetsChronic dermatitisFunctional impairmentInflammatory reactionDermatitis reactionsEpithelial interfaceCell subpopulationsCell receptorMiceMouse strainsDermatitisSingle autosomal recessive gene
2001
Regulation of Cutaneous Malignancy by γδ T Cells
Girardi M, Oppenheim D, Steele C, Lewis J, Glusac E, Filler R, Hobby P, Sutton B, Tigelaar R, Hayday A. Regulation of Cutaneous Malignancy by γδ T Cells. Science 2001, 294: 605-609. PMID: 11567106, DOI: 10.1126/science.1063916.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCarcinogensCell LineCytotoxicity, ImmunologicDimerizationEpidermisEpithelial CellsHistocompatibility Antigens Class IHumansImmunologic SurveillanceLigandsMembrane ProteinsMiceMice, Inbred C57BLMinor Histocompatibility AntigensMolecular Sequence DataNK Cell Lectin-Like Receptor Subfamily KProtein ConformationProtein FoldingReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaReceptors, ImmunologicReceptors, Natural Killer CellRecombinant Fusion ProteinsReverse Transcriptase Polymerase Chain ReactionSkin NeoplasmsT-Lymphocyte SubsetsConceptsT cellsGammadelta cellsLocal T cellsNatural killer cellsΓδ T cellsGammadelta T cellsCytolytic T cellsSkin carcinoma cellsNKG2D engagementMultiple regimensKiller cellsCutaneous malignanciesCutaneous carcinogenesisEpithelial malignanciesRAE-1Human MICAMalignancyCarcinoma cellsSkin cellsCellsNKG2DRegimensMiceEpitheliumCarcinogenesis